Dynamical origins of heat capacity changes in enzyme-catalysed reactions
Heat capacity changes affect the temperature dependence of enzyme catalysis, with implications for thermoadaptation, however their physical basis is unknown. Here the authors show that heat capacity changes are calculable by simulation, revealing distinct dynamical contributions from regions remote...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2018-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-03597-y |
| _version_ | 1818991241764798464 |
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| author | Marc W. van der Kamp Erica J. Prentice Kirsty L. Kraakman Michael Connolly Adrian J. Mulholland Vickery L. Arcus |
| author_facet | Marc W. van der Kamp Erica J. Prentice Kirsty L. Kraakman Michael Connolly Adrian J. Mulholland Vickery L. Arcus |
| author_sort | Marc W. van der Kamp |
| collection | DOAJ |
| description | Heat capacity changes affect the temperature dependence of enzyme catalysis, with implications for thermoadaptation, however their physical basis is unknown. Here the authors show that heat capacity changes are calculable by simulation, revealing distinct dynamical contributions from regions remote from the active site. |
| first_indexed | 2024-12-20T20:07:09Z |
| format | Article |
| id | doaj.art-d40e1dcd15e6492cbf102e64d92191d2 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T20:07:09Z |
| publishDate | 2018-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-d40e1dcd15e6492cbf102e64d92191d22022-12-21T19:27:55ZengNature PortfolioNature Communications2041-17232018-03-01911710.1038/s41467-018-03597-yDynamical origins of heat capacity changes in enzyme-catalysed reactionsMarc W. van der Kamp0Erica J. Prentice1Kirsty L. Kraakman2Michael Connolly3Adrian J. Mulholland4Vickery L. Arcus5School of Biochemistry, Biomedical Sciences Building, University of BristolSchool of Science, University of WaikatoSchool of Science, University of WaikatoCentre of Computational Chemistry, School of Chemistry, University of BristolCentre of Computational Chemistry, School of Chemistry, University of BristolSchool of Science, University of WaikatoHeat capacity changes affect the temperature dependence of enzyme catalysis, with implications for thermoadaptation, however their physical basis is unknown. Here the authors show that heat capacity changes are calculable by simulation, revealing distinct dynamical contributions from regions remote from the active site.https://doi.org/10.1038/s41467-018-03597-y |
| spellingShingle | Marc W. van der Kamp Erica J. Prentice Kirsty L. Kraakman Michael Connolly Adrian J. Mulholland Vickery L. Arcus Dynamical origins of heat capacity changes in enzyme-catalysed reactions Nature Communications |
| title | Dynamical origins of heat capacity changes in enzyme-catalysed reactions |
| title_full | Dynamical origins of heat capacity changes in enzyme-catalysed reactions |
| title_fullStr | Dynamical origins of heat capacity changes in enzyme-catalysed reactions |
| title_full_unstemmed | Dynamical origins of heat capacity changes in enzyme-catalysed reactions |
| title_short | Dynamical origins of heat capacity changes in enzyme-catalysed reactions |
| title_sort | dynamical origins of heat capacity changes in enzyme catalysed reactions |
| url | https://doi.org/10.1038/s41467-018-03597-y |
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