Melanogenesis Is Directly Affected by Metabolites of Melatonin in Human Melanoma Cells

Melanogenesis Is Directly Affected by Metabolites of Melatonin in Human Melanoma Cells

Melatonin (<i>N</i>-acetyl-5-methoxytryptamine, MEL), its kynurenic (<i>N</i><sup>1</sup>-acetyl-<i>N</i><sup>2</sup>-formyl-5-methoxykynurenine, AFMK) and indolic derivatives (6-hydroxymelatonin, 6(OH)MEL and 5-methoxytryptamine, 5-MT) are...

Full description

Bibliographic Details
Main Authors:	Jack K. S. Möller, Kinga Linowiecka, Maciej Gagat, Anna A. Brożyna, Marek Foksiński, Agnieszka Wolnicka-Glubisz, Elżbieta Pyza, Russel J. Reiter, Meri K. Tulic, Andrzej T. Slominski, Kerstin Steinbrink, Konrad Kleszczyński
Format:	Article
Language:	English
Published:	MDPI AG 2023-10-01
Series:	International Journal of Molecular Sciences
Subjects:	melatonin melanogenesis kynurenic and indolic metabolites tyrosinase human melanoma G-protein-coupled membrane receptors
Online Access:	https://www.mdpi.com/1422-0067/24/19/14947

Similar Items

Ultraviolet Radiation-Induced Mitochondrial Disturbances Are Attenuated by Metabolites of Melatonin in Human Epidermal Keratinocytes
by: Chantal E. Holtkamp, et al.
Published: (2023-07-01)

Melatonin Induces Melanogenesis in Human SK-MEL-1 Melanoma Cells Involving Glycogen Synthase Kinase-3 and Reactive Oxygen Species
by: Juan Perdomo, et al.
Published: (2020-07-01)

Brassinin Abundant in Brassicaceae Suppresses Melanogenesis through Dual Mechanisms of Tyrosinase Inhibition
by: Min-Kyeong Lee, et al.
Published: (2022-12-01)

Inhibitory Effect and Mechanism of Scutellarein on Melanogenesis
by: Liyun Dai, et al.
Published: (2021-02-01)

Maclurin Exhibits Antioxidant and Anti-Tyrosinase Activities, Suppressing Melanogenesis
by: Kyoung Mi Moon, et al.
Published: (2022-06-01)

Melatonin: A Potential Regulator of DNA Methylation
by: Kinga Linowiecka, et al.
Published: (2023-05-01)

Molecular Analysis of the Melanogenesis Inhibitory Effect of Saponins-Rich Fraction of <i>Argania spinosa</i> Leaves Extract
by: Myra O. Villareal, et al.
Published: (2022-10-01)

Elucidation of Melanogenesis Cascade for Identifying Pathophysiology and Therapeutic Approach of Pigmentary Disorders and Melanoma
by: Tokimasa Hida, et al.
Published: (2020-08-01)

Clinical Trials for Use of Melatonin to Fight against COVID-19 Are Urgently Needed
by: Konrad Kleszczyński, et al.
Published: (2020-08-01)

Inhibition of melanogenesis and antioxidant properties of <it>Magnolia grandiflora</it> L. flower extract
by: Huang Huey-Chun, et al.
Published: (2012-06-01)

Exploration of Mechanistic Insights of Acemetacin in Melanogenesis Through Zebrafish Model, Enzyme Kinetics, Molecular Docking and Simulation Approaches
by: Hussain Raza, et al.
Published: (2020-06-01)

Tyrosinase and Melanogenesis Inhibition by Indigenous African Plants: A Review
by: Laurentia Opperman, et al.
Published: (2020-07-01)

The Anti-melanogenesis Activities of Some Selected Brown Macroalgae from Northern Coasts of the Persian Gulf
by: Foroogh Namjooyan, et al.

Development of highly potent melanogenesis inhibitor by in vitro, in vivo and computational studies
by: Abbas Q, et al.
Published: (2017-07-01)

Modified Riceberry rice extract suppresses melanogenesis-associated cell differentiation through tyrosinase-mediated MITF downregulation on B16 cells and in vivo zebrafish embryos
by: Teerapat Rodboon, et al.
Published: (2020-01-01)

Differential and Overlapping Effects of Melatonin and Its Metabolites on Keratinocyte Function: Bioinformatics and Metabolic Analyses
by: Joanna Stefan, et al.
Published: (2021-04-01)

Influence of Four Phlomis Species on Melanogenesis in Human Malignant Melanoma (SKMEL-3) Cells
by: Parisa Sarkhail*, et al.
Published: (2019-04-01)

