The function of novel small non‐coding RNAs (piRNAs, tRFs) and PIWI protein in colorectal cancer
Although great research has been done to clarify the pathogenesis of colorectal cancer (CRC), it is still the third common cancer worldwide. Pathogenesis of CRC as a heterogeneous disease is correlated with mutations and epigenetic alterations that result in the inactivation of tumor‐suppressive and...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-01-01
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| Series: | Cancer Treatment and Research Communications |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2468294222000338 |
| _version_ | 1818232262347456512 |
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| author | Mandana AmeliMojarad Melika AmeliMojarad Jian Wang |
| author_facet | Mandana AmeliMojarad Melika AmeliMojarad Jian Wang |
| author_sort | Mandana AmeliMojarad |
| collection | DOAJ |
| description | Although great research has been done to clarify the pathogenesis of colorectal cancer (CRC), it is still the third common cancer worldwide. Pathogenesis of CRC as a heterogeneous disease is correlated with mutations and epigenetic alterations that result in the inactivation of tumor‐suppressive and activation of an oncogene. Small non-coding RNAs (sncRNAs), emerging as a key player in regulating the genes and protein expression, with a length less than 200 nucleotide (nt). In this review, we aimed to focus on the role and the biogenesis of PIWI‐interacting RNA (piRNAs), and tRNA‐derived small RNA (tRFs) and PIWI proteins in the initiation, progression, and metastasis of CRC and their molecular mechanisms to understand their function in cancers and to provide better therapeutic strategies for CRC. |
| first_indexed | 2024-12-12T11:03:29Z |
| format | Article |
| id | doaj.art-d3e8ca76ff6f4309a86f2f148edb2bfa |
| institution | Directory Open Access Journal |
| issn | 2468-2942 |
| language | English |
| last_indexed | 2024-12-12T11:03:29Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cancer Treatment and Research Communications |
| spelling | doaj.art-d3e8ca76ff6f4309a86f2f148edb2bfa2022-12-22T00:26:28ZengElsevierCancer Treatment and Research Communications2468-29422022-01-0131100542The function of novel small non‐coding RNAs (piRNAs, tRFs) and PIWI protein in colorectal cancerMandana AmeliMojarad0Melika AmeliMojarad1Jian Wang2Department Genetic, Medical University of Tehran, Tehran, IranDepartment Genetic, Medical University of Tehran, Tehran, IranDepartment Genetic, Medical University of Tehran, Tehran, Iran; Department Molecular Medicine, University of Leeds, England, United KingdomAlthough great research has been done to clarify the pathogenesis of colorectal cancer (CRC), it is still the third common cancer worldwide. Pathogenesis of CRC as a heterogeneous disease is correlated with mutations and epigenetic alterations that result in the inactivation of tumor‐suppressive and activation of an oncogene. Small non-coding RNAs (sncRNAs), emerging as a key player in regulating the genes and protein expression, with a length less than 200 nucleotide (nt). In this review, we aimed to focus on the role and the biogenesis of PIWI‐interacting RNA (piRNAs), and tRNA‐derived small RNA (tRFs) and PIWI proteins in the initiation, progression, and metastasis of CRC and their molecular mechanisms to understand their function in cancers and to provide better therapeutic strategies for CRC.http://www.sciencedirect.com/science/article/pii/S2468294222000338piRNAtRFsPIWIColorectal cancer |
| spellingShingle | Mandana AmeliMojarad Melika AmeliMojarad Jian Wang The function of novel small non‐coding RNAs (piRNAs, tRFs) and PIWI protein in colorectal cancer Cancer Treatment and Research Communications piRNA tRFs PIWI Colorectal cancer |
| title | The function of novel small non‐coding RNAs (piRNAs, tRFs) and PIWI protein in colorectal cancer |
| title_full | The function of novel small non‐coding RNAs (piRNAs, tRFs) and PIWI protein in colorectal cancer |
| title_fullStr | The function of novel small non‐coding RNAs (piRNAs, tRFs) and PIWI protein in colorectal cancer |
| title_full_unstemmed | The function of novel small non‐coding RNAs (piRNAs, tRFs) and PIWI protein in colorectal cancer |
| title_short | The function of novel small non‐coding RNAs (piRNAs, tRFs) and PIWI protein in colorectal cancer |
| title_sort | function of novel small non coding rnas pirnas trfs and piwi protein in colorectal cancer |
| topic | piRNA tRFs PIWI Colorectal cancer |
| url | http://www.sciencedirect.com/science/article/pii/S2468294222000338 |
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