Mutational landscape of inflammatory breast cancer

Mutational landscape of inflammatory breast cancer

Abstract Background Inflammatory breast cancer (IBC) is the most pro-metastatic form of BC. Better understanding of its enigmatic pathophysiology is crucial. We report here the largest whole-exome sequencing (WES) study of clinical IBC samples. Methods We retrospectively applied WES to 54 untreated...

Full description

Bibliographic Details
Main Authors:	François Bertucci, Florence Lerebours, Michele Ceccarelli, Arnaud Guille, Najeeb Syed, Pascal Finetti, José Adélaïde, Steven Van Laere, Anthony Goncalves, Patrice Viens, Daniel Birnbaum, Emilie Mamessier, Céline Callens, Davide Bedognetti
Format:	Article
Language:	English
Published:	BMC 2024-04-01
Series:	Journal of Translational Medicine
Subjects:	Inflammatory breast cancer Copy number alteration Mutation Whole-exome sequencing
Online Access:	https://doi.org/10.1186/s12967-024-05198-4

Similar Items

Whole-genome/exome analysis of circulating tumor DNA and comparison to tumor genomics from patients with heavily pre-treated ovarian cancer: subset analysis of the PERMED-01 trial
by: Renaud Sabatier, et al.
Published: (2022-07-01)

Circulating tumor DNA predicts efficacy of a dual AKT/p70S6K inhibitor (LY2780301) plus paclitaxel in metastatic breast cancer: plasma analysis of the TAKTIC phase IB/II study
by: Renaud Sabatier, et al.
Published: (2022-05-01)

Investigation of Molecular Features Involved in Clinical Responses and Survival in Advanced Endometrial Carcinoma Treated by Hormone Therapy
by: Mathias Neron, et al.
Published: (2022-04-01)

A Comparison of DNA Mutation and Copy Number Profiles of Primary Breast Cancers and Paired Brain Metastases for Identifying Clinically Relevant Genetic Alterations in Brain Metastases
by: Marguerite Tyran, et al.
Published: (2019-05-01)

A Tyrosine Kinase Expression Signature Predicts the Post-Operative Clinical Outcome in Triple Negative Breast Cancers
by: Alexandre de Nonneville, et al.
Published: (2019-08-01)

Genomic Analysis Made It Possible to Identify Gene-Driver Alterations Covering the Time Window between Diagnosis of Neuroblastoma 4S and the Progression to Stage 4
by: Marzia Ognibene, et al.
Published: (2022-06-01)

Read Count Patterns and Detection of Cancerous Copy Number Alterations in Plasma Cell-Free DNA Whole Exome Sequencing Data for Advanced Non-Small Cell Lung Cancer
by: Ho Jang, et al.
Published: (2022-10-01)

Co-Occurrence of Germline Genomic Variants and Copy Number Variations in Hereditary Breast and Colorectal Cancer Patients
by: Luiza Côrtes, et al.
Published: (2023-08-01)

Rare Tumor-Normal Matched Whole Exome Sequencing Identifies Novel Genomic Pathogenic Germline and Somatic Aberrations
by: Ryan Sprissler, et al.
Published: (2020-06-01)

Head and Body/Tail Pancreatic Carcinomas Are Not the Same Tumors
by: David Jérémie Birnbaum, et al.
Published: (2019-04-01)

Early contribution of germline and nevi genetic alterations to a rapidly-progressing cutaneous melanoma patient: a case report
by: Ana Mordoh, et al.
Published: (2023-01-01)

Whole Exome Sequencing of Thymoma Patients Exhibiting Exceptional Responses to Pemetrexed Monotherapy
by: Tomohiro Tanaka, et al.
Published: (2023-08-01)

Case report: Fetal cervical immature teratoma and copy number variations
by: Dianjie Li, et al.
Published: (2022-08-01)

Germline CNV Detection through Whole-Exome Sequencing (WES) Data Analysis Enhances Resolution of Rare Genetic Diseases
by: Faidon-Nikolaos Tilemis, et al.
Published: (2023-07-01)

Analysis of the Association between Copy Number Variation and Ventricular Fibrillation in ST-Elevation Acute Myocardial Infarction
by: Roberto Lorente-Bermúdez, et al.
Published: (2024-02-01)

Intellectual disability in two Chinese sisters caused by a 3p26.3p25.3 microdeletion and a 14q32.13q32.33 microduplication inherited from the mother with 46, XX, t (3, 14) (p25; q32)
by: Ying Dai, et al.
Published: (2020-08-01)

