Myelin and Modeling: Bootstrapping Cortical Microcircuits
Histological studies of myelin-stained sectioned cadaver brain and in vivo myelin-weighted magnetic resonance imaging (MRI) show that the cerebral cortex is organized into cortical areas with generally well-defined boundaries, which have consistent internal patterns of myelination. The process of my...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-05-01
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| Series: | Frontiers in Neural Circuits |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fncir.2019.00034/full |
| _version_ | 1819031214718189568 |
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| author | Robert Turner Robert Turner Robert Turner |
| author_facet | Robert Turner Robert Turner Robert Turner |
| author_sort | Robert Turner |
| collection | DOAJ |
| description | Histological studies of myelin-stained sectioned cadaver brain and in vivo myelin-weighted magnetic resonance imaging (MRI) show that the cerebral cortex is organized into cortical areas with generally well-defined boundaries, which have consistent internal patterns of myelination. The process of myelination is largely driven by neural experience, in which the axonal passage of action potentials stimulates neighboring oligodendrocytes to perform their task. This bootstrapping process, such that the traffic of action potentials facilitates increased traffic, suggests the hypothesis that the specific pattern of myelination (myeloarchitecture) in each cortical area reveals the principal cortical microcircuits required for the function of that area. If this idea is correct, the observable sequential maturation of specific brain areas can provide evidence for models of the stages of cognitive development. |
| first_indexed | 2024-12-21T06:42:30Z |
| format | Article |
| id | doaj.art-d3f819522a7d4fbe9852dbe30fdb23d2 |
| institution | Directory Open Access Journal |
| issn | 1662-5110 |
| language | English |
| last_indexed | 2024-12-21T06:42:30Z |
| publishDate | 2019-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neural Circuits |
| spelling | doaj.art-d3f819522a7d4fbe9852dbe30fdb23d22022-12-21T19:12:41ZengFrontiers Media S.A.Frontiers in Neural Circuits1662-51102019-05-011310.3389/fncir.2019.00034459175Myelin and Modeling: Bootstrapping Cortical MicrocircuitsRobert Turner0Robert Turner1Robert Turner2Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, GermanySir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United KingdomSpinoza Centre for Neuroimaging, University of Amsterdam, Amsterdam, NetherlandsHistological studies of myelin-stained sectioned cadaver brain and in vivo myelin-weighted magnetic resonance imaging (MRI) show that the cerebral cortex is organized into cortical areas with generally well-defined boundaries, which have consistent internal patterns of myelination. The process of myelination is largely driven by neural experience, in which the axonal passage of action potentials stimulates neighboring oligodendrocytes to perform their task. This bootstrapping process, such that the traffic of action potentials facilitates increased traffic, suggests the hypothesis that the specific pattern of myelination (myeloarchitecture) in each cortical area reveals the principal cortical microcircuits required for the function of that area. If this idea is correct, the observable sequential maturation of specific brain areas can provide evidence for models of the stages of cognitive development.https://www.frontiersin.org/article/10.3389/fncir.2019.00034/fullbrainmyelinMRIcortical microcircuitrydevelomentmodeling |
| spellingShingle | Robert Turner Robert Turner Robert Turner Myelin and Modeling: Bootstrapping Cortical Microcircuits Frontiers in Neural Circuits brain myelin MRI cortical microcircuitry develoment modeling |
| title | Myelin and Modeling: Bootstrapping Cortical Microcircuits |
| title_full | Myelin and Modeling: Bootstrapping Cortical Microcircuits |
| title_fullStr | Myelin and Modeling: Bootstrapping Cortical Microcircuits |
| title_full_unstemmed | Myelin and Modeling: Bootstrapping Cortical Microcircuits |
| title_short | Myelin and Modeling: Bootstrapping Cortical Microcircuits |
| title_sort | myelin and modeling bootstrapping cortical microcircuits |
| topic | brain myelin MRI cortical microcircuitry develoment modeling |
| url | https://www.frontiersin.org/article/10.3389/fncir.2019.00034/full |
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