DASH Diet as a Proposal for Improvement in Cellular Immunity and Its Association with Metabolic Parameters in Persons with Overweight and Obesity
The development of obesity entails a chronic low-grade inflammatory state with increased pro-inflammatory cells, mainly in visceral adipose tissue (VAT). Additionally, dietary patterns have an influence on the regulation of chronic inflammation. Dietary Approaches to Stop Hypertension (DASH) include...
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MDPI AG
2021-10-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/13/10/3540 |
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| author | Carmen Paulina Rodríguez-López María Cristina González-Torres Carlos A. Aguilar-Salinas Oralia Nájera-Medina |
| author_facet | Carmen Paulina Rodríguez-López María Cristina González-Torres Carlos A. Aguilar-Salinas Oralia Nájera-Medina |
| author_sort | Carmen Paulina Rodríguez-López |
| collection | DOAJ |
| description | The development of obesity entails a chronic low-grade inflammatory state with increased pro-inflammatory cells, mainly in visceral adipose tissue (VAT). Additionally, dietary patterns have an influence on the regulation of chronic inflammation. Dietary Approaches to Stop Hypertension (DASH) include foods with an anti-inflammatory profile and that have positive impacts on body composition (BC), suggesting improvements in inflammatory processes. Objective: To analyze the impact of the DASH diet on cellular immunity, anthropometric, biochemical and BC parameters in patients with overweight and obesity, who could present metabolic syndrome. Methodology: Lymphocyte subpopulations, biochemical parameters, anthropometric parameters, and BC before and 8 weeks after intervention with the DASH diet in persons with overweight and obesity were measured. Results: Fifty-nine young adults participated in the study. After the intervention, no significant changes in biochemical parameters were observed, although a significant decrease in nearly all of the anthropometric and BC variables was found: waist circumference (<i>p</i> < 0.001), percentage and kilograms of fat (<i>p</i> < 0.001 and <i>p</i> < 0.025, respectively), VAT (<i>p</i> < 0.020), and weight (<i>p</i> < 0.001), as well as total lymphocytes and double-positive TCD4+ cells. A relation between changes in leukocyte subpopulations (monocytes, natural killer, helper and cytotoxic lymphocytes, and naive TCD4+ cells) and metabolic improvements (glucose, triglycerides, total cholesterol and LDL-c) was also found. Conclusions: The DASH diet promotes positive changes in lymphocyte subpopulations, anthropometric parameters and BC in persons with overweight and obesity. Future studies should elucidate the cellular and molecular mechanisms through which the DASH diet produces inmunometabolic improvement. |
| first_indexed | 2024-03-10T06:18:36Z |
| format | Article |
| id | doaj.art-d3e9ad1cb9374d60a91c9d404e108641 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T06:18:36Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-d3e9ad1cb9374d60a91c9d404e1086412023-11-22T19:30:10ZengMDPI AGNutrients2072-66432021-10-011310354010.3390/nu13103540DASH Diet as a Proposal for Improvement in Cellular Immunity and Its Association with Metabolic Parameters in Persons with Overweight and ObesityCarmen Paulina Rodríguez-López0María Cristina González-Torres1Carlos A. Aguilar-Salinas2Oralia Nájera-Medina3Departamento de Atención a la Salud, CBS, Universidad Metropolitano México-Xochimilco (UAM-Xochimilco), Mexico City 04960, MexicoDepartamento de Ciencias de la Salud, CBS, Universidad Autónoma Metropolitano-Iztapalapa (UAM-Iztapalapa), Mexico City 09340, MexicoDepartamento de Endocrinología y Metabolismo, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán (INCMNSZ), Mexico City 14080, MexicoDepartamento de Atención a la Salud, CBS, Universidad Metropolitano México-Xochimilco (UAM-Xochimilco), Mexico City 04960, MexicoThe development of obesity entails a chronic low-grade inflammatory state with increased pro-inflammatory cells, mainly in visceral adipose tissue (VAT). Additionally, dietary patterns have an influence on the regulation of chronic inflammation. Dietary Approaches to Stop Hypertension (DASH) include foods with an anti-inflammatory profile and that have positive impacts on body composition (BC), suggesting improvements in inflammatory processes. Objective: To analyze the impact of the DASH diet on cellular immunity, anthropometric, biochemical and BC parameters in patients with overweight and obesity, who could present metabolic syndrome. Methodology: Lymphocyte subpopulations, biochemical parameters, anthropometric parameters, and BC before and 8 weeks after intervention with the DASH diet in persons with overweight and obesity were measured. Results: Fifty-nine young adults participated in the study. After the intervention, no significant changes in biochemical parameters were observed, although a significant decrease in nearly all of the anthropometric and BC variables was found: waist circumference (<i>p</i> < 0.001), percentage and kilograms of fat (<i>p</i> < 0.001 and <i>p</i> < 0.025, respectively), VAT (<i>p</i> < 0.020), and weight (<i>p</i> < 0.001), as well as total lymphocytes and double-positive TCD4+ cells. A relation between changes in leukocyte subpopulations (monocytes, natural killer, helper and cytotoxic lymphocytes, and naive TCD4+ cells) and metabolic improvements (glucose, triglycerides, total cholesterol and LDL-c) was also found. Conclusions: The DASH diet promotes positive changes in lymphocyte subpopulations, anthropometric parameters and BC in persons with overweight and obesity. Future studies should elucidate the cellular and molecular mechanisms through which the DASH diet produces inmunometabolic improvement.https://www.mdpi.com/2072-6643/13/10/3540obesitychronic inflammationdietary pattern |
| spellingShingle | Carmen Paulina Rodríguez-López María Cristina González-Torres Carlos A. Aguilar-Salinas Oralia Nájera-Medina DASH Diet as a Proposal for Improvement in Cellular Immunity and Its Association with Metabolic Parameters in Persons with Overweight and Obesity Nutrients obesity chronic inflammation dietary pattern |
| title | DASH Diet as a Proposal for Improvement in Cellular Immunity and Its Association with Metabolic Parameters in Persons with Overweight and Obesity |
| title_full | DASH Diet as a Proposal for Improvement in Cellular Immunity and Its Association with Metabolic Parameters in Persons with Overweight and Obesity |
| title_fullStr | DASH Diet as a Proposal for Improvement in Cellular Immunity and Its Association with Metabolic Parameters in Persons with Overweight and Obesity |
| title_full_unstemmed | DASH Diet as a Proposal for Improvement in Cellular Immunity and Its Association with Metabolic Parameters in Persons with Overweight and Obesity |
| title_short | DASH Diet as a Proposal for Improvement in Cellular Immunity and Its Association with Metabolic Parameters in Persons with Overweight and Obesity |
| title_sort | dash diet as a proposal for improvement in cellular immunity and its association with metabolic parameters in persons with overweight and obesity |
| topic | obesity chronic inflammation dietary pattern |
| url | https://www.mdpi.com/2072-6643/13/10/3540 |
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