Instability in the COPD diagnosis upon repeat testing vary with the definition of COPD.
A low FEV1/FVC from post-bronchodilator spirometry is required to diagnose COPD. Both the FEV1 and the FVC can vary over time; therefore, individuals can be given a diagnosis of mild COPD at one visit, but have normal spirometry during the next appointment, even without an intervention.We analyzed t...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2015-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4374954?pdf=render |
| _version_ | 1811277529706659840 |
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| author | Rogelio Perez-Padilla Fernando C Wehrmeister Maria Montes de Oca Maria Victorina Lopez Jose R Jardim Adriana Muino Gonzalo Valdivia Julio Pertuze Ana Maria B Menezes PLATINO group |
| author_facet | Rogelio Perez-Padilla Fernando C Wehrmeister Maria Montes de Oca Maria Victorina Lopez Jose R Jardim Adriana Muino Gonzalo Valdivia Julio Pertuze Ana Maria B Menezes PLATINO group |
| author_sort | Rogelio Perez-Padilla |
| collection | DOAJ |
| description | A low FEV1/FVC from post-bronchodilator spirometry is required to diagnose COPD. Both the FEV1 and the FVC can vary over time; therefore, individuals can be given a diagnosis of mild COPD at one visit, but have normal spirometry during the next appointment, even without an intervention.We analyzed two population-based surveys of adults with spirometry carried out for the same individuals 5-9 years after their baseline examination. We determined the factors associated with a change in the spirometry interpretation from one exam to the next utilizing different criteria commonly used to diagnose COPD.The rate of an inconsistent diagnosis of mild COPD was 11.7% using FEV1/FVC <0.70, 5.9% using FEV1/FEV6 <the lower limit of the normal range, LLN and 4.1% using the GOLD stage 2-4 criterion. The most important factor associated with diagnostic inconsistency was the closeness of the ratio to the LLN during the first examination. Inconsistency decreased with a lower FEV1.Using FEV1/FEV6 <LLN or GOLD stage 2-4 as the criterion for airflow obstruction reduces inconsistencies in the diagnosis of mild COPD. Further improvement could be obtained by defining a borderline zone around the LLN (e.g. plus or minus 0.6 SD), or repeating the test in patients with borderline results. |
| first_indexed | 2024-04-13T00:17:19Z |
| format | Article |
| id | doaj.art-d3fe4e2669d045cc9153344b99cb5d92 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-13T00:17:19Z |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-d3fe4e2669d045cc9153344b99cb5d922022-12-22T03:10:53ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01103e012183210.1371/journal.pone.0121832Instability in the COPD diagnosis upon repeat testing vary with the definition of COPD.Rogelio Perez-PadillaFernando C WehrmeisterMaria Montes de OcaMaria Victorina LopezJose R JardimAdriana MuinoGonzalo ValdiviaJulio PertuzeAna Maria B MenezesPLATINO groupA low FEV1/FVC from post-bronchodilator spirometry is required to diagnose COPD. Both the FEV1 and the FVC can vary over time; therefore, individuals can be given a diagnosis of mild COPD at one visit, but have normal spirometry during the next appointment, even without an intervention.We analyzed two population-based surveys of adults with spirometry carried out for the same individuals 5-9 years after their baseline examination. We determined the factors associated with a change in the spirometry interpretation from one exam to the next utilizing different criteria commonly used to diagnose COPD.The rate of an inconsistent diagnosis of mild COPD was 11.7% using FEV1/FVC <0.70, 5.9% using FEV1/FEV6 <the lower limit of the normal range, LLN and 4.1% using the GOLD stage 2-4 criterion. The most important factor associated with diagnostic inconsistency was the closeness of the ratio to the LLN during the first examination. Inconsistency decreased with a lower FEV1.Using FEV1/FEV6 <LLN or GOLD stage 2-4 as the criterion for airflow obstruction reduces inconsistencies in the diagnosis of mild COPD. Further improvement could be obtained by defining a borderline zone around the LLN (e.g. plus or minus 0.6 SD), or repeating the test in patients with borderline results.http://europepmc.org/articles/PMC4374954?pdf=render |
| spellingShingle | Rogelio Perez-Padilla Fernando C Wehrmeister Maria Montes de Oca Maria Victorina Lopez Jose R Jardim Adriana Muino Gonzalo Valdivia Julio Pertuze Ana Maria B Menezes PLATINO group Instability in the COPD diagnosis upon repeat testing vary with the definition of COPD. PLoS ONE |
| title | Instability in the COPD diagnosis upon repeat testing vary with the definition of COPD. |
| title_full | Instability in the COPD diagnosis upon repeat testing vary with the definition of COPD. |
| title_fullStr | Instability in the COPD diagnosis upon repeat testing vary with the definition of COPD. |
| title_full_unstemmed | Instability in the COPD diagnosis upon repeat testing vary with the definition of COPD. |
| title_short | Instability in the COPD diagnosis upon repeat testing vary with the definition of COPD. |
| title_sort | instability in the copd diagnosis upon repeat testing vary with the definition of copd |
| url | http://europepmc.org/articles/PMC4374954?pdf=render |
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