New insights into the key role of HIF-1α in IL-10-producing B cells
Hypoxia-inducible factors (HIFs) are essential transcription factors for the cellular response to hypoxia. Expression and stabilization of HIFs can be triggered by hypoxia or by other factors under pathological stress such as inflammation and infection. Indeed, regulatory function of HIFs has been i...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Shared Science Publishers OG
2018-03-01
|
| Series: | Cell Stress |
| Subjects: | |
| Online Access: | http://www.cell-stress.com/researcharticles/new-insights-into-the-key-role-of-hif-1%CE%B1-in-il-10-producing-b-cells/ |
| _version_ | 1819267806649122816 |
|---|---|
| author | Xianyi Meng Aline Bozec |
| author_facet | Xianyi Meng Aline Bozec |
| author_sort | Xianyi Meng |
| collection | DOAJ |
| description | Hypoxia-inducible factors (HIFs) are essential transcription factors for the cellular response to hypoxia. Expression and stabilization of HIFs can be triggered by hypoxia or by other factors under pathological stress such as inflammation and infection. Indeed, regulatory function of HIFs has been implicated in a variety of different immune cells like macrophages and T cells. In our recent study, we delineated HIF-1α and HIF-2α roles in B cells (Nat Commun, 9:251). We demonstrated that lack of HIF-1α in B cells leads to impaired IL-10-producing CD1dhiCD5+ B cells expansion by modulating their glycolytic metabolism. We identified HIF-1α as a critical transcriptional factor involved in IL-10 production by B cells, thereby influencing the course of autoimmune diseases. |
| first_indexed | 2024-12-23T21:23:01Z |
| format | Article |
| id | doaj.art-d3ec368e793c413f93ca30b1649cdc71 |
| institution | Directory Open Access Journal |
| issn | 2523-0204 |
| language | English |
| last_indexed | 2024-12-23T21:23:01Z |
| publishDate | 2018-03-01 |
| publisher | Shared Science Publishers OG |
| record_format | Article |
| series | Cell Stress |
| spelling | doaj.art-d3ec368e793c413f93ca30b1649cdc712022-12-21T17:30:41ZengShared Science Publishers OGCell Stress2523-02042018-03-0124949510.15698/cst2018.04.133New insights into the key role of HIF-1α in IL-10-producing B cellsXianyi Meng0Aline Bozec1Department of Internal Medicine 3, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen, Erlangen, 91054, Germany.Department of Internal Medicine 3, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen, Erlangen, 91054, Germany.Hypoxia-inducible factors (HIFs) are essential transcription factors for the cellular response to hypoxia. Expression and stabilization of HIFs can be triggered by hypoxia or by other factors under pathological stress such as inflammation and infection. Indeed, regulatory function of HIFs has been implicated in a variety of different immune cells like macrophages and T cells. In our recent study, we delineated HIF-1α and HIF-2α roles in B cells (Nat Commun, 9:251). We demonstrated that lack of HIF-1α in B cells leads to impaired IL-10-producing CD1dhiCD5+ B cells expansion by modulating their glycolytic metabolism. We identified HIF-1α as a critical transcriptional factor involved in IL-10 production by B cells, thereby influencing the course of autoimmune diseases.http://www.cell-stress.com/researcharticles/new-insights-into-the-key-role-of-hif-1%CE%B1-in-il-10-producing-b-cells/HIF-1αIL-10B cellsglycolysismetabolismautoimmune disease |
| spellingShingle | Xianyi Meng Aline Bozec New insights into the key role of HIF-1α in IL-10-producing B cells Cell Stress HIF-1α IL-10 B cells glycolysis metabolism autoimmune disease |
| title | New insights into the key role of HIF-1α in IL-10-producing B cells |
| title_full | New insights into the key role of HIF-1α in IL-10-producing B cells |
| title_fullStr | New insights into the key role of HIF-1α in IL-10-producing B cells |
| title_full_unstemmed | New insights into the key role of HIF-1α in IL-10-producing B cells |
| title_short | New insights into the key role of HIF-1α in IL-10-producing B cells |
| title_sort | new insights into the key role of hif 1α in il 10 producing b cells |
| topic | HIF-1α IL-10 B cells glycolysis metabolism autoimmune disease |
| url | http://www.cell-stress.com/researcharticles/new-insights-into-the-key-role-of-hif-1%CE%B1-in-il-10-producing-b-cells/ |
| work_keys_str_mv | AT xianyimeng newinsightsintothekeyroleofhif1ainil10producingbcells AT alinebozec newinsightsintothekeyroleofhif1ainil10producingbcells |