Spread of genetically similar noroviruses in Bangkok, Thailand, through symptomatic and asymptomatic individuals
Norovirus infection is a major cause of acute gastroenteritis, although some infected individuals are asymptomatic. GII.4 is the predominant genotype worldwide and, since 2000, has been the most prevalent in patients in Thailand with acute gastroenteritis. We screened stool samples for norovirus in...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-10-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844021023537 |
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| author | Patcharaporn Boonyos Michittra Boonchan Benjarat Phattanawiboon Nutthawan Nonthabenjawan Ratana Tacharoenmuang Ratigorn Gunpapong Phakapun Singchai Sompong Upchai Pimpha Rungnobhakhun Jutarat Mekmullica Worakarn Towayunanta Kobkool Chuntrakool Karn Ngaopravet Kriangsak Ruchusatsawat Somchai Sangkitporn Ballang Uppapong Eisuke Mekada Yoshiharu Matsuura Masashi Tatsumi Hiroto Mizushima |
| author_facet | Patcharaporn Boonyos Michittra Boonchan Benjarat Phattanawiboon Nutthawan Nonthabenjawan Ratana Tacharoenmuang Ratigorn Gunpapong Phakapun Singchai Sompong Upchai Pimpha Rungnobhakhun Jutarat Mekmullica Worakarn Towayunanta Kobkool Chuntrakool Karn Ngaopravet Kriangsak Ruchusatsawat Somchai Sangkitporn Ballang Uppapong Eisuke Mekada Yoshiharu Matsuura Masashi Tatsumi Hiroto Mizushima |
| author_sort | Patcharaporn Boonyos |
| collection | DOAJ |
| description | Norovirus infection is a major cause of acute gastroenteritis, although some infected individuals are asymptomatic. GII.4 is the predominant genotype worldwide and, since 2000, has been the most prevalent in patients in Thailand with acute gastroenteritis. We screened stool samples for norovirus in 786 patients with acute gastroenteritis who were admitted to a hospital in Bangkok from 2017 to early 2019 and detected it in 136 specimens (17.3%). Eight and 124 specimens were positive for the GI and GII genogroups, respectively, and the remaining 4 specimens were double-positive. Nine genotypes (GI.3, GI.5, GII.2, GII.3, GII.4, GII.6, GII.8, GII.13, and GII.17) were identified from 140 strains, and 72 strains (51.4%) were GII.4. We had previously conducted a one-year survey of norovirus infection in residents of a community in Bangkok from May 2018 to April 2019 and found that a substantial portion of the residents were infected asymptomatically. The 9 genotypes identified in the patients were also commonly identified in the community residents. To investigate the relationship between noroviruses identified in the acute gastroenteritis patients and those identified in the community residents, phylogenetic tree analysis was conducted. Of the 9 genotypes, 8 showed similarities in both their genomic sequences and their deduced amino acid sequences. In addition, strain replacement of GI.3 was observed in both the patients and the community residents within the overlapping period. These results suggested that norovirus spreads efficiently to the community by simultaneously causing symptomatic and asymptomatic infections. |
| first_indexed | 2024-12-21T00:52:32Z |
| format | Article |
| id | doaj.art-d400559bc998452f869267dceaf335d3 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-12-21T00:52:32Z |
| publishDate | 2021-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-d400559bc998452f869267dceaf335d32022-12-21T19:21:22ZengElsevierHeliyon2405-84402021-10-01710e08250Spread of genetically similar noroviruses in Bangkok, Thailand, through symptomatic and asymptomatic individualsPatcharaporn Boonyos0Michittra Boonchan1Benjarat Phattanawiboon2Nutthawan Nonthabenjawan3Ratana Tacharoenmuang4Ratigorn Gunpapong5Phakapun Singchai6Sompong Upchai7Pimpha Rungnobhakhun8Jutarat Mekmullica9Worakarn Towayunanta10Kobkool Chuntrakool11Karn Ngaopravet12Kriangsak Ruchusatsawat13Somchai Sangkitporn14Ballang Uppapong15Eisuke Mekada16Yoshiharu Matsuura17Masashi Tatsumi18Hiroto Mizushima19Thailand−Japan Research Collaboration Center on Emerging and Re-emerging Infections, Nonthaburi, ThailandThailand−Japan Research Collaboration Center on Emerging and Re-emerging Infections, Nonthaburi, ThailandThailand−Japan Research Collaboration Center on Emerging and Re-emerging Infections, Nonthaburi, ThailandThailand−Japan Research Collaboration Center on Emerging and Re-emerging Infections, Nonthaburi, ThailandNational Institute of Health, Department of Medical Sciences, Ministry of Public Health, Nonthaburi, ThailandNational Institute of