Spatial accuracy of computed tomography perfusion to estimate the follow-up infarct on diffusion-weighted imaging after successful mechanical thrombectomy
Abstract Background Volumetric accuracy of using computed tomography perfusion (CTP) to estimate the post-treatment infarct in stroke patients with successful recanalization after mechanical thrombectomy (MT) has been studied a lot, however the spatial accuracy and its influence factors has not been...
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| Format: | Article |
| Language: | English |
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BMC
2023-01-01
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| Series: | BMC Neurology |
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| Online Access: | https://doi.org/10.1186/s12883-023-03075-z |
| _version_ | 1828056817698078720 |
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| author | Xiao-Quan Xu Gao Ma Guang-Chen Shen Shan-Shan Lu Hai-Bin Shi Ya-Xi Zhang Yu Zhang Fei-Yun Wu Sheng Liu |
| author_facet | Xiao-Quan Xu Gao Ma Guang-Chen Shen Shan-Shan Lu Hai-Bin Shi Ya-Xi Zhang Yu Zhang Fei-Yun Wu Sheng Liu |
| author_sort | Xiao-Quan Xu |
| collection | DOAJ |
| description | Abstract Background Volumetric accuracy of using computed tomography perfusion (CTP) to estimate the post-treatment infarct in stroke patients with successful recanalization after mechanical thrombectomy (MT) has been studied a lot, however the spatial accuracy and its influence factors has not been fully investigated. Methods This retrospective study reviewed the data from consecutive anterior large vessel occlusion (LVO) patients who had baseline CTP, successful recanalization after MT, and post-treatment diffusion-weighed imaging (DWI). Ischemic core on baseline CTP was estimated using relative cerebral blood flood (CBF) of < 30%. The infarct area was outlined manually on post-treatment DWI, and registered to CTP. Spatial agreement was assessed using the Dice similarity coefficient (DSC) and average Hausdorff distance. According to the median DSC, the study population was dichotomized into high and low Dice groups. Univariable and multivariable regression analyses were used to determine the factors independently associated with the spatial agreement. Results In 72 included patients, the median DSC was 0.26, and the median average Hausdorff distance was 1.77 mm. High Dice group showed significantly higher median ischemic core volume on baseline CTP (33.90 mL vs 3.40 mL, P < 0.001), lower proportion of moderate or severe leukoaraiosis [27.78% vs 52.78%, P = 0.031], and higher median infarct volume on follow-up DWI (51.17 mL vs 9.42 mL, P < 0.001) than low Dice group. Ischemic core volume on baseline CTP was found to be independently associated with the spatial agreement (OR, 1.092; P < 0.001). Conclusions CTP could help to spatially locate the post-treatment infarct in anterior LVO patients who achieving successful recanalization after MT. Ischemic core volume on baseline CTP was independently associated with the spatial agreement. |
| first_indexed | 2024-04-10T21:02:32Z |
| format | Article |
| id | doaj.art-d3f031e564374b43b038578e29c3a633 |
| institution | Directory Open Access Journal |
| issn | 1471-2377 |
| language | English |
| last_indexed | 2024-04-10T21:02:32Z |
| publishDate | 2023-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Neurology |
| spelling | doaj.art-d3f031e564374b43b038578e29c3a6332023-01-22T12:17:33ZengBMCBMC Neurology1471-23772023-01-012311810.1186/s12883-023-03075-zSpatial accuracy of computed tomography perfusion to estimate the follow-up infarct on diffusion-weighted imaging after successful mechanical thrombectomyXiao-Quan Xu0Gao Ma1Guang-Chen Shen2Shan-Shan Lu3Hai-Bin Shi4Ya-Xi Zhang5Yu Zhang6Fei-Yun Wu7Sheng Liu8Department of Radiology, The First Affiliated Hospital of Nanjing Medical UniversityDepartment of Radiology, The First Affiliated Hospital of Nanjing Medical UniversityDepartment of Radiology, The First Affiliated