Association between serum lipid profile and liver fibrosis in patients infected with Schistosoma japonicum
Abstract Background Liver fibrosis is thought to have a close relationship with lipid profile. The possible association between lipids and liver fibrosis of different etiologies has been widely explored. However, the association between lipids and liver fibrosis in patients infected with Schistosoma...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-07-01
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| Series: | Parasites & Vectors |
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| Online Access: | https://doi.org/10.1186/s13071-022-05359-8 |
| _version_ | 1828430714114146304 |
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| author | Yang Liu PengPeng Zhang JunHui Li Hao Li Chen Zhou Yu Zhang YingZi Ming |
| author_facet | Yang Liu PengPeng Zhang JunHui Li Hao Li Chen Zhou Yu Zhang YingZi Ming |
| author_sort | Yang Liu |
| collection | DOAJ |
| description | Abstract Background Liver fibrosis is thought to have a close relationship with lipid profile. The possible association between lipids and liver fibrosis of different etiologies has been widely explored. However, the association between lipids and liver fibrosis in patients infected with Schistosoma japonicum remains unclear. In the present study we undertook a preliminary exploration of the association between lipid profile and liver fibrosis, and developed a new predictive index for liver fibrosis in S. japonicum-infected patients. Methods A total of 1503 patients diagnosed with S. japonicum at Xiangyue Hospital, China were enrolled in this retrospective study. The patients were divided into two groups, i.e., those with and those without liver fibrosis, by two experienced schistosomiasis specialists, according to the results of liver ultrasound examination. Demographic, clinical, and laboratory data were collected. Multivariable logistic models were used to estimate the independent associations between lipid profile and liver fibrosis. Receiver operating characteristic (ROC) curves were used to assess the discriminative ability of the new index in predicting liver fibrosis in patients with schistosomiasis. Results Logistic regression analysis showed that high-density lipoprotein (HDL) [adjusted odds ratio (aOR), 95% confidence interval (CI) 7.334, 5.051–10.649; P < 0.001], low-density lipoprotein (LDL) (aOR, 95% CI 0.434, 0.370–0.509; P < 0.001), hemoglobin (HB) (aOR, 95% CI 0.979, 0.971–0.987; P < 0.001) and platelets (PLT) (aOR, 95% CI 0.996, 0.994–0.999; P < 0.001) were independently associated with liver fibrosis in patients with schistosomiasis. ROC analysis indicated that the combination of HDL, LDL and HB levels [(HDL × 100)/(LDL × HB)] had a higher area under the ROC curve (AUC = 0.773), and thus may better predict liver fibrosis than the aspartate transaminase-to-platelet ratio index (AUC = 0.608) and fibrosis index based on four factors (AUC = 0.624). Conclusions To the best of our knowledge, this is the first study to report that HDL, LDL, HB and PLT levels are independently associated with liver fibrosis in patients with schistosomiasis. (HDL × 100)/(LDL × HB) outperformed the aspartate transaminase-to-platelet ratio index and fibrosis index based on four factors in terms of ROC, and thus could be a new predictive index for liver fibrosis. These findings may help clinicians to more easily and effectively diagnose liver fibrosis in patients with schistosomiasis. Graphical abstract |
| first_indexed | 2024-12-10T17:52:38Z |
| format | Article |
| id | doaj.art-d3ec32d695384a7c87a3681b7d5aecbf |
| institution | Directory Open Access Journal |
| issn | 1756-3305 |
| language | English |
| last_indexed | 2024-12-10T17:52:38Z |
| publishDate | 2022-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Parasites & Vectors |
