Collaboration between Colentina Clinical Hospital and the transplant centers: A chance for life
Background. Stem cell transplantation is an important therapeutic approach for patients with malignant hemopathies, whether we refer to autologous or allogeneic stem cell transplantation. Aims and methods. We present the characteristics of a group of 54 patients diagnosed with malignant haemopathy...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Amaltea Medical Publishing House
2021-06-01
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| Series: | Romanian Journal of Medical Practice |
| Subjects: | |
| Online Access: | https://rjmp.com.ro/articles/2021.2/RJMP_2021_2_Art-26.pdf |
| _version_ | 1818590437502353408 |
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| author | Georgeta Daniela GEORGESCU Felicia MIHAI Meilin OMER Viola POPOV Mihaela ANDREESCU Mihaela POPESCU Oana PATRINOIU Geanina OFITERU Marius BALEA Silvia ION Silvia CIORTAN Claudia DESPAN |
| author_facet | Georgeta Daniela GEORGESCU Felicia MIHAI Meilin OMER Viola POPOV Mihaela ANDREESCU Mihaela POPESCU Oana PATRINOIU Geanina OFITERU Marius BALEA Silvia ION Silvia CIORTAN Claudia DESPAN |
| author_sort | Georgeta Daniela GEORGESCU |
| collection | DOAJ |
| description | Background. Stem cell transplantation is an important therapeutic approach for patients with malignant
hemopathies, whether we refer to autologous or allogeneic stem cell transplantation.
Aims and methods. We present the characteristics of a group of 54 patients diagnosed with malignant haemopathy in the Department of Hematology of the Colentina Clinical Hospital, between 2004 and 2018, and who have benefited from stem cell transplantation both in the country and abroad. The data analyzed were: diagnosis of the disease, type of response to induction therapy, type and timing of transplantation, transplant in first remission or relapse, if there were patients who benefited from a second transplant, post-transplant survival, as well as demographics.
The statistical analysis was performed using the system MedCalc Statistical Software Version 18.11.3.
Results and conclusions. Survival analysis was applied separately for autotransplant patients and those who benefited from allotransplant (Kaplan Meier survival analyses). Significant differences were observed due to transplantation type and due to relapse after transplant, in our lot of patients. Post-transplant recurrence was an unfavorable prognostic factor for both autologous and allogeneic transplanted patients.
Update. A new challenge: The COVID-19 pandemic threat. The SARS-CoV-2 infection is a threat for immunocompromised patients. From a group of 9 patients hospitalized in 2020 for COVID-19 in the Department of Hematology of the Colentina Clinical Hospital, and who have benefited in the past from stem cell transplantation (2 patients) or organ transplant (1 patient – lung, 3 patients – liver, 3 patients – kidney) in Romania, 4 of them have required hospitalization in the Intensive Care Unit (ICU) (authors's observational data).
New data are needed to elucidate the prognostic factors to establish the outcome of transplant patients such as for all cancer patients or immunocompromised patients in the current COVID pandemic 19 era and the impact on public health. |
| first_indexed | 2024-12-16T09:56:32Z |
| format | Article |
| id | doaj.art-d405c119d64748aab8410d03c6ba1931 |
| institution | Directory Open Access Journal |
| issn | 1842-8258 2069-6108 |
| language | English |
| last_indexed | 2024-12-16T09:56:32Z |
| publishDate | 2021-06-01 |
| publisher | Amaltea Medical Publishing House |
| record_format | Article |
| series | Romanian Journal of Medical Practice |
