Chinese herbal medicine and its active compounds in attenuating renal injury via regulating autophagy in diabetic kidney disease
Diabetic kidney disease (DKD) is the main cause of end-stage renal disease worldwide, and there is a lack of effective treatment strategies. Autophagy is a highly conserved lysosomal degradation process that maintains homeostasis and energy balance by removing protein aggregates and damaged organell...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1142805/full |
| _version_ | 1811160329930932224 |
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| author | Peng Liu Wenhui Zhu Yang Wang Guijie Ma Hailing Zhao Ping Li |
| author_facet | Peng Liu Wenhui Zhu Yang Wang Guijie Ma Hailing Zhao Ping Li |
| author_sort | Peng Liu |
| collection | DOAJ |
| description | Diabetic kidney disease (DKD) is the main cause of end-stage renal disease worldwide, and there is a lack of effective treatment strategies. Autophagy is a highly conserved lysosomal degradation process that maintains homeostasis and energy balance by removing protein aggregates and damaged organelles. Increasing evidence suggests that dysregulated autophagy may contribute to glomerular and tubulointerstitial lesions in the kidney under diabetic conditions. Emerging studies have shown that Chinese herbal medicine and its active compounds may ameliorate diabetic kidney injury by regulating autophagy. In this review, we summarize that dysregulation or insufficiency of autophagy in renal cells, including podocytes, glomerular mesangial cells, and proximal tubular epithelial cells, is a key mechanism for the development of DKD, and focus on the protective effects of Chinese herbal medicine and its active compounds. Moreover, we systematically reviewed the mechanism of autophagy in DKD regulated by Chinese herb compound preparations, single herb and active compounds, so as to provide new drug candidates for clinical treatment of DKD. Finally, we also reviewed the candidate targets of Chinese herbal medicine regulating autophagy for DKD. Therefore, further research on Chinese herbal medicine with autophagy regulation and their targets is of great significance for the realization of new targeted therapies for DKD. |
| first_indexed | 2024-04-10T05:55:33Z |
| format | Article |
| id | doaj.art-d40fcf9b7d46495ab3634904d848a256 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-10T05:55:33Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-d40fcf9b7d46495ab3634904d848a2562023-03-03T16:50:07ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-03-011410.3389/fendo.2023.11428051142805Chinese herbal medicine and its active compounds in attenuating renal injury via regulating autophagy in diabetic kidney diseasePeng Liu0Wenhui Zhu1Yang Wang2Guijie Ma3Hailing Zhao4Ping Li5Shunyi Hospital, Beijing Hospital of Traditional Chinese Medicine, Beijing, ChinaRenal Division, Department of Medicine, Heilongjiang Academy of Chinese Medicine Sciences, Harbin, ChinaRenal Division, Department of Medicine, Heilongjiang Academy of Chinese Medicine Sciences, Harbin, ChinaRenal Division, Department of Medicine, Heilongjiang Academy of Chinese Medicine Sciences, Harbin, ChinaBeijing Key Lab for Immune-Mediated Inflammatory Diseases, China-Japan Friendship Hospital, Beijing, ChinaBeijing Key Lab for Immune-Mediated Inflammatory Diseases, China-Japan Friendship Hospital, Beijing, ChinaDiabetic kidney disease (DKD) is the main cause of end-stage renal disease worldwide, and there is a lack of effective treatment strategies. Autophagy is a highly conserved lysosomal degradation process that maintains homeostasis and energy balance by removing protein aggregates and damaged organelles. Increasing evidence suggests that dysregulated autophagy may contribute to glomerular and tubulointerstitial lesions in the kidney under diabetic conditions. Emerging studies have shown that Chinese herbal medicine and its active compounds may ameliorate diabetic kidney injury by regulating autophagy. In this review, we summarize that dysregulation or insufficiency of autophagy in renal cells, including podocytes, glomerular mesangial cells, and proximal tubular epithelial cells, is a key mechanism for the development of DKD, and focus on the protective effects of Chinese herbal medicine and its active compounds. Moreover, we systematically reviewed the mechanism of autophagy in DKD regulated by Chinese herb compound preparations, single herb and active compounds, so as to provide new drug candidates for clinical treatment of DKD. Finally, we also reviewed the candidate targets of Chinese herbal medicine regulating autophagy for DKD. Therefore, further research on Chinese herbal medicine with autophagy regulation and their targets is of great significance for the realization of new targeted therapies for DKD.https://www.frontiersin.org/articles/10.3389/fendo.2023.1142805/fulldiabetic kidney disease (DKD)autophagyChinese medicineactive compoundsherbal extracts |
| spellingShingle | Peng Liu Wenhui Zhu Yang Wang Guijie Ma Hailing Zhao Ping Li Chinese herbal medicine and its active compounds in attenuating renal injury via regulating autophagy in diabetic kidney disease Frontiers in Endocrinology diabetic kidney disease (DKD) autophagy Chinese medicine active compounds herbal extracts |
| title | Chinese herbal medicine and its active compounds in attenuating renal injury via regulating autophagy in diabetic kidney disease |
| title_full | Chinese herbal medicine and its active compounds in attenuating renal injury via regulating autophagy in diabetic kidney disease |
| title_fullStr | Chinese herbal medicine and its active compounds in attenuating renal injury via regulating autophagy in diabetic kidney disease |
| title_full_unstemmed | Chinese herbal medicine and its active compounds in attenuating renal injury via regulating autophagy in diabetic kidney disease |
| title_short | Chinese herbal medicine and its active compounds in attenuating renal injury via regulating autophagy in diabetic kidney disease |
| title_sort | chinese herbal medicine and its active compounds in attenuating renal injury via regulating autophagy in diabetic kidney disease |
| topic | diabetic kidney disease (DKD) autophagy Chinese medicine active compounds herbal extracts |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1142805/full |
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