| spelling | doaj.art-d3ec32d695384a7c87a3681b7d5aecbf2022-12-22T01:39:01ZengBMCParasites & Vectors1756-33052022-07-011511810.1186/s13071-022-05359-8Association between serum lipid profile and liver fibrosis in patients infected with Schistosoma japonicumYang Liu0PengPeng Zhang1JunHui Li2Hao Li3Chen Zhou4Yu Zhang5YingZi Ming6Transplantation Center, Third Xiangya Hospital, Central South UniversityTransplantation Center, Third Xiangya Hospital, Central South UniversityTransplantation Center, Third Xiangya Hospital, Central South UniversityTransplantation Center, Third Xiangya Hospital, Central South UniversityTransplantation Center, Third Xiangya Hospital, Central South UniversityTransplantation Center, Third Xiangya Hospital, Central South UniversityTransplantation Center, Third Xiangya Hospital, Central South UniversityAbstract Background Liver fibrosis is thought to have a close relationship with lipid profile. The possible association between lipids and liver fibrosis of different etiologies has been widely explored. However, the association between lipids and liver fibrosis in patients infected with Schistosoma japonicum remains unclear. In the present study we undertook a preliminary exploration of the association between lipid profile and liver fibrosis, and developed a new predictive index for liver fibrosis in S. japonicum-infected patients. Methods A total of 1503 patients diagnosed with S. japonicum at Xiangyue Hospital, China were enrolled in this retrospective study. The patients were divided into two groups, i.e., those with and those without liver fibrosis, by two experienced schistosomiasis specialists, according to the results of liver ultrasound examination. Demographic, clinical, and laboratory data were collected. Multivariable logistic models were used to estimate the independent associations between lipid profile and liver fibrosis. Receiver operating characteristic (ROC) curves were used to assess the discriminative ability of the new index in predicting liver fibrosis in patients with schistosomiasis. Results Logistic regression analysis showed that high-density lipoprotein (HDL) [adjusted odds ratio (aOR), 95% confidence interval (CI) 7.334, 5.051–10.649; P < 0.001], low-density lipoprotein (LDL) (aOR, 95% CI 0.434, 0.370–0.509; P < 0.001), hemoglobin (HB) (aOR, 95% CI 0.979, 0.971–0.987; P < 0.001) and platelets (PLT) (aOR, 95% CI 0.996, 0.994–0.999; P < 0.001) were independently associated with liver fibrosis in patients with schistosomiasis. ROC analysis indicated that the combination of HDL, LDL and HB levels [(HDL × 100)/(LDL × HB)] had a higher area under the ROC curve (AUC = 0.773), and thus may better predict liver fibrosis than the aspartate transaminase-to-platelet ratio index (AUC = 0.608) and fibrosis index based on four factors (AUC = 0.624). Conclusions To the best of our knowledge, this is the first study to report that HDL, LDL, HB and PLT levels are independently associated with liver fibrosis in patients with schistosomiasis. (HDL × 100)/(LDL × HB) outperformed the aspartate transaminase-to-platelet ratio index and fibrosis index based on four factors in terms of ROC, and thus could be a new predictive index for liver fibrosis. These findings may help clinicians to more easily and effectively diagnose liver fibrosis in patients with schistosomiasis. Graphical abstracthttps://doi.org/10.1186/s13071-022-05359-8LipidLiver fibrosisSchistosomiasisHigh-density lipoproteinLow-density lipoproteinHemoglobin |
| spellingShingle | Yang Liu PengPeng Zhang JunHui Li Hao Li Chen Zhou Yu Zhang YingZi Ming Association between serum lipid profile and liver fibrosis in patients infected with Schistosoma japonicum Parasites & Vectors Lipid Liver fibrosis Schistosomiasis High-density lipoprotein Low-density lipoprotein Hemoglobin |
| title | Association between serum lipid profile and liver fibrosis in patients infected with Schistosoma japonicum |
| title_full | Association between serum lipid profile and liver fibrosis in patients infected with Schistosoma japonicum |
| title_fullStr | Association between serum lipid profile and liver fibrosis in patients infected with Schistosoma japonicum |
| title_full_unstemmed | Association between serum lipid profile and liver fibrosis in patients infected with Schistosoma japonicum |
| title_short | Association between serum lipid profile and liver fibrosis in patients infected with Schistosoma japonicum |
| title_sort | association between serum lipid profile and liver fibrosis in patients infected with schistosoma japonicum |
| topic | Lipid Liver fibrosis Schistosomiasis High-density lipoprotein Low-density lipoprotein Hemoglobin |
| url | https://doi.org/10.1186/s13071-022-05359-8 |
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