Do geography and ethnicity play a role in juvenile Spondyloarthritis? A multi-center binational retrospective study
Abstract Background Observations among Israeli pediatric rheumatologists reveal that pediatric Juvenile Spondyloarthritis (JSpA) may present differently compared to patients from the United States (US). This study is aimed to compare the demographic and clinical variables of Israeli and US JSpA pati...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-01-01
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| Series: | Pediatric Rheumatology Online Journal |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12969-020-00489-8 |
| _version_ | 1818453302382166016 |
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| author | Nassem Ghantous Merav Heshin-Bekenstein Kimberly Dequattro Yaniv Lakovsky Amir Moshe Hendel Nadav Rappoport Yonatan Butbul Aviel Irit Tirosh Liora Harel Pamela F. Weiss Lianne Gensler John Mackenzie Gil Amarilyo |
| author_facet | Nassem Ghantous Merav Heshin-Bekenstein Kimberly Dequattro Yaniv Lakovsky Amir Moshe Hendel Nadav Rappoport Yonatan Butbul Aviel Irit Tirosh Liora Harel Pamela F. Weiss Lianne Gensler John Mackenzie Gil Amarilyo |
| author_sort | Nassem Ghantous |
| collection | DOAJ |
| description | Abstract Background Observations among Israeli pediatric rheumatologists reveal that pediatric Juvenile Spondyloarthritis (JSpA) may present differently compared to patients from the United States (US). This study is aimed to compare the demographic and clinical variables of Israeli and US JSpA patients upon presentation. Methods We performed a retrospective, cross-sectional, multicenter comparison of JSpA patients among 3 large Israeli pediatric rheumatology centers and a large US pediatric rheumatology center. Patients with diagnosis of Juvenile Ankylosing Spondylitis (JAS) and/or Enthesitis-related Arthritis (ERA) were included. The demographic, clinical and radiologic features were compared. Results Overall 87 patients were included (39 Israeli, 48 US patients). Upon presentation, inflammatory back pain, sacroiliac joint tenderness and abnormal modified Schober test, were significantly more prevalent among Israeli patients (59% vs. 35.4, 48.7% vs. 16.7, and 41.2% vs. 21.5%, respectively, all p < 0.05), whereas peripheral arthritis and enthesitis were significantly more prevalent among US patients (43.6% vs. 91.7 and 7.7% vs. 39.6% in Israeli patients vs. US patients, p < 0.05). In addition, 96.7% of the Israeli patients versus 29.7% of the US patients demonstrated sacroiliitis on MRI (p < 0.001, N = 67). Less than one-third of the Israeli patients (32%) were HLA-B27 positive vs. 66.7% of US patients (p = 0.007). Conclusion Israeli children with JSpA presented almost exclusively with axial disease compared to US patients who were more likely to present with peripheral symptoms. HLA B27 prevalence was significantly lower in the Israeli cohort compared to the US cohort. Further studies are needed to unravel the genetic and possibly environmental factors associated with these findings. |
| first_indexed | 2024-12-14T21:36:50Z |
| format | Article |
| id | doaj.art-d407e6244b6043c7981858cb78c90ac1 |
| institution | Directory Open Access Journal |
| issn | 1546-0096 |
| language | English |
| last_indexed | 2024-12-14T21:36:50Z |
| publishDate | 2021-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Pediatric Rheumatology Online Journal |
