Non-invasive differentiation of hepatic steatosis and steatohepatitis in a mouse model using nitroxyl radical as an MRI-contrast agent

Non-invasive differentiation of hepatic steatosis and steatohepatitis in a mouse model using nitroxyl radical as an MRI-contrast agent

Drug-induced steatohepatitis is considered more serious than drug-induced hepatic steatosis, so that differentiating between the two is crucial in drug development. In addition, early detection of drug-induced steatohepatitis is considered important since recovery is possible with drug withdrawal. H...

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Bibliographic Details
Main Authors: Yuka Yoshino, Yuta Fujii, Kazuhiro Chihara, Aya Nakae, Jun-ichiro Enmi, Yoshichika Yoshioka, Izuru Miyawaki
Format: Article
Language:English
Published: Elsevier 2024-06-01
Series:Toxicology Reports
Subjects:
Steatohepatitis
Magnetic resonance imaging
Nitroxyl radicals
Reactive oxygen species
Online Access:http://www.sciencedirect.com/science/article/pii/S2214750023001385

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