The NLRP3 Inflammasome Pathway: A Review of Mechanisms and Inhibitors for the Treatment of Inflammatory Diseases

The NLRP3 Inflammasome Pathway: A Review of Mechanisms and Inhibitors for the Treatment of Inflammatory Diseases

The NLRP3 inflammasome is a multiprotein complex that plays a pivotal role in regulating the innate immune system and inflammatory signaling. Upon activation by PAMPs and DAMPs, NLRP3 oligomerizes and activates caspase-1 which initiates the processing and release of pro-inflammatory cytokines IL-1β...

Full description

Bibliographic Details
Main Authors: Hallie M. Blevins, Yiming Xu, Savannah Biby, Shijun Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Aging Neuroscience
Subjects:
NLRP3
inflammasome
NOD-like receptor
innate immune system
inhibitors
inflammatory diseases
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2022.879021/full

Similar Items

Similar Items