Regulation of GIP and GLP1 receptor cell surface expression by N-glycosylation and receptor heteromerization.

Regulation of GIP and GLP1 receptor cell surface expression by N-glycosylation and receptor heteromerization.

In response to a meal, Glucose-dependent Insulinotropic Polypeptide (GIP) and Glucagon-like Peptide-1 (GLP-1) are released from gut endocrine cells into the circulation and interact with their cognate G-protein coupled receptors (GPCRs). Receptor activation results in tissue-selective pleiotropic re...

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Bibliographic Details
Main Authors: Gina M Whitaker, Francis C Lynn, Christopher H S McIntosh, Eric A Accili
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3296735?pdf=render

Internet

http://europepmc.org/articles/PMC3296735?pdf=render

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