18F- FDG PET/CT helps differentiate autoimmune pancreatitis from pancreatic cancer
Abstract Background 18F-FDG PET/CT could satisfactorily show pancreatic and extra-pancreatic lesions in AIP, which can be mistaken for pancreatic cancer (PC). This study aimed to identify 18F-FDG PET/CT findings that might differentiate AIP from PC. Methods FDG-PET/CT findings of 26 AIP and 40 PC pa...
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| Format: | Article |
| Language: | English |
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BMC
2017-10-01
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| Series: | BMC Cancer |
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| Online Access: | http://link.springer.com/article/10.1186/s12885-017-3665-y |
| _version_ | 1818043733789114368 |
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| author | Jian Zhang Guorong Jia Changjing Zuo Ningyang Jia Hui Wang |
| author_facet | Jian Zhang Guorong Jia Changjing Zuo Ningyang Jia Hui Wang |
| author_sort | Jian Zhang |
| collection | DOAJ |
| description | Abstract Background 18F-FDG PET/CT could satisfactorily show pancreatic and extra-pancreatic lesions in AIP, which can be mistaken for pancreatic cancer (PC). This study aimed to identify 18F-FDG PET/CT findings that might differentiate AIP from PC. Methods FDG-PET/CT findings of 26 AIP and 40 PC patients were reviewed. Pancreatic and extra-pancreatic lesions related findings, including maximum standardized uptake values (SUVmax) and patterns of FDG uptake, were identified and compared. Results All 26 patients with AIP had increased pancreatic FDG uptake. Focal abnormal pancreatic FDG activities were found in 38/40 (95.00%) PC patients, while longitudinal were found in 18/26 (69.23%) AIP patients. SUVmax was significantly different between AIP and PC, both in early and delayed PET/CT scans (p < 0.05). AUCs were 0.700 (early SUVmax), 0.687 (delayed SUVmax), 0.683 (early lesions/liver SUVmax), and 0.715 (delayed lesion/liver SUVmax). Bile duct related abnormalities were found in 12/26 (46.15%) AIP and 10/40 (25.00%) PC patients, respectively. Incidentally, salivary and prostate gland SUVmax in AIP patients were higher compared with those of PC patients (p < 0.05). In males,an inverted “V” shaped high FDG uptake in the prostate was more frequent in AIP than PC patients (56.00%, 14/25 vs. 5.71%, 2/35). Increased FDG activity in extra-pancreatic bile duct was present in 4/26 of AIP patients, while was observed in none of the PC patients. Only in AIP patients, both diffuse pancreatic FDG accumulation and increased inverted “V” shaped FDG uptake in the prostate could be found simultaneously. Conclusions 18F-FDG PET/CT findings might help differentiate AIP from PC. |
| first_indexed | 2024-12-10T09:06:55Z |
| format | Article |
| id | doaj.art-d4159abcfc19447b882ae01db2826f0b |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-12-10T09:06:55Z |
| publishDate | 2017-10-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-d4159abcfc19447b882ae01db2826f0b2022-12-22T01:55:07ZengBMCBMC Cancer1471-24072017-10-011711910.1186/s12885-017-3665-y18F- FDG PET/CT helps differentiate autoimmune pancreatitis from pancreatic cancerJian Zhang0Guorong Jia1Changjing Zuo2Ningyang Jia3Hui Wang4Department of Nuclear Medicine, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of MedicineDepartment of Nuclear Medicine, Changhai Hospital, Second Military Medical UniversityDepartment of Nuclear Medicine, Changhai Hospital, Second Military Medical UniversityDepartment of Radiology, Eastern Hepatobiliary Surgery Hospital, Second Military Medical UniversityDepartment of Nuclear Medicine, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of MedicineAbstract Background 18F-FDG PET/CT could satisfactorily show pancreatic and extra-pancreatic lesions in AIP, which can be mistaken for pancreatic cancer (PC). This study aimed to identify 18F-FDG PET/CT findings that might differentiate AIP from PC. Methods FDG-PET/CT findings of 26 AIP and 40 PC patients were reviewed. Pancreatic and extra-pancreatic lesions related findings, including maximum standardized uptake values (SUVmax) and patterns of FDG uptake, were identified and compared. Results All 26 patients with AIP had increased pancreatic FDG uptake. Focal abnormal pancreatic FDG activities were found in 38/40 (95.00%) PC patients, while longitudinal were found in 18/26 (69.23%) AIP patients. SUVmax was significantly different between AIP and PC, both in early and delayed PET/CT scans (p < 0.05). AUCs were 0.700 (early SUVmax), 0.687 (delayed SUVmax), 0.683 (early lesions/liver SUVmax), and 0.715 (delayed lesion/liver SUVmax). Bile duct related abnormalities were found in 12/26 (46.15%) AIP and 10/40 (25.00%) PC patients, respectively. Incidentally, salivary and prostate gland SUVmax in AIP patients were higher compared with those of PC patients (p < 0.05). In males,an inverted “V” shaped high FDG uptake in the prostate was more frequent in AIP than PC patients (56.00%, 14/25 vs. 5.71%, 2/35). Increased FDG activity in extra-pancreatic bile duct was present in 4/26 of AIP patients, while was observed in none of the PC patients. Only in AIP patients, both diffuse pancreatic FDG accumulation and increased inverted “V” shaped FDG uptake in the prostate could be found simultaneously. Conclusions 18F-FDG PET/CT findings might help differentiate AIP from PC.http://link.springer.com/article/10.1186/s12885-017-3665-yAutoimmune pancreatitisPancreatic cancerPositron-emission tomography |
| spellingShingle | Jian Zhang Guorong Jia Changjing Zuo Ningyang Jia Hui Wang 18F- FDG PET/CT helps differentiate autoimmune pancreatitis from pancreatic cancer BMC Cancer Autoimmune pancreatitis Pancreatic cancer Positron-emission tomography |
| title | 18F- FDG PET/CT helps differentiate autoimmune pancreatitis from pancreatic cancer |
| title_full | 18F- FDG PET/CT helps differentiate autoimmune pancreatitis from pancreatic cancer |
| title_fullStr | 18F- FDG PET/CT helps differentiate autoimmune pancreatitis from pancreatic cancer |
| title_full_unstemmed | 18F- FDG PET/CT helps differentiate autoimmune pancreatitis from pancreatic cancer |
| title_short | 18F- FDG PET/CT helps differentiate autoimmune pancreatitis from pancreatic cancer |
| title_sort | 18f fdg pet ct helps differentiate autoimmune pancreatitis from pancreatic cancer |
| topic | Autoimmune pancreatitis Pancreatic cancer Positron-emission tomography |
| url | http://link.springer.com/article/10.1186/s12885-017-3665-y |
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