A comparative study of femtosecond pulsed laser ablation of meloxicam in distilled water and in air
Abstract The increasing prevalence of water insoluble or poorly soluble drugs calls for the development of new formulation methods. Common approaches include the reduction of particle size and degree of crystallinity. Pulsed laser ablation is a clean technique for producing sub-micrometre sized drug...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-06-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-36922-7 |
| _version_ | 1827916991240863744 |
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| author | Eszter Nagy Judit Kopniczky Tamás Smausz Máté Náfrádi Tünde Alapi János Bohus Viktor Pajer Piroska Szabó-Révész Rita Ambrus Béla Hopp |
| author_facet | Eszter Nagy Judit Kopniczky Tamás Smausz Máté Náfrádi Tünde Alapi János Bohus Viktor Pajer Piroska Szabó-Révész Rita Ambrus Béla Hopp |
| author_sort | Eszter Nagy |
| collection | DOAJ |
| description | Abstract The increasing prevalence of water insoluble or poorly soluble drugs calls for the development of new formulation methods. Common approaches include the reduction of particle size and degree of crystallinity. Pulsed laser ablation is a clean technique for producing sub-micrometre sized drug particles and has the potential to induce amorphization. We studied the effect of femtosecond pulsed laser ablation (ELI ALPS THz pump laser system: λc = 781 nm, τ = 135 fs) on meloxicam in distilled water and in air. The ablated particles were characterized chemically, morphologically and in terms of crystallinity. We demonstrated that femtosecond laser ablation can induce partial amorphization of the particles in addition to a reduction in particle size. In the case of femtosecond pulsed laser ablation in air, the formation of pure meloxicam spheres showed that this technique can produce amorphous meloxicam without the use of excipients, which is a unique result. We also aimed to describe the ablation processes in both investigated media. |
| first_indexed | 2024-03-13T03:22:37Z |
| format | Article |
| id | doaj.art-d3fec6c1e37d49f9889b064f7403575c |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-13T03:22:37Z |
| publishDate | 2023-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-d3fec6c1e37d49f9889b064f7403575c2023-06-25T11:15:29ZengNature PortfolioScientific Reports2045-23222023-06-0113111210.1038/s41598-023-36922-7A comparative study of femtosecond pulsed laser ablation of meloxicam in distilled water and in airEszter Nagy0Judit Kopniczky1Tamás Smausz2Máté Náfrádi3Tünde Alapi4János Bohus5Viktor Pajer6Piroska Szabó-Révész7Rita Ambrus8Béla Hopp9Department of Optics and Quantum Electronics, University of SzegedDepartment of Optics and Quantum Electronics, University of SzegedDepartment of Optics and Quantum Electronics, University of SzegedDepartment of Inorganic and Analytical Chemistry, University of SzegedDepartment of Inorganic and Analytical Chemistry, University of SzegedELI ALPS, ELI-HU Non-Profit Ltd.ELI ALPS, ELI-HU Non-Profit Ltd.Institute of Pharmaceutical Technology and Regulatory Affairs, University of SzegedInstitute of Pharmaceutical Technology and Regulatory Affairs, University of SzegedDepartment of Optics and Quantum Electronics, University of SzegedAbstract The increasing prevalence of water insoluble or poorly soluble drugs calls for the development of new formulation methods. Common approaches include the reduction of particle size and degree of crystallinity. Pulsed laser ablation is a clean technique for producing sub-micrometre sized drug particles and has the potential to induce amorphization. We studied the effect of femtosecond pulsed laser ablation (ELI ALPS THz pump laser system: λc = 781 nm, τ = 135 fs) on meloxicam in distilled water and in air. The ablated particles were characterized chemically, morphologically and in terms of crystallinity. We demonstrated that femtosecond laser ablation can induce partial amorphization of the particles in addition to a reduction in particle size. In the case of femtosecond pulsed laser ablation in air, the formation of pure meloxicam spheres showed that this technique can produce amorphous meloxicam without the use of excipients, which is a unique result. We also aimed to describe the ablation processes in both investigated media.https://doi.org/10.1038/s41598-023-36922-7 |
| spellingShingle | Eszter Nagy Judit Kopniczky Tamás Smausz Máté Náfrádi Tünde Alapi János Bohus Viktor Pajer Piroska Szabó-Révész Rita Ambrus Béla Hopp A comparative study of femtosecond pulsed laser ablation of meloxicam in distilled water and in air Scientific Reports |
| title | A comparative study of femtosecond pulsed laser ablation of meloxicam in distilled water and in air |
| title_full | A comparative study of femtosecond pulsed laser ablation of meloxicam in distilled water and in air |
| title_fullStr | A comparative study of femtosecond pulsed laser ablation of meloxicam in distilled water and in air |
| title_full_unstemmed | A comparative study of femtosecond pulsed laser ablation of meloxicam in distilled water and in air |
| title_short | A comparative study of femtosecond pulsed laser ablation of meloxicam in distilled water and in air |
| title_sort | comparative study of femtosecond pulsed laser ablation of meloxicam in distilled water and in air |
| url | https://doi.org/10.1038/s41598-023-36922-7 |
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