Electrospun Nanofibers Revisited: An Update on the Emerging Applications in Nanomedicine
Electrospinning (ES) has become a straightforward and customizable drug delivery technique for fabricating drug-loaded nanofibers (NFs) using various biodegradable and non-biodegradable polymers. One of NF’s pros is to provide a controlled drug release through managing the NF structure by changing t...
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| Format: | Article |
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MDPI AG
2022-03-01
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| Series: | Materials |
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| Online Access: | https://www.mdpi.com/1996-1944/15/5/1934 |
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| author | Nehal E. Elsadek Abdalrazeq Nagah Tarek M. Ibrahim Hitesh Chopra Ghada A. Ghonaim Sherif E. Emam Simona Cavalu Mohamed S. Attia |
| author_facet | Nehal E. Elsadek Abdalrazeq Nagah Tarek M. Ibrahim Hitesh Chopra Ghada A. Ghonaim Sherif E. Emam Simona Cavalu Mohamed S. Attia |
| author_sort | Nehal E. Elsadek |
| collection | DOAJ |
| description | Electrospinning (ES) has become a straightforward and customizable drug delivery technique for fabricating drug-loaded nanofibers (NFs) using various biodegradable and non-biodegradable polymers. One of NF’s pros is to provide a controlled drug release through managing the NF structure by changing the spinneret type and nature of the used polymer. Electrospun NFs are employed as implants in several applications including, cancer therapy, microbial infections, and regenerative medicine. These implants facilitate a unique local delivery of chemotherapy because of their high loading capability, wide surface area, and cost-effectiveness. Multi-drug combination, magnetic, thermal, and gene therapies are promising strategies for improving chemotherapeutic efficiency. In addition, implants are recognized as an effective antimicrobial drug delivery system overriding drawbacks of traditional antibiotic administration routes such as their bioavailability and dosage levels. Recently, a sophisticated strategy has emerged for wound healing by producing biomimetic nanofibrous materials with clinically relevant properties and desirable loading capability with regenerative agents. Electrospun NFs have proposed unique solutions, including pelvic organ prolapse treatment, viable alternatives to surgical operations, and dental tissue regeneration. Conventional ES setups include difficult-assembled mega-sized equipment producing bulky matrices with inadequate stability and storage. Lately, there has become an increasing need for portable ES devices using completely available off-shelf materials to yield highly-efficient NFs for dressing wounds and rapid hemostasis. This review covers recent updates on electrospun NFs in nanomedicine applications. ES of biopolymers and drugs is discussed regarding their current scope and future outlook. |
| first_indexed | 2024-03-09T20:32:30Z |
| format | Article |
| id | doaj.art-d403b177ef1c46b599516bfdbab731e6 |
| institution | Directory Open Access Journal |
| issn | 1996-1944 |
| language | English |
| last_indexed | 2024-03-09T20:32:30Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Materials |
| spelling | doaj.art-d403b177ef1c46b599516bfdbab731e62023-11-23T23:21:07ZengMDPI AGMaterials1996-19442022-03-01155193410.3390/ma15051934Electrospun Nanofibers Revisited: An Update on the Emerging Applications in NanomedicineNehal E. Elsadek0Abdalrazeq Nagah1Tarek M. Ibrahim2Hitesh Chopra3Ghada A. Ghonaim4Sherif E. Emam5Simona Cavalu6Mohamed S. Attia7Department of Pharmacokinetics and Biopharmaceutics, Institute of Biomedical Sciences, Tokushima University, 1-78-1 Sho-machi, Tokushima 770-8505, JapanFaculty of Pharmacy, Zagazig University, Zagazig 44519, EgyptDepartment of Pharmaceutics, Faculty of Pharmacy, Zagazig University, Zagazig 44519, EgyptChitkara College of Pharmacy, Chitkara University, Punjab 140401, IndiaFaculty of Pharmacy, Zagazig University, Zagazig 44519, EgyptDepartment of Pharmaceutics, Faculty of Pharmacy, Zagazig University, Zagazig 44519, EgyptFaculty of Medicine and Pharmacy, University of Oradea, P-ta 1 Decembrie 10, 410087 Oradea, RomaniaDepartment of Pharmaceutics, Faculty of Pharmacy, Zagazig University, Zagazig 44519, EgyptElectrospinning (ES) has become a straightforward and customizable drug delivery technique for fabricating drug-loaded nanofibers (NFs) using various biodegradable and non-biodegradable polymers. One of NF’s pros is to provide a controlled drug release through managing the NF structure by changing the spinneret type and nature of the used polymer. Electrospun NFs are employed as implants in several applications including, cancer therapy, microbial infections, and regenerative medicine. These implants facilitate a unique local delivery of chemotherapy because of their high loading capability, wide surface area, and cost-effectiveness. Multi-drug combination, magnetic, thermal, and gene therapies are promising strategies for improving chemotherapeutic efficiency. In addition, implants are recognized as an effective antimicrobial drug delivery system overriding drawbacks of traditional antibiotic administration routes such as their bioavailability and dosage levels. Recently, a sophisticated strategy has emerged for wound healing by producing biomimetic nanofibrous materials with clinically relevant properties and desirable loading capability with regenerative agents. Electrospun NFs have proposed unique solutions, including pelvic organ prolapse treatment, viable alternatives to surgical operations, and dental tissue regeneration. Conventional ES setups include difficult-assembled mega-sized equipment producing bulky matrices with inadequate stability and storage. Lately, there has become an increasing need for portable ES devices using completely available off-shelf materials to yield highly-efficient NFs for dressing wounds and rapid hemostasis. This review covers recent updates on electrospun NFs in nanomedicine applications. ES of biopolymers and drugs is discussed regarding their current scope and future outlook.https://www.mdpi.com/1996-1944/15/5/1934electrospinningnanofibersimplantswound healingnanomedicinetargeted delivery |
| spellingShingle | Nehal E. Elsadek Abdalrazeq Nagah Tarek M. Ibrahim Hitesh Chopra Ghada A. Ghonaim Sherif E. Emam Simona Cavalu Mohamed S. Attia Electrospun Nanofibers Revisited: An Update on the Emerging Applications in Nanomedicine Materials electrospinning nanofibers implants wound healing nanomedicine targeted delivery |
| title | Electrospun Nanofibers Revisited: An Update on the Emerging Applications in Nanomedicine |
| title_full | Electrospun Nanofibers Revisited: An Update on the Emerging Applications in Nanomedicine |
| title_fullStr | Electrospun Nanofibers Revisited: An Update on the Emerging Applications in Nanomedicine |
| title_full_unstemmed | Electrospun Nanofibers Revisited: An Update on the Emerging Applications in Nanomedicine |
| title_short | Electrospun Nanofibers Revisited: An Update on the Emerging Applications in Nanomedicine |
| title_sort | electrospun nanofibers revisited an update on the emerging applications in nanomedicine |
| topic | electrospinning nanofibers implants wound healing nanomedicine targeted delivery |
| url | https://www.mdpi.com/1996-1944/15/5/1934 |
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