| spelling | doaj.art-d405c119d64748aab8410d03c6ba19312022-12-21T22:35:54ZengAmaltea Medical Publishing HouseRomanian Journal of Medical Practice1842-82582069-61082021-06-0116226527210.37897/RJMP.2021.2.26Collaboration between Colentina Clinical Hospital and the transplant centers: A chance for lifeGeorgeta Daniela GEORGESCU0Felicia MIHAI1Meilin OMER2Viola POPOV3Mihaela ANDREESCU4Mihaela POPESCU5Oana PATRINOIU6Geanina OFITERU7Marius BALEA8Silvia ION9Silvia CIORTAN10Claudia DESPAN11Hematology Department, Colentina Clinical Hospital, Bucharest, RomaniaHematology Department, Colentina Clinical Hospital, Bucharest, RomaniaHematology Department, Colentina Clinical Hospital, Bucharest, RomaniaHematology Department, Colentina Clinical Hospital, Bucharest, RomaniaHematology Department, Colentina Clinical Hospital, Bucharest, RomaniaHematology Department, Colentina Clinical Hospital, Bucharest, RomaniaHematology Department, Colentina Clinical Hospital, Bucharest, RomaniaHematology Department, Colentina Clinical Hospital, Bucharest, RomaniaHematology Department, Colentina Clinical Hospital, Bucharest, RomaniaHematology Department, Colentina Clinical Hospital, Bucharest, RomaniaHematology Department, Colentina Clinical Hospital, Bucharest, RomaniaHematology Department, Colentina Clinical Hospital, Bucharest, RomaniaBackground. Stem cell transplantation is an important therapeutic approach for patients with malignant hemopathies, whether we refer to autologous or allogeneic stem cell transplantation. Aims and methods. We present the characteristics of a group of 54 patients diagnosed with malignant haemopathy in the Department of Hematology of the Colentina Clinical Hospital, between 2004 and 2018, and who have benefited from stem cell transplantation both in the country and abroad. The data analyzed were: diagnosis of the disease, type of response to induction therapy, type and timing of transplantation, transplant in first remission or relapse, if there were patients who benefited from a second transplant, post-transplant survival, as well as demographics. The statistical analysis was performed using the system MedCalc Statistical Software Version 18.11.3. Results and conclusions. Survival analysis was applied separately for autotransplant patients and those who benefited from allotransplant (Kaplan Meier survival analyses). Significant differences were observed due to transplantation type and due to relapse after transplant, in our lot of patients. Post-transplant recurrence was an unfavorable prognostic factor for both autologous and allogeneic transplanted patients. Update. A new challenge: The COVID-19 pandemic threat. The SARS-CoV-2 infection is a threat for immunocompromised patients. From a group of 9 patients hospitalized in 2020 for COVID-19 in the Department of Hematology of the Colentina Clinical Hospital, and who have benefited in the past from stem cell transplantation (2 patients) or organ transplant (1 patient – lung, 3 patients – liver, 3 patients – kidney) in Romania, 4 of them have required hospitalization in the Intensive Care Unit (ICU) (authors's observational data). New data are needed to elucidate the prognostic factors to establish the outcome of transplant patients such as for all cancer patients or immunocompromised patients in the current COVID pandemic 19 era and the impact on public health.https://rjmp.com.ro/articles/2021.2/RJMP_2021_2_Art-26.pdftransplantationhemopathiesdatabasecovid-19 |
| spellingShingle | Georgeta Daniela GEORGESCU Felicia MIHAI Meilin OMER Viola POPOV Mihaela ANDREESCU Mihaela POPESCU Oana PATRINOIU Geanina OFITERU Marius BALEA Silvia ION Silvia CIORTAN Claudia DESPAN Collaboration between Colentina Clinical Hospital and the transplant centers: A chance for life Romanian Journal of Medical Practice transplantation hemopathies database covid-19 |
| title | Collaboration between Colentina Clinical Hospital and the transplant centers: A chance for life |
| title_full | Collaboration between Colentina Clinical Hospital and the transplant centers: A chance for life |
| title_fullStr | Collaboration between Colentina Clinical Hospital and the transplant centers: A chance for life |
| title_full_unstemmed | Collaboration between Colentina Clinical Hospital and the transplant centers: A chance for life |
| title_short | Collaboration between Colentina Clinical Hospital and the transplant centers: A chance for life |
| title_sort | collaboration between colentina clinical hospital and the transplant centers a chance for life |
| topic | transplantation hemopathies database covid-19 |
| url | https://rjmp.com.ro/articles/2021.2/RJMP_2021_2_Art-26.pdf |
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