CYP1A2 expression rather than genotype is associated with olanzapine concentration in psychiatric patients

CYP1A2 expression rather than genotype is associated with olanzapine concentration in psychiatric patients

Abstract Olanzapine is a commonly prescribed atypical antipsychotic agent for treatment of patients with schizophrenia and bipolar disorders. Previous in vitro studies using human liver microsomes identified CYP1A2 and CYP2D6 enzymes being responsible for CYP-mediated metabolism of olanzapine. The p...

Full description

Bibliographic Details
Main Authors: Ferenc Fekete, Ádám Menus, Katalin Tóth, Ádám Ferenc Kiss, Annamária Minus, Dávid Sirok, Aleš Belič, Ádám Póti, Gábor Csukly, Katalin Monostory
Format: Article
Language:English
Published: Nature Portfolio 2023-10-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-45752-6

Similar Items

Similar Items