Topography: A Biophysical Approach to Direct the Fate of Mesenchymal Stem Cells in Tissue Engineering Applications
Tissue engineering is a promising strategy to treat tissue and organ loss or damage caused by injury or disease. During the past two decades, mesenchymal stem cells (MSCs) have attracted a tremendous amount of interest in tissue engineering due to their multipotency and self-renewal ability. MSCs ar...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-10-01
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| Series: | Nanomaterials |
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| Online Access: | https://www.mdpi.com/2079-4991/10/10/2070 |
| _version_ | 1827703952838230016 |
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| author | Xingli Cun Leticia Hosta-Rigau |
| author_facet | Xingli Cun Leticia Hosta-Rigau |
| author_sort | Xingli Cun |
| collection | DOAJ |
| description | Tissue engineering is a promising strategy to treat tissue and organ loss or damage caused by injury or disease. During the past two decades, mesenchymal stem cells (MSCs) have attracted a tremendous amount of interest in tissue engineering due to their multipotency and self-renewal ability. MSCs are also the most multipotent stem cells in the human adult body. However, the application of MSCs in tissue engineering is relatively limited because it is difficult to guide their differentiation toward a specific cell lineage by using traditional biochemical factors. Besides biochemical factors, the differentiation of MSCs also influenced by biophysical cues. To this end, much effort has been devoted to directing the cell lineage decisions of MSCs through adjusting the biophysical properties of biomaterials. The surface topography of the biomaterial-based scaffold can modulate the proliferation and differentiation of MSCs. Presently, the development of micro- and nano-fabrication techniques has made it possible to control the surface topography of the scaffold precisely. In this review, we highlight and discuss how the main topographical features (i.e., roughness, patterns, and porosity) are an efficient approach to control the fate of MSCs and the application of topography in tissue engineering. |
| first_indexed | 2024-03-10T15:30:00Z |
| format | Article |
| id | doaj.art-d3fe515fc9d54507b3c2d814ea885546 |
| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-03-10T15:30:00Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj.art-d3fe515fc9d54507b3c2d814ea8855462023-11-20T17:47:26ZengMDPI AGNanomaterials2079-49912020-10-011010207010.3390/nano10102070Topography: A Biophysical Approach to Direct the Fate of Mesenchymal Stem Cells in Tissue Engineering ApplicationsXingli Cun0Leticia Hosta-Rigau1DTU Health Tech, Centre for Nanomedicine and Theranostics, Technical University of Denmark, Nils Koppels Allé, Building 423, 2800 Kgs. Lyngby, DenmarkDTU Health Tech, Centre for Nanomedicine and Theranostics, Technical University of Denmark, Nils Koppels Allé, Building 423, 2800 Kgs. Lyngby, DenmarkTissue engineering is a promising strategy to treat tissue and organ loss or damage caused by injury or disease. During the past two decades, mesenchymal stem cells (MSCs) have attracted a tremendous amount of interest in tissue engineering due to their multipotency and self-renewal ability. MSCs are also the most multipotent stem cells in the human adult body. However, the application of MSCs in tissue engineering is relatively limited because it is difficult to guide their differentiation toward a specific cell lineage by using traditional biochemical factors. Besides biochemical factors, the differentiation of MSCs also influenced by biophysical cues. To this end, much effort has been devoted to directing the cell lineage decisions of MSCs through adjusting the biophysical properties of biomaterials. The surface topography of the biomaterial-based scaffold can modulate the proliferation and differentiation of MSCs. Presently, the development of micro- and nano-fabrication techniques has made it possible to control the surface topography of the scaffold precisely. In this review, we highlight and discuss how the main topographical features (i.e., roughness, patterns, and porosity) are an efficient approach to control the fate of MSCs and the application of topography in tissue engineering.https://www.mdpi.com/2079-4991/10/10/2070biomaterialsdifferentiationmesenchymal stem cellsscaffoldstissue engineeringtopography |
| spellingShingle | Xingli Cun Leticia Hosta-Rigau Topography: A Biophysical Approach to Direct the Fate of Mesenchymal Stem Cells in Tissue Engineering Applications Nanomaterials biomaterials differentiation mesenchymal stem cells scaffolds tissue engineering topography |
| title | Topography: A Biophysical Approach to Direct the Fate of Mesenchymal Stem Cells in Tissue Engineering Applications |
| title_full | Topography: A Biophysical Approach to Direct the Fate of Mesenchymal Stem Cells in Tissue Engineering Applications |
| title_fullStr | Topography: A Biophysical Approach to Direct the Fate of Mesenchymal Stem Cells in Tissue Engineering Applications |
| title_full_unstemmed | Topography: A Biophysical Approach to Direct the Fate of Mesenchymal Stem Cells in Tissue Engineering Applications |
| title_short | Topography: A Biophysical Approach to Direct the Fate of Mesenchymal Stem Cells in Tissue Engineering Applications |
| title_sort | topography a biophysical approach to direct the fate of mesenchymal stem cells in tissue engineering applications |
| topic | biomaterials differentiation mesenchymal stem cells scaffolds tissue engineering topography |
| url | https://www.mdpi.com/2079-4991/10/10/2070 |
| work_keys_str_mv | AT xinglicun topographyabiophysicalapproachtodirectthefateofmesenchymalstemcellsintissueengineeringapplications AT leticiahostarigau topographyabiophysicalapproachtodirectthefateofmesenchymalstemcellsintissueengineeringapplications |