Phagocytosis of Erythrocytes from Gaucher Patients Induces Phenotypic Modifications in Macrophages, Driving Them toward Gaucher Cells

Phagocytosis of Erythrocytes from Gaucher Patients Induces Phenotypic Modifications in Macrophages, Driving Them toward Gaucher Cells

Gaucher disease (GD) is caused by glucocerebrosidase deficiency leading to the accumulation of sphingolipids in macrophages named “Gaucher’s Cells”. These cells are characterized by deregulated expression of cell surface markers, abnormal secretion of inflammatory cytokines, and iron sequestration....

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Bibliographic Details
Main Authors: Lucie Dupuis, Margaux Chauvet, Emmanuelle Bourdelier, Michaël Dussiot, Nadia Belmatoug, Caroline Le Van Kim, Arnaud Chêne, Mélanie Franco
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:International Journal of Molecular Sciences
Subjects:
red blood cells
erythrophagocytosis
macrophages
Gaucher disease
Online Access:https://www.mdpi.com/1422-0067/23/14/7640

Internet

https://www.mdpi.com/1422-0067/23/14/7640

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