Mortality and Morbidity of Extremely Low Birth Weight Infants in the Mainland of China: A Multi-center Study
Background: With the progress of perinatal medicine and neonatal technology, more and more extremely low birth weight (ELBW) survived all over the world. This study was designed to investigate the short-term outcomes of ELBW infants during their Neonatal Intensive Care Unit (NICU) stay in the mainla...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer
2015-01-01
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| Series: | Chinese Medical Journal |
| Subjects: | |
| Online Access: | http://www.cmj.org/article.asp?issn=0366-6999;year=2015;volume=128;issue=20;spage=2743;epage=2750;aulast=Lin |
| _version_ | 1828528144543383552 |
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| author | Hui-Jia Lin Li-Zhong Du Xiao-Lu Ma Li-Ping Shi Jia-Hua Pan Xiao-Mei Tong Qiu-Ping Li Jian-Guo Zhou Bing Yi Ling Liu Yun-Bing Chen Qiu-Fen Wei Hui-Qing Wu Mei Li Cui-Qing Liu Xi-Rong Gao Shi-Wen Xia Wen-Bin Li Chao-Ying Yan Ling He Kun Liang Xiao-Yu Zhou Shu-Ping Han Qin Lyu Yin-Ping Qiu Wen Li Dong-Mei Chen Hong-Ru Lu Xiao-Hong Liu Hong Liu Zhen-Lang Lin Li Liu Jia-Jun Zhu Hong Xiong Shao-Jie Yue Si-Qi Zhuang |
| author_facet | Hui-Jia Lin Li-Zhong Du Xiao-Lu Ma Li-Ping Shi Jia-Hua Pan Xiao-Mei Tong Qiu-Ping Li Jian-Guo Zhou Bing Yi Ling Liu Yun-Bing Chen Qiu-Fen Wei Hui-Qing Wu Mei Li Cui-Qing Liu Xi-Rong Gao Shi-Wen Xia Wen-Bin Li Chao-Ying Yan Ling He Kun Liang Xiao-Yu Zhou Shu-Ping Han Qin Lyu Yin-Ping Qiu Wen Li Dong-Mei Chen Hong-Ru Lu Xiao-Hong Liu Hong Liu Zhen-Lang Lin Li Liu Jia-Jun Zhu Hong Xiong Shao-Jie Yue Si-Qi Zhuang |
| author_sort | Hui-Jia Lin |
| collection | DOAJ |
| description | Background: With the progress of perinatal medicine and neonatal technology, more and more extremely low birth weight (ELBW) survived all over the world. This study was designed to investigate the short-term outcomes of ELBW infants during their Neonatal Intensive Care Unit (NICU) stay in the mainland of China.
Methods: All infants admitted to 26 NICUs with a birth weight (BW) < l000 g were included between January l, 2011 and December 31, 2011. All the data were collected retrospectively from clinical records by a prospectively designed questionnaire. The data collected from each NICU transmitted to the main institution where the results were aggregated and analyzed. Categorical variables were performed with Pearson Chi-square test. Binary Logistic regression analysis was used to detect risk factors.
Results: A total of 258 ELBW infants were admitted to 26 NICUs, of whom the mean gestational age (GA) was 28.1 ± 2.2 weeks, and the mean BW was 868 ± 97 g. The overall survival rate at discharge was 50.0%. Despite aggressive treatment 60 infants (23.3%) died and another 69 infants (26.7%) died after medical care withdrawal. Furthermore, the survival rate was significantly higher in coastal areas than inland areas (53.6% vs. 35.3%, P = 0.019). BW < 750 g and GA < 28 weeks were the largest risk factors, and being small for gestational age was a protective factor related to mortality. Respiratory distress syndrome was the most common complication. The incidence of patent ductus arteriosus, intraventricular hemorrhage, periventricular leukomalacia, bronchopulmonary dysplasia, retinopathy of prematurity was 26.2%, 33.7%, 6.7%, 48.1%, and 41.4%, respectively. Ventilator associated pneumonia was the most common hospital acquired infection during hospitalization.