Melanoma, Melanin, and Melanogenesis: The Yin and Yang Relationship
by: Radomir M. Slominski, et al.
Published: (2022-03-01)

Effect of Chlorogenic Acid on Melanogenesis of B16 Melanoma Cells
by: Hao-Rong Li, et al.
Published: (2014-08-01)

Anti-melanogenesis and anti-tyrosinase properties of Pistacia atlantica subsp. mutica extracts on B16F10 murine melanoma cells
by: Samira Eghbali-Feriz, et al.
Published: (2018-01-01)

Membrane-Associated Ubiquitin Ligase RING Finger Protein 152 Orchestrates Melanogenesis via Tyrosinase Ubiquitination
by: Ryota Ueda, et al.
Published: (2024-02-01)

New Benzimidazothiazolone Derivatives as Tyrosinase Inhibitors with Potential Anti-Melanogenesis and Reactive Oxygen Species Scavenging Activities
by: Hee Jin Jung, et al.
Published: (2021-07-01)

Germinated Riceberry Rice Enhanced Protocatechuic Acid and Vanillic Acid to Suppress Melanogenesis through Cellular Oxidant-Related Tyrosinase Activity in B16 Cells
by: Teerapat Rodboon, et al.
Published: (2020-03-01)

Characterization of Melanogenesis Inhibitory Constituents of Morus alba Leaves and Optimization of Extraction Conditions Using Response Surface Methodology
by: Ji Yeon Jeong, et al.
Published: (2015-05-01)

Melatonin and TGF-β-Mediated Release of Extracellular Vesicles
by: Klaudia Piekarska, et al.
Published: (2023-04-01)

The 308-nm excimer laser stimulates melanogenesis via the wnt/β-Catenin signaling pathway in B16 cells
by: Lili Li, et al.
Published: (2019-11-01)

(<i>E</i>)-1-(Furan-2-yl)-(substituted phenyl)prop-2-en-1-one Derivatives as Tyrosinase Inhibitors and Melanogenesis Inhibition: An In Vitro and In Silico Study
by: Hee Jin Jung, et al.
Published: (2020-11-01)

Evaluation of Polymeric Matrix Loaded with Melatonin for Wound Dressing
by: Beata Kaczmarek-Szczepańska, et al.
Published: (2021-05-01)

<i>Pleurochrysis carterae</i> Hot-Water Extract Inhibits Melanogenesis in Murine Melanoma Cells
by: Kazuomi Sato, et al.
Published: (2019-10-01)

Induction of Melanogenesis by Fosfomycin in B16F10 Cells Through the Upregulation of P-JNK and P-p38 Signaling Pathways
by: Sana Ullah, et al.
Published: (2020-04-01)

GIF-2209, an Oxindole Derivative, Accelerates Melanogenesis and Melanosome Secretion via the Modification of Lysosomes in B16F10 Mouse Melanoma Cells
by: Miyu Watanabe, et al.
Published: (2021-12-01)

The Skin-Whitening Effects of Ectoine via the Suppression of α-MSH-Stimulated Melanogenesis and the Activation of Antioxidant Nrf2 Pathways in UVA-Irradiated Keratinocytes
by: You-Cheng Hseu, et al.
Published: (2020-01-01)

α-Mangostin suppressed melanogenesis in B16F10 murine melanoma cells through GSK3β and ERK signaling pathway
by: Siqi Zhou, et al.
Published: (2021-07-01)

Antioxidation and Melanogenesis Inhibition of Various Dendrobium tosaense Extracts
by: Chin-Feng Chan, et al.
Published: (2018-07-01)

Upregulation of Melanogenesis and Tyrosinase Activity: Potential Agents for Vitiligo
by: Chao Niu, et al.
Published: (2017-08-01)

Tyrosinase Inhibitors: A Perspective
by: Mason A. Baber, et al.
Published: (2023-07-01)

The Biochemical and Molecular Analysis of Changes in Melanogenesis Induced by UVA-Activated Fluoroquinolones—In Vitro Study on Human Normal Melanocytes
by: Justyna Kowalska, et al.
Published: (2021-10-01)

Inhibitory Effect of Curcumin-Inspired Derivatives on Tyrosinase Activity and Melanogenesis
by: Gaia Rocchitta, et al.
Published: (2022-11-01)

Molecular mechanisms underlying Tao-Hong-Si-Wu decoction treating hyperpigmentation based on network pharmacology, Mendelian randomization analysis, and experimental verification
by: Jun Chen, et al.
Published: (2024-12-01)

Identification of Anti-Melanogenesis Constituents from Morus alba L. Leaves
by: Hong Xu Li, et al.
Published: (2018-10-01)