Metabolic heterogeneity in TNBCs: A potential determinant of therapeutic efficacy of 2-deoxyglucose and metformin combinatory therapy

Metabolic heterogeneity in TNBCs: A potential determinant of therapeutic efficacy of 2-deoxyglucose and metformin combinatory therapy

Breast cancers (BCs) remain the leading cause of cancer-related deaths among women worldwide. Among the different types of BCs, treating the highly aggressive, invasive, and metastatic triple-negative BCs (TNBCs) that do not respond to hormonal/human epidermal growth factor receptor 2 (HER2) targete...

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Bibliographic Details
Main Authors: Samson Mathews Samuel, Elizabeth Varghese, Noothan Jyothi Satheesh, Chris R. Triggle, Dietrich Büsselberg
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Cancer
Diabetes
Hyperglycemia
Metformin
Triple negative breast cancers (TNBCs)
Tumor metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223007011

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