The Legacy of Sickness Behaviors
Systemic infections of all types lead to a syndrome known as sickness behaviors. Changes in the behavior of febrile humans and animals formed the original basis for this concept. Body temperature is behaviorally regulated in both endotherms and ectotherms. However, infections cause other changes in...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-12-01
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| Series: | Frontiers in Psychiatry |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2020.607269/full |
| _version_ | 1819171523977543680 |
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| author | Keith W. Kelley Keith W. Kelley Keith W. Kelley Stephen Kent Stephen Kent |
| author_facet | Keith W. Kelley Keith W. Kelley Keith W. Kelley Stephen Kent Stephen Kent |
| author_sort | Keith W. Kelley |
| collection | DOAJ |
| description | Systemic infections of all types lead to a syndrome known as sickness behaviors. Changes in the behavior of febrile humans and animals formed the original basis for this concept. Body temperature is behaviorally regulated in both endotherms and ectotherms. However, infections cause other changes in body functions, including sleep disruption, anorexia, cognitive and memory deficits and disorientation. The brain mediates this entire cluster of symptoms, even though most major infections occur outside the brain. The true importance of sickness behaviors is not the numerous discoveries of symptoms that affect all of us when we get sick. Instead, the legacy of 30 years of research in sickness behaviors is that it established the physiologic importance of reciprocal communication systems between the immune system and the brain. This conceptual advance remains in its infancy. |
| first_indexed | 2024-12-22T19:52:39Z |
| format | Article |
| id | doaj.art-d3ffd5c1d69d440b8cefa1a2c11748f0 |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-12-22T19:52:39Z |
| publishDate | 2020-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-d3ffd5c1d69d440b8cefa1a2c11748f02022-12-21T18:14:30ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402020-12-011110.3389/fpsyt.2020.607269607269The Legacy of Sickness BehaviorsKeith W. Kelley0Keith W. Kelley1Keith W. Kelley2Stephen Kent3Stephen Kent4Department of Pathology, College of Medicine, Urbana, IL, United StatesDepartment of Animal Sciences, College of Agricultural, Consumer & Environmental Sciences (ACES), University of Illinois at Urbana-Champaign, Urbana, IL, United StatesSchool of Psychology and Public Health, University of Illinois in Urbana-Champaign, Urbana, IL, United StatesSchool of Psychology and Public Health, La Trobe University, Melbourne, VIC, AustraliaDean and Head of School of Psychology & Public Health, Melbourne, VIC, AustraliaSystemic infections of all types lead to a syndrome known as sickness behaviors. Changes in the behavior of febrile humans and animals formed the original basis for this concept. Body temperature is behaviorally regulated in both endotherms and ectotherms. However, infections cause other changes in body functions, including sleep disruption, anorexia, cognitive and memory deficits and disorientation. The brain mediates this entire cluster of symptoms, even though most major infections occur outside the brain. The true importance of sickness behaviors is not the numerous discoveries of symptoms that affect all of us when we get sick. Instead, the legacy of 30 years of research in sickness behaviors is that it established the physiologic importance of reciprocal communication systems between the immune system and the brain. This conceptual advance remains in its infancy.https://www.frontiersin.org/articles/10.3389/fpsyt.2020.607269/fullimmune-brain communicationfeversystemic physiologyinterleukin-1motivated behaviors |
| spellingShingle | Keith W. Kelley Keith W. Kelley Keith W. Kelley Stephen Kent Stephen Kent The Legacy of Sickness Behaviors Frontiers in Psychiatry immune-brain communication fever systemic physiology interleukin-1 motivated behaviors |
| title | The Legacy of Sickness Behaviors |
| title_full | The Legacy of Sickness Behaviors |
| title_fullStr | The Legacy of Sickness Behaviors |
| title_full_unstemmed | The Legacy of Sickness Behaviors |
| title_short | The Legacy of Sickness Behaviors |
| title_sort | legacy of sickness behaviors |
| topic | immune-brain communication fever systemic physiology interleukin-1 motivated behaviors |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2020.607269/full |
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