The bioenergetic “CK Clamp” technique detects substrate-specific changes in mitochondrial respiration and membrane potential during early VML injury pathology

The bioenergetic “CK Clamp” technique detects substrate-specific changes in mitochondrial respiration and membrane potential during early VML injury pathology

Volumetric muscle loss (VML) injuries are characterized by non-recoverable loss of tissue resulting in contractile and metabolic dysfunction. The characterization of metabolic dysfunction in volumetric muscle loss-injured muscle has been interpreted from permeabilized myofiber respiration experiment...

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Bibliographic Details
Main Authors: Jennifer McFaline-Figueroa, Edward T. Hunda, Junwon Heo, Elizabeth A. Winders, Sarah M. Greising, Jarrod A. Call
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Physiology
Subjects:
muscle metabolism
muscle bioenergetics
muscle injury
oroboros oxygraph 2K
HORIBA
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2023.1178213/full

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