Ultrastructural changes in the rabbit chorioretinal complex following 577-nm laser photocoagulation
Background: There is no unanimously adopted approach to titrating laser parameters in subthreshold retinal laser photocoagulation without ophthalmoscopically visible fundus changes. Purpose: To investigate the ultrastructural changes in the rabbit chorioretinal complex following 577-nm convention...
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| Format: | Article |
| Language: | English |
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Ukrainian Society of Ophthalmologists
2017-08-01
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| Series: | Journal of Ophthalmology |
| Subjects: | |
| Online Access: | https://www.ozhurnal.com/en/archive/2017/4/10-fulltext |
| _version_ | 1797357458506645504 |
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| author | S.A. Fedchenko O.S. Zadorozhnyy N.I. Molchaniuk A.R. Korol |
| author_facet | S.A. Fedchenko O.S. Zadorozhnyy N.I. Molchaniuk A.R. Korol |
| author_sort | S.A. Fedchenko |
| collection | DOAJ |
| description | Background: There is no unanimously adopted approach to titrating laser parameters in subthreshold retinal laser photocoagulation without ophthalmoscopically visible fundus changes.
Purpose: To investigate the ultrastructural changes in the rabbit chorioretinal complex following 577-nm conventional, selective or micropulse retinal laser photocoagulation (RLPC).
Materials and Methods: Four rabbits (8 eyes) were involved in the experimental study and underwent the RLPC modes with the 577-nm system (Supra 577). Rabbits (n = 2/time point) were euthanized at postlaser days 1 and 14. Ultra-thin sections of their ocular tissue specimens were subjected to electron microscopy. In addition, 2 intact rabbits (4 eyes) were used as controls for comparison.
Results: Conventional RLPC resulted in damage to RPE cells, all photoreceptor compartments and choriocapillaries; selective RLPC resulted in damage to RPE cells and photoreceptor outer and inner segments; and micropulse RLPC with the power setting adjusted to 50% threshold resulted in damage mostly to apical aspects of RPE cells and photoreceptor outer segments.
Conclusion: 577-nm micropulse RLPC with the power setting adjusted to 50% threshold is a more photoreceptor- and choriocapillaris-sparing approach compared to conventional and selective RLPC, and can be used in clinical practice as a laser treatment approach with the least invasive effect on the chorioretinal complex. |
| first_indexed | 2024-03-08T14:45:25Z |
| format | Article |
| id | doaj.art-d3e93c31210d41769665763619feac93 |
| institution | Directory Open Access Journal |
| issn | 2412-8740 |
| language | English |
| last_indexed | 2024-03-08T14:45:25Z |
| publishDate | 2017-08-01 |
| publisher | Ukrainian Society of Ophthalmologists |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj.art-d3e93c31210d41769665763619feac932024-01-11T12:20:46ZengUkrainian Society of OphthalmologistsJournal of Ophthalmology2412-87402017-08-014555910.31288/oftalmolzh201745559Ultrastructural changes in the rabbit chorioretinal complex following 577-nm laser photocoagulationS.A. Fedchenko0O.S. Zadorozhnyy1N.I. Molchaniuk2A.R. Korol3Filatov Institute of Eye Diseases and Tissue TherapyFilatov Institute of Eye Diseases and Tissue TherapyFilatov Institute of Eye Diseases and Tissue TherapyFilatov Institute of Eye Diseases and Tissue TherapyBackground: There is no unanimously adopted approach to titrating laser parameters in subthreshold retinal laser photocoagulation without ophthalmoscopically visible fundus changes. Purpose: To investigate the ultrastructural changes in the rabbit chorioretinal complex following 577-nm conventional, selective or micropulse retinal laser photocoagulation (RLPC). Materials and Methods: Four rabbits (8 eyes) were involved in the experimental study and underwent the RLPC modes with the 577-nm system (Supra 577). Rabbits (n = 2/time point) were euthanized at postlaser days 1 and 14. Ultra-thin sections of their ocular tissue specimens were subjected to electron microscopy. In addition, 2 intact rabbits (4 eyes) were used as controls for comparison. Results: Conventional RLPC resulted in damage to RPE cells, all photoreceptor compartments and choriocapillaries; selective RLPC resulted in damage to RPE cells and photoreceptor outer and inner segments; and micropulse RLPC with the power setting adjusted to 50% threshold resulted in damage mostly to apical aspects of RPE cells and photoreceptor outer segments. Conclusion: 577-nm micropulse RLPC with the power setting adjusted to 50% threshold is a more photoreceptor- and choriocapillaris-sparing approach compared to conventional and selective RLPC, and can be used in clinical practice as a laser treatment approach with the least invasive effect on the chorioretinal complex. https://www.ozhurnal.com/en/archive/2017/4/10-fulltextchorioretinal complexlaser radiationultrastructural changesrabbit eye |
| spellingShingle | S.A. Fedchenko O.S. Zadorozhnyy N.I. Molchaniuk A.R. Korol Ultrastructural changes in the rabbit chorioretinal complex following 577-nm laser photocoagulation Journal of Ophthalmology chorioretinal complex laser radiation ultrastructural changes rabbit eye |
| title | Ultrastructural changes in the rabbit chorioretinal complex following 577-nm laser photocoagulation |
| title_full | Ultrastructural changes in the rabbit chorioretinal complex following 577-nm laser photocoagulation |
| title_fullStr | Ultrastructural changes in the rabbit chorioretinal complex following 577-nm laser photocoagulation |
| title_full_unstemmed | Ultrastructural changes in the rabbit chorioretinal complex following 577-nm laser photocoagulation |
| title_short | Ultrastructural changes in the rabbit chorioretinal complex following 577-nm laser photocoagulation |
| title_sort | ultrastructural changes in the rabbit chorioretinal complex following 577 nm laser photocoagulation |
| topic | chorioretinal complex laser radiation ultrastructural changes rabbit eye |
| url | https://www.ozhurnal.com/en/archive/2017/4/10-fulltext |
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