Conclusions: Our study was the first survey that revealed the present status of ELBW infants in the mainland of China. The mortality and morbidity of ELBW infants remained high as compared to other developed countries. |
| first_indexed | 2024-12-11T21:48:14Z |
| format | Article |
| id | doaj.art-d40558bdcc92400f8000b6fa9f3a53a1 |
| institution | Directory Open Access Journal |
| issn | 0366-6999 |
| language | English |
| last_indexed | 2024-12-11T21:48:14Z |
| publishDate | 2015-01-01 |
| publisher | Wolters Kluwer |
| record_format | Article |
| series | Chinese Medical Journal |
| spelling | doaj.art-d40558bdcc92400f8000b6fa9f3a53a12022-12-22T00:49:33ZengWolters KluwerChinese Medical Journal0366-69992015-01-01128202743275010.4103/0366-6999.167312Mortality and Morbidity of Extremely Low Birth Weight Infants in the Mainland of China: A Multi-center StudyHui-Jia LinLi-Zhong DuXiao-Lu MaLi-Ping ShiJia-Hua PanXiao-Mei TongQiu-Ping LiJian-Guo ZhouBing YiLing LiuYun-Bing ChenQiu-Fen WeiHui-Qing WuMei LiCui-Qing LiuXi-Rong GaoShi-Wen XiaWen-Bin LiChao-Ying YanLing HeKun LiangXiao-Yu ZhouShu-Ping HanQin LyuYin-Ping QiuWen LiDong-Mei ChenHong-Ru LuXiao-Hong LiuHong LiuZhen-Lang LinLi LiuJia-Jun ZhuHong XiongShao-Jie YueSi-Qi ZhuangBackground: With the progress of perinatal medicine and neonatal technology, more and more extremely low birth weight (ELBW) survived all over the world. This study was designed to investigate the short-term outcomes of ELBW infants during their Neonatal Intensive Care Unit (NICU) stay in the mainland of China. Methods: All infants admitted to 26 NICUs with a birth weight (BW) < l000 g were included between January l, 2011 and December 31, 2011. All the data were collected retrospectively from clinical records by a prospectively designed questionnaire. The data collected from each NICU transmitted to the main institution where the results were aggregated and analyzed. Categorical variables were performed with Pearson Chi-square test. Binary Logistic regression analysis was used to detect risk factors. Results: A total of 258 ELBW infants were admitted to 26 NICUs, of whom the mean gestational age (GA) was 28.1 ± 2.2 weeks, and the mean BW was 868 ± 97 g. The overall survival rate at discharge was 50.0%. Despite aggressive treatment 60 infants (23.3%) died and another 69 infants (26.7%) died after medical care withdrawal. Furthermore, the survival rate was significantly higher in coastal areas than inland areas (53.6% vs. 35.3%, P = 0.019). BW < 750 g and GA < 28 weeks were the largest risk factors, and being small for gestational age was a protective factor related to mortality. Respiratory distress syndrome was the most common complication. The incidence of patent ductus arteriosus, intraventricular hemorrhage, periventricular leukomalacia, bronchopulmonary dysplasia, retinopathy of prematurity was 26.2%, 33.7%, 6.7%, 48.1%, and 41.4%, respectively. Ventilator associated pneumonia was the most common hospital acquired infection during hospitalization. Conclusions: Our study was the first survey that revealed the present status of ELBW infants in the mainland of China. The mortality and morbidity of ELBW infants remained high as compared to other developed countries.http://www.cmj.org/article.asp?issn=0366-6999;year=2015;volume=128;issue=20;spage=2743;epage=2750;aulast=LinExtremely Low Birth Weight; Infant; Mortality; National Survey |
| spellingShingle | Hui-Jia Lin Li-Zhong Du Xiao-Lu Ma Li-Ping Shi Jia-Hua Pan Xiao-Mei Tong Qiu-Ping Li Jian-Guo Zhou Bing Yi Ling Liu Yun-Bing Chen Qiu-Fen Wei Hui-Qing Wu Mei Li Cui-Qing Liu Xi-Rong Gao Shi-Wen Xia Wen-Bin Li Chao-Ying Yan Ling He Kun Liang Xiao-Yu Zhou Shu-Ping Han Qin Lyu Yin-Ping Qiu Wen Li Dong-Mei Chen Hong-Ru Lu Xiao-Hong Liu Hong Liu Zhen-Lang Lin Li Liu Jia-Jun Zhu Hong Xiong Shao-Jie Yue Si-Qi Zhuang Mortality and Morbidity of Extremely Low Birth Weight Infants in the Mainland of China: A Multi-center Study Chinese Medical Journal Extremely Low Birth Weight; Infant; Mortality; National Survey |
| title | Mortality and Morbidity of Extremely Low Birth Weight Infants in the Mainland of China: A Multi-center Study |
| title_full | Mortality and Morbidity of Extremely Low Birth Weight Infants in the Mainland of China: A Multi-center Study |
| title_fullStr | Mortality and Morbidity of Extremely Low Birth Weight Infants in the Mainland of China: A Multi-center Study |
| title_full_unstemmed | Mortality and Morbidity of Extremely Low Birth Weight Infants in the Mainland of China: A Multi-center Study |
| title_short | Mortality and Morbidity of Extremely Low Birth Weight Infants in the Mainland of China: A Multi-center Study |
| title_sort | mortality and morbidity of extremely low birth weight infants in the mainland of china a multi center study |
| topic | Extremely Low Birth Weight; Infant; Mortality; National Survey |
| url | http://www.cmj.org/article.asp?issn=0366-6999;year=2015;volume=128;issue=20;spage=2743;epage=2750;aulast=Lin |
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