GAP-43 and BASP1 in Axon Regeneration: Implications for the Treatment of Neurodegenerative Diseases
Growth-associated protein-43 (GAP-43) and brain acid-soluble protein 1 (BASP1) regulate actin dynamics and presynaptic vesicle cycling at axon terminals, thereby facilitating axonal growth, regeneration, and plasticity. These functions highly depend on changes in GAP-43 and BASP1 expression levels a...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-09-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fcell.2020.567537/full |
| _version_ | 1831653928318533632 |
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| author | Daayun Chung Andrew Shum Gabriela Caraveo |
| author_facet | Daayun Chung Andrew Shum Gabriela Caraveo |
| author_sort | Daayun Chung |
| collection | DOAJ |
| description | Growth-associated protein-43 (GAP-43) and brain acid-soluble protein 1 (BASP1) regulate actin dynamics and presynaptic vesicle cycling at axon terminals, thereby facilitating axonal growth, regeneration, and plasticity. These functions highly depend on changes in GAP-43 and BASP1 expression levels and post-translational modifications such as phosphorylation. Interestingly, examinations of GAP-43 and BASP1 in neurodegenerative diseases reveal alterations in their expression and phosphorylation profiles. This review provides an overview of the structural properties, regulations, and functions of GAP-43 and BASP1, highlighting their involvement in neural injury response and regeneration. By discussing GAP-43 and BASP1 in the context of neurodegenerative diseases, we also explore the therapeutic potential of modulating their activities to compensate for neuron loss in neurodegenerative diseases. |
| first_indexed | 2024-12-19T16:18:00Z |
| format | Article |
| id | doaj.art-d4000396b6d246b98522186074906049 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-19T16:18:00Z |
| publishDate | 2020-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-d4000396b6d246b985221860749060492022-12-21T20:14:34ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2020-09-01810.3389/fcell.2020.567537567537GAP-43 and BASP1 in Axon Regeneration: Implications for the Treatment of Neurodegenerative DiseasesDaayun ChungAndrew ShumGabriela CaraveoGrowth-associated protein-43 (GAP-43) and brain acid-soluble protein 1 (BASP1) regulate actin dynamics and presynaptic vesicle cycling at axon terminals, thereby facilitating axonal growth, regeneration, and plasticity. These functions highly depend on changes in GAP-43 and BASP1 expression levels and post-translational modifications such as phosphorylation. Interestingly, examinations of GAP-43 and BASP1 in neurodegenerative diseases reveal alterations in their expression and phosphorylation profiles. This review provides an overview of the structural properties, regulations, and functions of GAP-43 and BASP1, highlighting their involvement in neural injury response and regeneration. By discussing GAP-43 and BASP1 in the context of neurodegenerative diseases, we also explore the therapeutic potential of modulating their activities to compensate for neuron loss in neurodegenerative diseases.https://www.frontiersin.org/article/10.3389/fcell.2020.567537/fullGAP-43BASP1phosphorylationneural injury responseaxon regenerationneurodegenerative diseases |
| spellingShingle | Daayun Chung Andrew Shum Gabriela Caraveo GAP-43 and BASP1 in Axon Regeneration: Implications for the Treatment of Neurodegenerative Diseases Frontiers in Cell and Developmental Biology GAP-43 BASP1 phosphorylation neural injury response axon regeneration neurodegenerative diseases |
| title | GAP-43 and BASP1 in Axon Regeneration: Implications for the Treatment of Neurodegenerative Diseases |
| title_full | GAP-43 and BASP1 in Axon Regeneration: Implications for the Treatment of Neurodegenerative Diseases |
| title_fullStr | GAP-43 and BASP1 in Axon Regeneration: Implications for the Treatment of Neurodegenerative Diseases |
| title_full_unstemmed | GAP-43 and BASP1 in Axon Regeneration: Implications for the Treatment of Neurodegenerative Diseases |
| title_short | GAP-43 and BASP1 in Axon Regeneration: Implications for the Treatment of Neurodegenerative Diseases |
| title_sort | gap 43 and basp1 in axon regeneration implications for the treatment of neurodegenerative diseases |
| topic | GAP-43 BASP1 phosphorylation neural injury response axon regeneration neurodegenerative diseases |
| url | https://www.frontiersin.org/article/10.3389/fcell.2020.567537/full |
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