ESX-1-induced apoptosis during mycobacterial infection: to be or not to be, that is the question
The major Mycobacterium tuberculosis virulence factor ESAT-6 exported by the ESX-1 secretion system has been described as a pro-apoptotic factor by several independent groups in recent years, sustaining a role for apoptosis in M. tuberculosis pathogenesis. This role has been supported by independent...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2013-12-01
|
| Series: | Frontiers in Cellular and Infection Microbiology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fcimb.2013.00088/full |
| _version_ | 1817969735015333888 |
|---|---|
| author | Juan I Aguilo Juan I Aguilo Dessislava eMarinova Dessislava eMarinova Carlos eMartin Carlos eMartin Julian ePardo Julian ePardo Julian ePardo |
| author_facet | Juan I Aguilo Juan I Aguilo Dessislava eMarinova Dessislava eMarinova Carlos eMartin Carlos eMartin Julian ePardo Julian ePardo Julian ePardo |
| author_sort | Juan I Aguilo |
| collection | DOAJ |
| description | The major Mycobacterium tuberculosis virulence factor ESAT-6 exported by the ESX-1 secretion system has been described as a pro-apoptotic factor by several independent groups in recent years, sustaining a role for apoptosis in M. tuberculosis pathogenesis. This role has been supported by independent studies in which apoptosis has been shown as a hallmark feature in human and mouse lungs infected with virulent strains. Nevertheless, the role of apoptosis during mycobacterial infection is subject to an intense debate. Several works maintain that apoptosis is more evident with attenuated strains, whereas virulent mycobacteria tend to inhibit this process, suggesting that apoptosis induction may be a host mechanism to control infection. In this review, we summarize the evidences that support the involvement of ESX-1-induced apoptosis in virulence, intending to provide a rational treatise for the role of programmed cell death during M. tuberculosis infection. |
| first_indexed | 2024-04-13T20:25:17Z |
| format | Article |
| id | doaj.art-d414ab722fd347979a7159910ab0b3b9 |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-04-13T20:25:17Z |
| publishDate | 2013-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-d414ab722fd347979a7159910ab0b3b92022-12-22T02:31:23ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882013-12-01310.3389/fcimb.2013.0008862260ESX-1-induced apoptosis during mycobacterial infection: to be or not to be, that is the questionJuan I Aguilo0Juan I Aguilo1Dessislava eMarinova2Dessislava eMarinova3Carlos eMartin4Carlos eMartin5Julian ePardo6Julian ePardo7Julian ePardo8University of ZaragozaCIBER Enfermedades RespiratoriasUniversity of ZaragozaCIBER Enfermedades RespiratoriasUniversity of ZaragozaCIBER Enfermedades RespiratoriasFundación Agencia Aragonesa para la Investigación y el Desarrollo (ARAID)University of ZaragozaUniversity of ZaragozaThe major Mycobacterium tuberculosis virulence factor ESAT-6 exported by the ESX-1 secretion system has been described as a pro-apoptotic factor by several independent groups in recent years, sustaining a role for apoptosis in M. tuberculosis pathogenesis. This role has been supported by independent studies in which apoptosis has been shown as a hallmark feature in human and mouse lungs infected with virulent strains. Nevertheless, the role of apoptosis during mycobacterial infection is subject to an intense debate. Several works maintain that apoptosis is more evident with attenuated strains, whereas virulent mycobacteria tend to inhibit this process, suggesting that apoptosis induction may be a host mechanism to control infection. In this review, we summarize the evidences that support the involvement of ESX-1-induced apoptosis in virulence, intending to provide a rational treatise for the role of programmed cell death during M. tuberculosis infection.http://journal.frontiersin.org/Journal/10.3389/fcimb.2013.00088/fullApoptosisCell DeathMycobacterium tuberculosisNecrosisVirulenceattenuated strains |
| spellingShingle | Juan I Aguilo Juan I Aguilo Dessislava eMarinova Dessislava eMarinova Carlos eMartin Carlos eMartin Julian ePardo Julian ePardo Julian ePardo ESX-1-induced apoptosis during mycobacterial infection: to be or not to be, that is the question Frontiers in Cellular and Infection Microbiology Apoptosis Cell Death Mycobacterium tuberculosis Necrosis Virulence attenuated strains |
| title | ESX-1-induced apoptosis during mycobacterial infection: to be or not to be, that is the question |
| title_full | ESX-1-induced apoptosis during mycobacterial infection: to be or not to be, that is the question |
| title_fullStr | ESX-1-induced apoptosis during mycobacterial infection: to be or not to be, that is the question |
| title_full_unstemmed | ESX-1-induced apoptosis during mycobacterial infection: to be or not to be, that is the question |
| title_short | ESX-1-induced apoptosis during mycobacterial infection: to be or not to be, that is the question |
| title_sort | esx 1 induced apoptosis during mycobacterial infection to be or not to be that is the question |
| topic | Apoptosis Cell Death Mycobacterium tuberculosis Necrosis Virulence attenuated strains |
| url | http://journal.frontiersin.org/Journal/10.3389/fcimb.2013.00088/full |
| work_keys_str_mv | AT juaniaguilo esx1inducedapoptosisduringmycobacterialinfectiontobeornottobethatisthequestion AT juaniaguilo esx1inducedapoptosisduringmycobacterialinfectiontobeornottobethatisthequestion AT dessislavaemarinova esx1inducedapoptosisduringmycobacterialinfectiontobeornottobethatisthequestion AT dessislavaemarinova esx1inducedapoptosisduringmycobacterialinfectiontobeornottobethatisthequestion AT carlosemartin esx1inducedapoptosisduringmycobacterialinfectiontobeornottobethatisthequestion AT carlosemartin esx1inducedapoptosisduringmycobacterialinfectiontobeornottobethatisthequestion AT julianepardo esx1inducedapoptosisduringmycobacterialinfectiontobeornottobethatisthequestion AT julianepardo esx1inducedapoptosisduringmycobacterialinfectiontobeornottobethatisthequestion AT julianepardo esx1inducedapoptosisduringmycobacterialinfectiontobeornottobethatisthequestion |