| spelling | doaj.art-d407e6244b6043c7981858cb78c90ac12022-12-21T22:46:34ZengBMCPediatric Rheumatology Online Journal1546-00962021-01-011911810.1186/s12969-020-00489-8Do geography and ethnicity play a role in juvenile Spondyloarthritis? A multi-center binational retrospective studyNassem Ghantous0Merav Heshin-Bekenstein1Kimberly Dequattro2Yaniv Lakovsky3Amir Moshe Hendel4Nadav Rappoport5Yonatan Butbul Aviel6Irit Tirosh7Liora Harel8Pamela F. Weiss9Lianne Gensler10John Mackenzie11Gil Amarilyo12Sackler Faculty of Medicine, Tel Aviv UniversitySackler Faculty of Medicine, Tel Aviv UniversitySchool of Medicine, University of CaliforniaSackler Faculty of Medicine, Tel Aviv UniversitySackler Faculty of Medicine, Tel Aviv UniversitySchool of Medicine, University of CaliforniaRambam Medical CenterSheba Medical CenterSackler Faculty of Medicine, Tel Aviv UniversityChildren’s Hospital of Philadelphia, Perelman School of Medicine, University of PennsylvaniaSchool of Medicine, University of CaliforniaSchool of Medicine, University of CaliforniaSackler Faculty of Medicine, Tel Aviv UniversityAbstract Background Observations among Israeli pediatric rheumatologists reveal that pediatric Juvenile Spondyloarthritis (JSpA) may present differently compared to patients from the United States (US). This study is aimed to compare the demographic and clinical variables of Israeli and US JSpA patients upon presentation. Methods We performed a retrospective, cross-sectional, multicenter comparison of JSpA patients among 3 large Israeli pediatric rheumatology centers and a large US pediatric rheumatology center. Patients with diagnosis of Juvenile Ankylosing Spondylitis (JAS) and/or Enthesitis-related Arthritis (ERA) were included. The demographic, clinical and radiologic features were compared. Results Overall 87 patients were included (39 Israeli, 48 US patients). Upon presentation, inflammatory back pain, sacroiliac joint tenderness and abnormal modified Schober test, were significantly more prevalent among Israeli patients (59% vs. 35.4, 48.7% vs. 16.7, and 41.2% vs. 21.5%, respectively, all p < 0.05), whereas peripheral arthritis and enthesitis were significantly more prevalent among US patients (43.6% vs. 91.7 and 7.7% vs. 39.6% in Israeli patients vs. US patients, p < 0.05). In addition, 96.7% of the Israeli patients versus 29.7% of the US patients demonstrated sacroiliitis on MRI (p < 0.001, N = 67). Less than one-third of the Israeli patients (32%) were HLA-B27 positive vs. 66.7% of US patients (p = 0.007). Conclusion Israeli children with JSpA presented almost exclusively with axial disease compared to US patients who were more likely to present with peripheral symptoms. HLA B27 prevalence was significantly lower in the Israeli cohort compared to the US cohort. Further studies are needed to unravel the genetic and possibly environmental factors associated with these findings.https://doi.org/10.1186/s12969-020-00489-8Juvenile SpondyloarthritisEnthesitis related arthritisJuvenile SacroiliitisHLA B27 |
| spellingShingle | Nassem Ghantous Merav Heshin-Bekenstein Kimberly Dequattro Yaniv Lakovsky Amir Moshe Hendel Nadav Rappoport Yonatan Butbul Aviel Irit Tirosh Liora Harel Pamela F. Weiss Lianne Gensler John Mackenzie Gil Amarilyo Do geography and ethnicity play a role in juvenile Spondyloarthritis? A multi-center binational retrospective study Pediatric Rheumatology Online Journal Juvenile Spondyloarthritis Enthesitis related arthritis Juvenile Sacroiliitis HLA B27 |
| title | Do geography and ethnicity play a role in juvenile Spondyloarthritis? A multi-center binational retrospective study |
| title_full | Do geography and ethnicity play a role in juvenile Spondyloarthritis? A multi-center binational retrospective study |
| title_fullStr | Do geography and ethnicity play a role in juvenile Spondyloarthritis? A multi-center binational retrospective study |
| title_full_unstemmed | Do geography and ethnicity play a role in juvenile Spondyloarthritis? A multi-center binational retrospective study |
| title_short | Do geography and ethnicity play a role in juvenile Spondyloarthritis? A multi-center binational retrospective study |
| title_sort | do geography and ethnicity play a role in juvenile spondyloarthritis a multi center binational retrospective study |
| topic | Juvenile Spondyloarthritis Enthesitis related arthritis Juvenile Sacroiliitis HLA B27 |
| url | https://doi.org/10.1186/s12969-020-00489-8 |
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