Hospital of Nanjing Medical UniversityDepartment of Radiology, The First Affiliated Hospital of Nanjing Medical UniversityDepartment of Interventional Radiology, The First Affiliated Hospital of Nanjing Medical UniversityShukun Network Technology Co., LtdShukun Network Technology Co., LtdDepartment of Radiology, The First Affiliated Hospital of Nanjing Medical UniversityDepartment of Interventional Radiology, The First Affiliated Hospital of Nanjing Medical UniversityAbstract Background Volumetric accuracy of using computed tomography perfusion (CTP) to estimate the post-treatment infarct in stroke patients with successful recanalization after mechanical thrombectomy (MT) has been studied a lot, however the spatial accuracy and its influence factors has not been fully investigated. Methods This retrospective study reviewed the data from consecutive anterior large vessel occlusion (LVO) patients who had baseline CTP, successful recanalization after MT, and post-treatment diffusion-weighed imaging (DWI). Ischemic core on baseline CTP was estimated using relative cerebral blood flood (CBF) of < 30%. The infarct area was outlined manually on post-treatment DWI, and registered to CTP. Spatial agreement was assessed using the Dice similarity coefficient (DSC) and average Hausdorff distance. According to the median DSC, the study population was dichotomized into high and low Dice groups. Univariable and multivariable regression analyses were used to determine the factors independently associated with the spatial agreement. Results In 72 included patients, the median DSC was 0.26, and the median average Hausdorff distance was 1.77 mm. High Dice group showed significantly higher median ischemic core volume on baseline CTP (33.90 mL vs 3.40 mL, P < 0.001), lower proportion of moderate or severe leukoaraiosis [27.78% vs 52.78%, P = 0.031], and higher median infarct volume on follow-up DWI (51.17 mL vs 9.42 mL, P < 0.001) than low Dice group. Ischemic core volume on baseline CTP was found to be independently associated with the spatial agreement (OR, 1.092; P < 0.001). Conclusions CTP could help to spatially locate the post-treatment infarct in anterior LVO patients who achieving successful recanalization after MT. Ischemic core volume on baseline CTP was independently associated with the spatial agreement.https://doi.org/10.1186/s12883-023-03075-zStrokeThrombectomyComputed tomography perfusionInfarctLocation |
| spellingShingle | Xiao-Quan Xu Gao Ma Guang-Chen Shen Shan-Shan Lu Hai-Bin Shi Ya-Xi Zhang Yu Zhang Fei-Yun Wu Sheng Liu Spatial accuracy of computed tomography perfusion to estimate the follow-up infarct on diffusion-weighted imaging after successful mechanical thrombectomy BMC Neurology Stroke Thrombectomy Computed tomography perfusion Infarct Location |
| title | Spatial accuracy of computed tomography perfusion to estimate the follow-up infarct on diffusion-weighted imaging after successful mechanical thrombectomy |
| title_full | Spatial accuracy of computed tomography perfusion to estimate the follow-up infarct on diffusion-weighted imaging after successful mechanical thrombectomy |
| title_fullStr | Spatial accuracy of computed tomography perfusion to estimate the follow-up infarct on diffusion-weighted imaging after successful mechanical thrombectomy |
| title_full_unstemmed | Spatial accuracy of computed tomography perfusion to estimate the follow-up infarct on diffusion-weighted imaging after successful mechanical thrombectomy |
| title_short | Spatial accuracy of computed tomography perfusion to estimate the follow-up infarct on diffusion-weighted imaging after successful mechanical thrombectomy |
| title_sort | spatial accuracy of computed tomography perfusion to estimate the follow up infarct on diffusion weighted imaging after successful mechanical thrombectomy |
| topic | Stroke Thrombectomy Computed tomography perfusion Infarct Location |
| url | https://doi.org/10.1186/s12883-023-03075-z |
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