FBLIM1 mRNA is a novel prognostic biomarker and is associated with immune infiltrates in glioma
Glioma is the most common primary brain tumor. Filamin-binding LIM protein 1 (FBLIM1) has been identified in multiple cancers and is suspected of playing a part in the development of tumors. However, the potential function of FBLIM1 mRNA in glioma has not been investigated. In this study, the clinic...
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| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2023-12-01
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| Series: | Open Medicine |
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| Online Access: | https://doi.org/10.1515/med-2023-0863 |
| _version_ | 1797387355392311296 |
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| author | Deng Yifan Zeng Kailiang Wu Diancheng Ling Yunzhi Tian Yu Zheng Yi Fang Shumin Jiang Xiaocong Zhu Gang Tu Yanyang |
| author_facet | Deng Yifan Zeng Kailiang Wu Diancheng Ling Yunzhi Tian Yu Zheng Yi Fang Shumin Jiang Xiaocong Zhu Gang Tu Yanyang |
| author_sort | Deng Yifan |
| collection | DOAJ |
| description | Glioma is the most common primary brain tumor. Filamin-binding LIM protein 1 (FBLIM1) has been identified in multiple cancers and is suspected of playing a part in the development of tumors. However, the potential function of FBLIM1 mRNA in glioma has not been investigated. In this study, the clinical information and transcriptome data of glioma patients were, respectively, retrieved from the TCGA and CGGA databases. The expression level of FBLIM1 mRNA was shown to be aberrant in a wide variety of malignancies. Significantly, when glioma samples were compared to normal brain samples, FBLIM1 expression was shown to be significantly elevated in the former. A poor prognosis was related to high FBLIM1 expression, which was linked to more advanced clinical stages. Notably, multivariate analyses demonstrated that FBLIM1 expression was an independent predictor for the overall survival of glioma patients. Immune infiltration analysis disclosed that FBLIM1 expression had relevance with many immune cells. The results of RT-PCR suggested that FBLIM1 expression was markedly elevated in glioma specimens. Functional experiments unveiled that the knockdown of FBLIM1 mRNA suppressed glioma cell proliferation. In general, we initially discovered that FBLIM1 mRNA might be a possible prognostic marker in glioma. |
| first_indexed | 2024-03-08T22:22:58Z |
| format | Article |
| id | doaj.art-d3f09c886e0b49afb2c15bca6abef12c |
| institution | Directory Open Access Journal |
| issn | 2391-5463 |
| language | English |
| last_indexed | 2024-03-08T22:22:58Z |
| publishDate | 2023-12-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Open Medicine |
| spelling | doaj.art-d3f09c886e0b49afb2c15bca6abef12c2023-12-18T12:43:28ZengDe GruyterOpen Medicine2391-54632023-12-01181346810.1515/med-2023-0863FBLIM1 mRNA is a novel prognostic biomarker and is associated with immune infiltrates in gliomaDeng Yifan0Zeng Kailiang1Wu Diancheng2Ling Yunzhi3Tian Yu4Zheng Yi5Fang Shumin6Jiang Xiaocong7Zhu Gang8Tu Yanyang9Department of Neurosurgery, The Huizhou Central People’s Hospital, Guangdong Medical University, Huizhou, Guangdong, ChinaDepartment of Neurosurgery, The Huizhou Central People’s Hospital, Guangdong Medical University, Huizhou, Guangdong, ChinaDepartment of Neurosurgery, The Huizhou Central People’s Hospital, Guangdong Medical University, Huizhou, Guangdong, ChinaResearch Center, The Huizhou Central People’s Hospital, Guangdong Medical University, Huizhou, Guangdong, ChinaDepartment of Neurosurgery, The Huizhou Central People’s Hospital, Guangdong Medical University, Huizhou, Guangdong, ChinaResearch Center, The Huizhou Central People’s Hospital, Guangdong Medical University, Huizhou, Guangdong, ChinaResearch Center, The Huizhou Central People’s Hospital, Guangdong Medical University, Huizhou, Guangdong, ChinaDepartment of Radiotherapy, The Huizhou Central People’s Hospital, Guangdong Medical University, Huizhou, Guangdong, ChinaDepartment of Neurosurgery, The Huizhou Central People’s Hospital, Guangdong Medical University, Huizhou, Guangdong, ChinaResearch Center, The Huizhou Central People’s Hospital, Guangdong Medical University, Huizhou, Guangdong, ChinaGlioma is the most common primary brain tumor. Filamin-binding LIM protein 1 (FBLIM1) has been identified in multiple cancers and is suspected of playing a part in the development of tumors. However, the potential function of FBLIM1 mRNA in glioma has not been investigated. In this study, the clinical information and transcriptome data of glioma patients were, respectively, retrieved from the TCGA and CGGA databases. The expression level of FBLIM1 mRNA was shown to be aberrant in a wide variety of malignancies. Significantly, when glioma samples were compared to normal brain samples, FBLIM1 expression was shown to be significantly elevated in the former. A poor prognosis was related to high FBLIM1 expression, which was linked to more advanced clinical stages. Notably, multivariate analyses demonstrated that FBLIM1 expression was an independent predictor for the overall survival of glioma patients. Immune infiltration analysis disclosed that FBLIM1 expression had relevance with many immune cells. The results of RT-PCR suggested that FBLIM1 expression was markedly elevated in glioma specimens. Functional experiments unveiled that the knockdown of FBLIM1 mRNA suppressed glioma cell proliferation. In general, we initially discovered that FBLIM1 mRNA might be a possible prognostic marker in glioma.https://doi.org/10.1515/med-2023-0863fblim1 mrnaimmune cell infiltrationprognosisbiomarkerbioinformatics analysisglioma |
| spellingShingle | Deng Yifan Zeng Kailiang Wu Diancheng Ling Yunzhi Tian Yu Zheng Yi Fang Shumin Jiang Xiaocong Zhu Gang Tu Yanyang FBLIM1 mRNA is a novel prognostic biomarker and is associated with immune infiltrates in glioma Open Medicine fblim1 mrna immune cell infiltration prognosis biomarker bioinformatics analysis glioma |
| title | FBLIM1 mRNA is a novel prognostic biomarker and is associated with immune infiltrates in glioma |
| title_full | FBLIM1 mRNA is a novel prognostic biomarker and is associated with immune infiltrates in glioma |
| title_fullStr | FBLIM1 mRNA is a novel prognostic biomarker and is associated with immune infiltrates in glioma |
| title_full_unstemmed | FBLIM1 mRNA is a novel prognostic biomarker and is associated with immune infiltrates in glioma |
| title_short | FBLIM1 mRNA is a novel prognostic biomarker and is associated with immune infiltrates in glioma |
| title_sort | fblim1 mrna is a novel prognostic biomarker and is associated with immune infiltrates in glioma |
| topic | fblim1 mrna immune cell infiltration prognosis biomarker bioinformatics analysis glioma |
| url | https://doi.org/10.1515/med-2023-0863 |
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