In vitro activity of Ricinus communis (castor oil) on cysts of Entamoeba histolytica
Background: No descriptions in scientific literature exist about anti Entamoeba histolytica effect of Ricinus communis although is used by traditional medicine in Latin America for treatment or prophylaxis of intestinal amebiasis. Purpose: To evaluate the in vitro cysticidal effect of castor oil ext...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-05-01
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| Series: | Phytomedicine Plus |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667031324000162 |
| _version_ | 1797296237372768256 |
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| author | Deicy Muñoz-Sánchez Yimmi Pinto Juan David Valencia-Hernandez Fabiana Lora-Suarez Jose Miguel Sanchez Jorge Enrique Gómez-Marín |
| author_facet | Deicy Muñoz-Sánchez Yimmi Pinto Juan David Valencia-Hernandez Fabiana Lora-Suarez Jose Miguel Sanchez Jorge Enrique Gómez-Marín |
| author_sort | Deicy Muñoz-Sánchez |
| collection | DOAJ |
| description | Background: No descriptions in scientific literature exist about anti Entamoeba histolytica effect of Ricinus communis although is used by traditional medicine in Latin America for treatment or prophylaxis of intestinal amebiasis. Purpose: To evaluate the in vitro cysticidal effect of castor oil extracts available as regulated phytotherapeutic products against E. histolytica. Study design: In vitro evaluation of the cysticidal effect against E. histolytica of R. communis oil extracts. Methods: We analyzed the effects of three commercial castor oil compounds on the viability and morphology of E. histolytica cysts. Results: The three samples had significant cysticidal effects and altered cyst morphology after 10 h of exposure. The effective dose 50 % (EC50) ranged between 35 and 50 μg/ml, with a range of estimated EC50 25 and 35 μg/ml in the human intestine in vivo. Conclusion: Castor oil pharmaceutical products have good in vitro anti-E. histolytica, which requires clinical trials to confirm its anti-amoebic effect. |
| first_indexed | 2024-03-07T22:00:31Z |
| format | Article |
| id | doaj.art-d3f3e1d9447c46329673445a1f057255 |
| institution | Directory Open Access Journal |
| issn | 2667-0313 |
| language | English |
| last_indexed | 2024-03-07T22:00:31Z |
| publishDate | 2024-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Phytomedicine Plus |
| spelling | doaj.art-d3f3e1d9447c46329673445a1f0572552024-02-24T04:55:42ZengElsevierPhytomedicine Plus2667-03132024-05-0142100538In vitro activity of Ricinus communis (castor oil) on cysts of Entamoeba histolyticaDeicy Muñoz-Sánchez0Yimmi Pinto1Juan David Valencia-Hernandez2Fabiana Lora-Suarez3Jose Miguel Sanchez4Jorge Enrique Gómez-Marín5Universidad del Quindío, Molecular Parasitology Study Group (GEPAMOL), Carrera 15, Calle 12N, COL, 630003, ArmeniaUniversidad del Quindío, Molecular Parasitology Study Group (GEPAMOL), Carrera 15, Calle 12N, COL, 630003, ArmeniaUniversidad del Quindío, Molecular Parasitology Study Group (GEPAMOL), Carrera 15, Calle 12N, COL, 630003, ArmeniaUniversidad del Quindío, Molecular Parasitology Study Group (GEPAMOL), Carrera 15, Calle 12N, COL, 630003, ArmeniaLaboratorios El Mana, Cl. 74a # 83-59, Engativá, Bogotá, Cundinamarca, Colombia; Universidad Antonio Nariño, Facultad de Ciencias, Departamento de Química, ColombiaUniversidad del Quindío, Molecular Parasitology Study Group (GEPAMOL), Carrera 15, Calle 12N, COL, 630003, Armenia; Corresponding author at: GEPAMOL, Centro de Investigaciones Biomédicas, Universidad del Quindío, Armenia, Quindío, 630004, Colombia.Background: No descriptions in scientific literature exist about anti Entamoeba histolytica effect of Ricinus communis although is used by traditional medicine in Latin America for treatment or prophylaxis of intestinal amebiasis. Purpose: To evaluate the in vitro cysticidal effect of castor oil extracts available as regulated phytotherapeutic products against E. histolytica. Study design: In vitro evaluation of the cysticidal effect against E. histolytica of R. communis oil extracts. Methods: We analyzed the effects of three commercial castor oil compounds on the viability and morphology of E. histolytica cysts. Results: The three samples had significant cysticidal effects and altered cyst morphology after 10 h of exposure. The effective dose 50 % (EC50) ranged between 35 and 50 μg/ml, with a range of estimated EC50 25 and 35 μg/ml in the human intestine in vivo. Conclusion: Castor oil pharmaceutical products have good in vitro anti-E. histolytica, which requires clinical trials to confirm its anti-amoebic effect.http://www.sciencedirect.com/science/article/pii/S2667031324000162Ricinus communisCastor oilAnti-amoebicNatural compoundsPhytotherapyEntamoeba histolytica |
| spellingShingle | Deicy Muñoz-Sánchez Yimmi Pinto Juan David Valencia-Hernandez Fabiana Lora-Suarez Jose Miguel Sanchez Jorge Enrique Gómez-Marín In vitro activity of Ricinus communis (castor oil) on cysts of Entamoeba histolytica Phytomedicine Plus Ricinus communis Castor oil Anti-amoebic Natural compounds Phytotherapy Entamoeba histolytica |
| title | In vitro activity of Ricinus communis (castor oil) on cysts of Entamoeba histolytica |
| title_full | In vitro activity of Ricinus communis (castor oil) on cysts of Entamoeba histolytica |
| title_fullStr | In vitro activity of Ricinus communis (castor oil) on cysts of Entamoeba histolytica |
| title_full_unstemmed | In vitro activity of Ricinus communis (castor oil) on cysts of Entamoeba histolytica |
| title_short | In vitro activity of Ricinus communis (castor oil) on cysts of Entamoeba histolytica |
| title_sort | in vitro activity of ricinus communis castor oil on cysts of entamoeba histolytica |
| topic | Ricinus communis Castor oil Anti-amoebic Natural compounds Phytotherapy Entamoeba histolytica |
| url | http://www.sciencedirect.com/science/article/pii/S2667031324000162 |
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