Chitosan oligomer/silver nanoparticles/PCL composite electrospun membrane for severe burn wound healing
In the management of burn wounds, antimicrobial and wound healing properties are crucial. In this study, we prepared a three-layer electrospun poly(ε-caprolactone) (PCL) membrane for burn wound dressing. The hydrophobic electrospun PCL layer, embedded with silver nanoparticles (SNPs) (PCL-Ag), was...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Vietnam Ministry of Science and Technology
2023-12-01
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| Series: | Vietnam Journal of Science, Technology and Engineering |
| Subjects: | |
| Online Access: | https://vietnamscience.vjst.vn/index.php/vjste/article/view/1171 |
| _version_ | 1827583090619318272 |
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| author | Anh Mai Que Tuan Ngan Tang Tam Phan Thi Thanh Thanh Tu Duong Thanh Binh Vu Van Khiem Nguyen Hoan Ngoc Doan Hiep Thi Nguyen |
| author_facet | Anh Mai Que Tuan Ngan Tang Tam Phan Thi Thanh Thanh Tu Duong Thanh Binh Vu Van Khiem Nguyen Hoan Ngoc Doan Hiep Thi Nguyen |
| author_sort | Anh Mai Que |
| collection | DOAJ |
| description |
In the management of burn wounds, antimicrobial and wound healing properties are crucial. In this study, we prepared a three-layer electrospun poly(ε-caprolactone) (PCL) membrane for burn wound dressing. The hydrophobic electrospun PCL layer, embedded with silver nanoparticles (SNPs) (PCL-Ag), was coated with another layer of electrospun plasma-treated PCL- Ag to enhance the wettability of the membrane. This enhancement was to facilitate the absorption of the hydrophilic chitosan oligomer (COS) - the third layer of the dressing. The resultant membranes were characterised and tested for different properties to demonstrate their applicability as wound dressing materials. The combination of COS and SNPs of the fabricated membrane supports the healing process and reduces burn severity due to the healing capacity of COS and the antibacterial activity of SNPs, without compromising mechanical strength. We conducted several in vitro and in vivo experiments to evaluate its applicability for burn wound healing. The PCL-Ag/COS sample demonstrated outstanding in vitro biocompatibility and excellent antibacterial activity against Staphylococcus aureus strains. We used the membrane to treat burns on rabbits in the laboratory over 30 days, and consistently observed positive outcomes. This research offers insights into the development of bioactive dressings for wound healing and opens up opportunities for practical applications of COS-incorporated materials.
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| first_indexed | 2024-03-08T23:00:53Z |
| format | Article |
| id | doaj.art-d3f13c433877441091a1d94f25a2408d |
| institution | Directory Open Access Journal |
| issn | 2525-2461 2615-9937 |
| language | English |
| last_indexed | 2024-03-08T23:00:53Z |
| publishDate | 2023-12-01 |
| publisher | Vietnam Ministry of Science and Technology |
| record_format | Article |
| series | Vietnam Journal of Science, Technology and Engineering |
| spelling | doaj.art-d3f13c433877441091a1d94f25a2408d2023-12-15T22:34:50ZengVietnam Ministry of Science and TechnologyVietnam Journal of Science, Technology and Engineering2525-24612615-99372023-12-01654Chitosan oligomer/silver nanoparticles/PCL composite electrospun membrane for severe burn wound healingAnh Mai QueTuan Ngan TangTam Phan Thi ThanhThanh Tu DuongThanh Binh VuVan Khiem NguyenHoan Ngoc DoanHiep Thi Nguyen In the management of burn wounds, antimicrobial and wound healing properties are crucial. In this study, we prepared a three-layer electrospun poly(ε-caprolactone) (PCL) membrane for burn wound dressing. The hydrophobic electrospun PCL layer, embedded with silver nanoparticles (SNPs) (PCL-Ag), was coated with another layer of electrospun plasma-treated PCL- Ag to enhance the wettability of the membrane. This enhancement was to facilitate the absorption of the hydrophilic chitosan oligomer (COS) - the third layer of the dressing. The resultant membranes were characterised and tested for different properties to demonstrate their applicability as wound dressing materials. The combination of COS and SNPs of the fabricated membrane supports the healing process and reduces burn severity due to the healing capacity of COS and the antibacterial activity of SNPs, without compromising mechanical strength. We conducted several in vitro and in vivo experiments to evaluate its applicability for burn wound healing. The PCL-Ag/COS sample demonstrated outstanding in vitro biocompatibility and excellent antibacterial activity against Staphylococcus aureus strains. We used the membrane to treat burns on rabbits in the laboratory over 30 days, and consistently observed positive outcomes. This research offers insights into the development of bioactive dressings for wound healing and opens up opportunities for practical applications of COS-incorporated materials. https://vietnamscience.vjst.vn/index.php/vjste/article/view/1171antibacterial wound dressingelectrospun membraneoligomer chitosanpolycaprolactoneSNPs |
| spellingShingle | Anh Mai Que Tuan Ngan Tang Tam Phan Thi Thanh Thanh Tu Duong Thanh Binh Vu Van Khiem Nguyen Hoan Ngoc Doan Hiep Thi Nguyen Chitosan oligomer/silver nanoparticles/PCL composite electrospun membrane for severe burn wound healing Vietnam Journal of Science, Technology and Engineering antibacterial wound dressing electrospun membrane oligomer chitosan polycaprolactone SNPs |
| title | Chitosan oligomer/silver nanoparticles/PCL composite electrospun membrane for severe burn wound healing |
| title_full | Chitosan oligomer/silver nanoparticles/PCL composite electrospun membrane for severe burn wound healing |
| title_fullStr | Chitosan oligomer/silver nanoparticles/PCL composite electrospun membrane for severe burn wound healing |
| title_full_unstemmed | Chitosan oligomer/silver nanoparticles/PCL composite electrospun membrane for severe burn wound healing |
| title_short | Chitosan oligomer/silver nanoparticles/PCL composite electrospun membrane for severe burn wound healing |
| title_sort | chitosan oligomer silver nanoparticles pcl composite electrospun membrane for severe burn wound healing |
| topic | antibacterial wound dressing electrospun membrane oligomer chitosan polycaprolactone SNPs |
| url | https://vietnamscience.vjst.vn/index.php/vjste/article/view/1171 |
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