Heritabilities of Facial Measurements and Their Latent Factors in Korean Families
Genetic studies on facial morphology targeting healthy populations are fundamental in understanding the specific genetic influences involved; yet, most studies to date, if not all, have been focused on congenital diseases accompanied by facial anomalies. To study the specific genetic cues determinin...
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| Format: | Article |
| Language: | English |
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Korea Genome Organization
2013-06-01
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| Series: | Genomics & Informatics |
| Subjects: | |
| Online Access: | http://genominfo.org/upload/pdf/gni-11-83.pdf |
| _version_ | 1818445794561228800 |
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| author | Hyun-Jin Kim Sun-Wha Im Ganchimeg Jargal Siwoo Lee Jae-Hyuk Yi Jeong-Yeon Park Joohon Sung Sung-Il Cho Jong-Yeol Kim Jong-Il Kim Jeong-Sun Seo |
| author_facet | Hyun-Jin Kim Sun-Wha Im Ganchimeg Jargal Siwoo Lee Jae-Hyuk Yi Jeong-Yeon Park Joohon Sung Sung-Il Cho Jong-Yeol Kim Jong-Il Kim Jeong-Sun Seo |
| author_sort | Hyun-Jin Kim |
| collection | DOAJ |
| description | Genetic studies on facial morphology targeting healthy populations are fundamental in understanding the specific genetic influences involved; yet, most studies to date, if not all, have been focused on congenital diseases accompanied by facial anomalies. To study the specific genetic cues determining facial morphology, we estimated familial correlations and heritabilities of 14 facial measurements and 3 latent factors inferred from a factor analysis in a subset of the Korean population. The study included a total of 229 individuals from 38 families. We evaluated a total of 14 facial measurements using 2D digital photographs. We performed factor analysis to infer common latent variables. The heritabilities of 13 facial measurements were statistically significant (p < 0.05) and ranged from 0.25 to 0.61. Of these, the heritability of intercanthal width in the orbital region was found to be the highest (h2 = 0.61, SE = 0.14). Three factors (lower face portion, orbital region, and vertical length) were obtained through factor analysis, where the heritability values ranged from 0.45 to 0.55. The heritability values for each factor were higher than the mean heritability value of individual original measurements. We have confirmed the genetic influence on facial anthropometric traits and suggest a potential way to categorize and analyze the facial portions into different groups. |
| first_indexed | 2024-12-14T19:37:30Z |
| format | Article |
| id | doaj.art-d401b532b7e94429830c8ad51c9862e6 |
| institution | Directory Open Access Journal |
| issn | 1598-866X 2234-0742 |
| language | English |
| last_indexed | 2024-12-14T19:37:30Z |
| publishDate | 2013-06-01 |
| publisher | Korea Genome Organization |
| record_format | Article |
| series | Genomics & Informatics |
| spelling | doaj.art-d401b532b7e94429830c8ad51c9862e62022-12-21T22:49:50ZengKorea Genome OrganizationGenomics & Informatics1598-866X2234-07422013-06-01112839210.5808/GI.2013.11.2.8384Heritabilities of Facial Measurements and Their Latent Factors in Korean FamiliesHyun-Jin Kim0Sun-Wha Im1Ganchimeg Jargal2Siwoo Lee3Jae-Hyuk Yi4Jeong-Yeon Park5Joohon Sung6Sung-Il Cho7Jong-Yeol Kim8Jong-Il Kim9Jeong-Sun Seo10Genomic Medicine Institute, Medical Research Center, Seoul National University, Seoul 110-799, Korea.Genomic Medicine Institute, Medical Research Center, Seoul National University, Seoul 110-799, Korea.Psoma Therapeutics, Seoul 153-781, Korea.Department of Epidemiology, Graduate School of Public Health and Institute of Health and Environment, Seoul National University, Seoul 151-742, Korea.Genomic Medicine Institute, Medical Research Center, Seoul National University, Seoul 110-799, Korea.Department of Biochemistry and Molecular Biology, Seoul National University College of Medicine, Seoul 110-799, Korea.Psoma Therapeutics, Seoul 153-781, Korea.Psoma Therapeutics, Seoul 153-781, Korea.Department of Epidemiology, Graduate School of Public Health and Institute of Health and Environment, Seoul National University, Seoul 151-742, Korea.Genomic Medicine Institute, Medical Research Center, Seoul National University, Seoul 110-799, Korea.Genomic Medicine Institute, Medical Research Center, Seoul National University, Seoul 110-799, Korea.Genetic studies on facial morphology targeting healthy populations are fundamental in understanding the specific genetic influences involved; yet, most studies to date, if not all, have been focused on congenital diseases accompanied by facial anomalies. To study the specific genetic cues determining facial morphology, we estimated familial correlations and heritabilities of 14 facial measurements and 3 latent factors inferred from a factor analysis in a subset of the Korean population. The study included a total of 229 individuals from 38 families. We evaluated a total of 14 facial measurements using 2D digital photographs. We performed factor analysis to infer common latent variables. The heritabilities of 13 facial measurements were statistically significant (p < 0.05) and ranged from 0.25 to 0.61. Of these, the heritability of intercanthal width in the orbital region was found to be the highest (h2 = 0.61, SE = 0.14). Three factors (lower face portion, orbital region, and vertical length) were obtained through factor analysis, where the heritability values ranged from 0.45 to 0.55. The heritability values for each factor were higher than the mean heritability value of individual original measurements. We have confirmed the genetic influence on facial anthropometric traits and suggest a potential way to categorize and analyze the facial portions into different groups.http://genominfo.org/upload/pdf/gni-11-83.pdffacial bonesgenetic researchstatistical factor analysis |
| spellingShingle | Hyun-Jin Kim Sun-Wha Im Ganchimeg Jargal Siwoo Lee Jae-Hyuk Yi Jeong-Yeon Park Joohon Sung Sung-Il Cho Jong-Yeol Kim Jong-Il Kim Jeong-Sun Seo Heritabilities of Facial Measurements and Their Latent Factors in Korean Families Genomics & Informatics facial bones genetic research statistical factor analysis |
| title | Heritabilities of Facial Measurements and Their Latent Factors in Korean Families |
| title_full | Heritabilities of Facial Measurements and Their Latent Factors in Korean Families |
| title_fullStr | Heritabilities of Facial Measurements and Their Latent Factors in Korean Families |
| title_full_unstemmed | Heritabilities of Facial Measurements and Their Latent Factors in Korean Families |
| title_short | Heritabilities of Facial Measurements and Their Latent Factors in Korean Families |
| title_sort | heritabilities of facial measurements and their latent factors in korean families |
| topic | facial bones genetic research statistical factor analysis |
| url | http://genominfo.org/upload/pdf/gni-11-83.pdf |
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