The contribution of pattern recognition receptor signalling in the development of age related macular degeneration: the role of toll-like-receptors and the NLRP3-inflammasome

The contribution of pattern recognition receptor signalling in the development of age related macular degeneration: the role of toll-like-receptors and the NLRP3-inflammasome

Abstract Age-related macular degeneration (AMD) is a leading cause of irreversible vision loss, characterised by the dysfunction and death of the photoreceptors and retinal pigment epithelium (RPE). Innate immune cell activation and accompanying para-inflammation have been suggested to contribute to...

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Bibliographic Details
Main Authors: Alice Brandli, Kirstan A. Vessey, Erica L. Fletcher
Format: Article
Language:English
Published: BMC 2024-03-01
Series:Journal of Neuroinflammation
Subjects:
Microglia
Retinal degeneration
Pattern recognition receptor
Age related macular degeneration
Innate immunity
Toll-like receptors
Online Access:https://doi.org/10.1186/s12974-024-03055-1

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