A Study of the Genomic Variations Associated with Autistic Spectrum Disorders in a Russian Cohort of Patients Using Whole-Exome Sequencing
by: Ekaterina A. Gibitova, et al.
Published: (2022-05-01)

Genetic and clinical approach to macrocephaly: a 5-year single-center study
by: Muhsin Elmas, et al.
Published: (2020-12-01)

Evolutionary Trajectories and Genomic Divergence in Localized Breast Cancers after Ipsilateral Breast Tumor Recurrence
by: Chia-Hsin Wu, et al.
Published: (2021-04-01)

Specific genetic aberrations of parathyroid in Chinese patients with tertiary hyperparathyroidism using whole-exome sequencing
by: Lei Li, et al.
Published: (2023-10-01)

Chromosomal microarray and whole‐exome sequence analysis in Taiwanese patients with autism spectrum disorder
by: Ya‐Sian Chang, et al.
Published: (2019-12-01)

A Comparison of Tools for Copy-Number Variation Detection in Germline Whole Exome and Whole Genome Sequencing Data
by: Migle Gabrielaite, et al.
Published: (2021-12-01)

Copy Number Alterations as Novel Biomarkers and Therapeutic Targets in Colorectal Cancer
by: Elaine S. Tan, et al.
Published: (2022-04-01)

Tumor copy number alteration burden is a pan-cancer prognostic factor associated with recurrence and death
by: Haley Hieronymus, et al.
Published: (2018-09-01)

Developmental Delay/Mental Retardation of Unknown Origin in Children: Genetic Analysis of 93 Cases
by: WANG Jing, LIU Yun, HUANG Haoyu, WU Jinting, LIU Chunming, ZHANG Yangping, WANG Wenjuan
Published: (2023-03-01)

Whole-Exome Sequencing Reveals Mutational Signature of Hypertrophic Cardiomyopathy
by: Wang XQ, et al.
Published: (2023-10-01)

Comparative study of whole exome sequencing-based copy number variation detection tools
by: Lanling Zhao, et al.
Published: (2020-03-01)

Parallel Tests of Whole Exome Sequencing and Copy Number Variant Sequencing Increase the Diagnosis Yields of Rare Pediatric Disorders
by: Xuyun Hu, et al.
Published: (2020-06-01)

Algorithmic improvements for discovery of germline copy number variants in next-generation sequencing data
by: Brendan O’Fallon, et al.
Published: (2022-07-01)

Diagnostic Yields of Trio-WES Accompanied by CNVseq for Rare Neurodevelopmental Disorders
by: Chao Gao, et al.
Published: (2019-05-01)

Genomic alterations in neuroendocrine prostate cancer: A systematic review and meta‐analysis
by: Junru Chen, et al.
Published: (2023-05-01)

Prognostic and Predictive Value of <i>LIV1</i> Expression in Early Breast Cancer and by Molecular Subtype
by: Alexandre de Nonneville, et al.
Published: (2023-03-01)

The MonarchE trial: improving the clinical outcome in HR+/HER2− early breast cancer: recent results and next steps
by: François Bertucci, et al.
Published: (2023-08-01)

Predictive power of tertiary lymphoid structure signature for neoadjuvant chemotherapy response and immunotherapy benefit in HER2‐negative breast cancer
by: François Bertucci, et al.
Published: (2023-08-01)

Editorial: Next generation sequencing (NGS) for rare diseases diagnosis ‐ Volume II
by: Xiu-An Yang, et al.
Published: (2023-07-01)

Comprehensive analysis of age‐related somatic mutation profiles in Chinese young lung adenocarcinoma patients
by: Bo Yang, et al.
Published: (2019-04-01)

Comprehensive Analysis of Genomic Alterations in Hepatoid Adenocarcinoma of the Stomach and Identification of Clinically Actionable Alterations
by: Rongjie Zhao, et al.
Published: (2022-08-01)

Immunologic constant of rejection as a predictive biomarker of immune checkpoint inhibitors efficacy in non-small cell lung cancer
by: Alice Mogenet, et al.
Published: (2023-09-01)

Whole-exome sequencing of oral epithelial dysplasia samples reveals an association with new genes
by: Daniela ADORNO-FARIAS, et al.
Published: (2023-02-01)

Genetic interrogation for sequence and copy number variants in systemic lupus erythematosus
by: Nicholas Kim-Wah Yeo, et al.
Published: (2024-03-01)