A cautionary perspective regarding the isolation and serial propagation of SARS-CoV-2 in Vero cells
Abstract An array of SARS-CoV-2 virus variants have been isolated, propagated and used in in vitro assays, in vivo animal studies and human clinical trials. Observations of working stocks of SARS-CoV-2 suggest that sequential propagation in Vero cells leads to critical changes in the region of the f...
Main Authors: | Simon G. P. Funnell, Babak Afrough, John James Baczenas, Neil Berry, Kevin R. Bewley, Rebecca Bradford, Clint Florence, Yann Le Duff, Mark Lewis, Ryan V. Moriarty, Shelby L. O. Connor, Karen L. Osman, Steven Pullan, Sujatha Rashid, Kevin S. Richards, Kimberly J. Stemple, Ivana Knezevic |
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Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2021-06-01
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Series: | npj Vaccines |
Online Access: | https://doi.org/10.1038/s41541-021-00346-z |
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