Epidemic Keratoconjunctivitis-Causing Adenoviruses Induce MUC16 Ectodomain Release To Infect Ocular Surface Epithelial Cells

Epidemic Keratoconjunctivitis-Causing Adenoviruses Induce MUC16 Ectodomain Release To Infect Ocular Surface Epithelial Cells

ABSTRACT Human adenoviruses (HAdV), species D in particular (HAdV-D), are frequently associated with epidemic keratoconjunctivitis (EKC). Although the infection originates at the ocular surface epithelium, the mechanisms by which HAdV-Ds bypass the membrane-associated mucin (MAM)-rich glycocalyx of...

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Bibliographic Details
Main Authors: Balaraj B. Menon, Xiaohong Zhou, Sandra Spurr-Michaud, Jaya Rajaiya, James Chodosh, Ilene K. Gipson
Format: Article
Language:English
Published: American Society for Microbiology 2016-02-01
Series:mSphere
Subjects:
adenoviruses
keratoconjunctivitis
mucin
Online Access:https://journals.asm.org/doi/10.1128/mSphere.00112-15

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