Dexamethasone Administration in Mice Leads to Less Body Weight Gain over Time, Lower Serum Glucose, and Higher Insulin Levels Independently of NRF2

Dexamethasone Administration in Mice Leads to Less Body Weight Gain over Time, Lower Serum Glucose, and Higher Insulin Levels Independently of NRF2

Glucocorticoids are used widely on a long-term basis in autoimmune and inflammatory diseases. Their adverse effects include the development of hyperglycemia and osteoporosis, whose molecular mechanisms have been only partially studied in preclinical models. Both these glucocorticoid-induced patholog...

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Bibliographic Details
Main Authors: Fotini Filippopoulou, George I. Habeos, Vagelis Rinotas, Antonia Sophocleous, Gerasimos P. Sykiotis, Eleni Douni, Dionysios V. Chartoumpekis
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Antioxidants
Subjects:
KEAP1
diabetes
glucocorticoids
osteoporosis
insulin resistance
gluconeogenesis
Online Access:https://www.mdpi.com/2076-3921/11/1/4

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