In vitro evaluation of the controlled release of antibiotics from liposomes
Results of this study have shown significantly prolonged release of selected antibiotic from liposome dispersion as compared to free antibiotic solution of the same initial concentration. Two models of non-steady one-dimensional diffusion were successfully applied to the experimental data and the an...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Association of Chemical Engineers of Serbia
2003-01-01
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| Series: | Hemijska Industrija |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0367-598X/2003/0367-598X0312589B.pdf |
| _version_ | 1818327508373733376 |
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| author | Boltić Zorana Petkovska Menka T. Obradović Bojana M. Nedović Viktor A. Bugarski Branko M. |
| author_facet | Boltić Zorana Petkovska Menka T. Obradović Bojana M. Nedović Viktor A. Bugarski Branko M. |
| author_sort | Boltić Zorana |
| collection | DOAJ |
| description | Results of this study have shown significantly prolonged release of selected antibiotic from liposome dispersion as compared to free antibiotic solution of the same initial concentration. Two models of non-steady one-dimensional diffusion were successfully applied to the experimental data and the antibiotic diffusion coefficients were estimated. In addition, the mass transfer resistance of the membrane was shown to be insignificant confirming the suitability of the applied experimental system. Since liposomes are known as systems with slower drug release, then, when it comes to their incorporation in the final form of a preparation for further experiments in vivo, the system of choice would be liposomes with an encapsulated antibiotic drug. The established experimental system could be extended to other liposome formulations with respect to the release rate of the active components. |
| first_indexed | 2024-12-13T12:17:23Z |
| format | Article |
| id | doaj.art-d3ebeb5c60ef41df81a0f977f249bd8f |
| institution | Directory Open Access Journal |
| issn | 0367-598X |
| language | English |
| last_indexed | 2024-12-13T12:17:23Z |
| publishDate | 2003-01-01 |
| publisher | Association of Chemical Engineers of Serbia |
| record_format | Article |
| series | Hemijska Industrija |
| spelling | doaj.art-d3ebeb5c60ef41df81a0f977f249bd8f2022-12-21T23:46:42ZengAssociation of Chemical Engineers of SerbiaHemijska Industrija0367-598X2003-01-01571258959510.2298/HEMIND0312589BIn vitro evaluation of the controlled release of antibiotics from liposomesBoltić ZoranaPetkovska Menka T.Obradović Bojana M.Nedović Viktor A.Bugarski Branko M.Results of this study have shown significantly prolonged release of selected antibiotic from liposome dispersion as compared to free antibiotic solution of the same initial concentration. Two models of non-steady one-dimensional diffusion were successfully applied to the experimental data and the antibiotic diffusion coefficients were estimated. In addition, the mass transfer resistance of the membrane was shown to be insignificant confirming the suitability of the applied experimental system. Since liposomes are known as systems with slower drug release, then, when it comes to their incorporation in the final form of a preparation for further experiments in vivo, the system of choice would be liposomes with an encapsulated antibiotic drug. The established experimental system could be extended to other liposome formulations with respect to the release rate of the active components.http://www.doiserbia.nb.rs/img/doi/0367-598X/2003/0367-598X0312589B.pdfMembrane moduleControlled releaseLiposomesDiffusionModeling |
| spellingShingle | Boltić Zorana Petkovska Menka T. Obradović Bojana M. Nedović Viktor A. Bugarski Branko M. In vitro evaluation of the controlled release of antibiotics from liposomes Hemijska Industrija Membrane module Controlled release Liposomes Diffusion Modeling |
| title | In vitro evaluation of the controlled release of antibiotics from liposomes |
| title_full | In vitro evaluation of the controlled release of antibiotics from liposomes |
| title_fullStr | In vitro evaluation of the controlled release of antibiotics from liposomes |
| title_full_unstemmed | In vitro evaluation of the controlled release of antibiotics from liposomes |
| title_short | In vitro evaluation of the controlled release of antibiotics from liposomes |
| title_sort | in vitro evaluation of the controlled release of antibiotics from liposomes |
| topic | Membrane module Controlled release Liposomes Diffusion Modeling |
| url | http://www.doiserbia.nb.rs/img/doi/0367-598X/2003/0367-598X0312589B.pdf |
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