Epigenetic Regulation of Glycosylation in Cancer and Other Diseases
In the last few decades, the newly emerging field of epigenetic regulation of glycosylation acquired more importance because it is unraveling physiological and pathological mechanisms related to glycan functions. Glycosylation is a complex process in which proteins and lipids are modified by the att...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-03-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/6/2980 |
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| author | Rossella Indellicato Marco Trinchera |
| author_facet | Rossella Indellicato Marco Trinchera |
| author_sort | Rossella Indellicato |
| collection | DOAJ |
| description | In the last few decades, the newly emerging field of epigenetic regulation of glycosylation acquired more importance because it is unraveling physiological and pathological mechanisms related to glycan functions. Glycosylation is a complex process in which proteins and lipids are modified by the attachment of monosaccharides. The main actors in this kind of modification are the glycoenzymes, which are translated from glycosylation-related genes (or glycogenes). The expression of glycogenes is regulated by transcription factors and epigenetic mechanisms (mainly DNA methylation, histone acetylation and noncoding RNAs). This review focuses only on these last ones, in relation to cancer and other diseases, such as inflammatory bowel disease and IgA1 nephropathy. In fact, it is clear that a deeper knowledge in the fine-tuning of glycogenes is essential for acquiring new insights in the glycan field, especially if this could be useful for finding novel and personalized therapeutics. |
| first_indexed | 2024-03-10T13:13:53Z |
| format | Article |
| id | doaj.art-d40ab5540fb94cb4a04eaa02cd0804c9 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T13:13:53Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-d40ab5540fb94cb4a04eaa02cd0804c92023-11-21T10:34:43ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-03-01226298010.3390/ijms22062980Epigenetic Regulation of Glycosylation in Cancer and Other DiseasesRossella Indellicato0Marco Trinchera1Department of Health Sciences, University of Milan, 20142 Milan, ItalyDepartment of Medicine and Surgery, University of Insubria, 21100 Varese, ItalyIn the last few decades, the newly emerging field of epigenetic regulation of glycosylation acquired more importance because it is unraveling physiological and pathological mechanisms related to glycan functions. Glycosylation is a complex process in which proteins and lipids are modified by the attachment of monosaccharides. The main actors in this kind of modification are the glycoenzymes, which are translated from glycosylation-related genes (or glycogenes). The expression of glycogenes is regulated by transcription factors and epigenetic mechanisms (mainly DNA methylation, histone acetylation and noncoding RNAs). This review focuses only on these last ones, in relation to cancer and other diseases, such as inflammatory bowel disease and IgA1 nephropathy. In fact, it is clear that a deeper knowledge in the fine-tuning of glycogenes is essential for acquiring new insights in the glycan field, especially if this could be useful for finding novel and personalized therapeutics.https://www.mdpi.com/1422-0067/22/6/2980epigeneticsmethylationhistone acetylationmiRNAsglycosylationglycogenes |
| spellingShingle | Rossella Indellicato Marco Trinchera Epigenetic Regulation of Glycosylation in Cancer and Other Diseases International Journal of Molecular Sciences epigenetics methylation histone acetylation miRNAs glycosylation glycogenes |
| title | Epigenetic Regulation of Glycosylation in Cancer and Other Diseases |
| title_full | Epigenetic Regulation of Glycosylation in Cancer and Other Diseases |
| title_fullStr | Epigenetic Regulation of Glycosylation in Cancer and Other Diseases |
| title_full_unstemmed | Epigenetic Regulation of Glycosylation in Cancer and Other Diseases |
| title_short | Epigenetic Regulation of Glycosylation in Cancer and Other Diseases |
| title_sort | epigenetic regulation of glycosylation in cancer and other diseases |
| topic | epigenetics methylation histone acetylation miRNAs glycosylation glycogenes |
| url | https://www.mdpi.com/1422-0067/22/6/2980 |
| work_keys_str_mv | AT rossellaindellicato epigeneticregulationofglycosylationincancerandotherdiseases AT marcotrinchera epigeneticregulationofglycosylationincancerandotherdiseases |