Health, Department of Medical Sciences, Ministry of Public Health, Nonthaburi, ThailandNational Institute of Health, Department of Medical Sciences, Ministry of Public Health, Nonthaburi, ThailandNational Institute of Health, Department of Medical Sciences, Ministry of Public Health, Nonthaburi, ThailandBhumibol Adulyadej Hospital, Bangkok, ThailandBhumibol Adulyadej Hospital, Bangkok, ThailandPublic Health Center 41, Bangkok, ThailandPublic Health Center 41, Bangkok, ThailandPublic Health Center 41, Bangkok, ThailandNational Institute of Health, Department of Medical Sciences, Ministry of Public Health, Nonthaburi, ThailandNational Institute of Health, Department of Medical Sciences, Ministry of Public Health, Nonthaburi, ThailandNational Institute of Health, Department of Medical Sciences, Ministry of Public Health, Nonthaburi, ThailandResearch and Education Promotion Foundation, Bangkok, ThailandResearch Institute for Microbial Diseases, Osaka University, Osaka, JapanThailand−Japan Research Collaboration Center on Emerging and Re-emerging Infections, Nonthaburi, ThailandThailand−Japan Research Collaboration Center on Emerging and Re-emerging Infections, Nonthaburi, Thailand; Corresponding author.Norovirus infection is a major cause of acute gastroenteritis, although some infected individuals are asymptomatic. GII.4 is the predominant genotype worldwide and, since 2000, has been the most prevalent in patients in Thailand with acute gastroenteritis. We screened stool samples for norovirus in 786 patients with acute gastroenteritis who were admitted to a hospital in Bangkok from 2017 to early 2019 and detected it in 136 specimens (17.3%). Eight and 124 specimens were positive for the GI and GII genogroups, respectively, and the remaining 4 specimens were double-positive. Nine genotypes (GI.3, GI.5, GII.2, GII.3, GII.4, GII.6, GII.8, GII.13, and GII.17) were identified from 140 strains, and 72 strains (51.4%) were GII.4. We had previously conducted a one-year survey of norovirus infection in residents of a community in Bangkok from May 2018 to April 2019 and found that a substantial portion of the residents were infected asymptomatically. The 9 genotypes identified in the patients were also commonly identified in the community residents. To investigate the relationship between noroviruses identified in the acute gastroenteritis patients and those identified in the community residents, phylogenetic tree analysis was conducted. Of the 9 genotypes, 8 showed similarities in both their genomic sequences and their deduced amino acid sequences. In addition, strain replacement of GI.3 was observed in both the patients and the community residents within the overlapping period. These results suggested that norovirus spreads efficiently to the community by simultaneously causing symptomatic and asymptomatic infections.http://www.sciencedirect.com/science/article/pii/S2405844021023537NorovirusSymptomatic infectionAsymptomatic infection |
| spellingShingle | Patcharaporn Boonyos Michittra Boonchan Benjarat Phattanawiboon Nutthawan Nonthabenjawan Ratana Tacharoenmuang Ratigorn Gunpapong Phakapun Singchai Sompong Upchai Pimpha Rungnobhakhun Jutarat Mekmullica Worakarn Towayunanta Kobkool Chuntrakool Karn Ngaopravet Kriangsak Ruchusatsawat Somchai Sangkitporn Ballang Uppapong Eisuke Mekada Yoshiharu Matsuura Masashi Tatsumi Hiroto Mizushima Spread of genetically similar noroviruses in Bangkok, Thailand, through symptomatic and asymptomatic individuals Heliyon Norovirus Symptomatic infection Asymptomatic infection |
| title | Spread of genetically similar noroviruses in Bangkok, Thailand, through symptomatic and asymptomatic individuals |
| title_full | Spread of genetically similar noroviruses in Bangkok, Thailand, through symptomatic and asymptomatic individuals |
| title_fullStr | Spread of genetically similar noroviruses in Bangkok, Thailand, through symptomatic and asymptomatic individuals |
| title_full_unstemmed | Spread of genetically similar noroviruses in Bangkok, Thailand, through symptomatic and asymptomatic individuals |
| title_short | Spread of genetically similar noroviruses in Bangkok, Thailand, through symptomatic and asymptomatic individuals |
| title_sort | spread of genetically similar noroviruses in bangkok thailand through symptomatic and asymptomatic individuals |
| topic | Norovirus Symptomatic infection Asymptomatic infection |
| url | http://www.sciencedirect.com/science/article/pii/S2405844021023537 |
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