Gyroid-based functionally graded porous titanium scaffolds for dental application: Design, simulation and characterizations
To improve the mechanical compatibility and biocompatibility of porous scaffolds for dental application, functionally graded porous titanium scaffolds with average porosity of 20–80 % were designed and fabricated by selective laser melting. Finite element modeling in the oral environment showed that...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-12-01
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| Series: | Materials & Design |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0264127522009224 |
| _version_ | 1811292080993992704 |
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| author | Wei Xu Aihua Yu Yu Jiang Yageng Li Ce Zhang Harsh-preet Singh Bowen Liu Chenjin Hou Yun Zhang Shiwei Tian Jiazhen Zhang Xin Lu |
| author_facet | Wei Xu Aihua Yu Yu Jiang Yageng Li Ce Zhang Harsh-preet Singh Bowen Liu Chenjin Hou Yun Zhang Shiwei Tian Jiazhen Zhang Xin Lu |
| author_sort | Wei Xu |
| collection | DOAJ |
| description | To improve the mechanical compatibility and biocompatibility of porous scaffolds for dental application, functionally graded porous titanium scaffolds with average porosity of 20–80 % were designed and fabricated by selective laser melting. Finite element modeling in the oral environment showed that the maximum von-Mises strains of cortical and cancellous bone around graded scaffolds with 20–50 % porosities were in the range of 100–3000 με and 1000–3000 με, respectively, which is beneficial for bone regeneration. Additionally, the graded scaffolds exhibited higher compressive yield strength (206.1–477.5 MPa) yet suitable elastic modulus (8.5–20.7 GPa) compared with human cortical bone. Permeability of graded scaffolds increased with increasing porosity that all fall in the range of the permeability for human bone. Corrosion rate of graded scaffolds with 20–40 % porosity satisfied the corrosion resistance for metallic implants (2.5 × 10−4/mm/yr). Moreover, the graded scaffolds with 20–40 % porosity exhibited 0-I grade toxic effects on mouse embryonic osteoblast precursor cell proliferation in vitro. Taken together, the graded scaffold with 30 % porosity meets all requirements as a promising dental implant. In addition, this study provided a rational approach for screening the best geometrical design of the implants in dentistry. |
| first_indexed | 2024-04-13T04:39:08Z |
| format | Article |
| id | doaj.art-d417e090eb994855bb7c6c183c046e43 |
| institution | Directory Open Access Journal |
| issn | 0264-1275 |
| language | English |
| last_indexed | 2024-04-13T04:39:08Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials & Design |
| spelling | doaj.art-d417e090eb994855bb7c6c183c046e432022-12-22T03:02:04ZengElsevierMaterials & Design0264-12752022-12-01224111300Gyroid-based functionally graded porous titanium scaffolds for dental application: Design, simulation and characterizationsWei Xu0Aihua Yu1Yu Jiang2Yageng Li3Ce Zhang4Harsh-preet Singh5Bowen Liu6Chenjin Hou7Yun Zhang8Shiwei Tian9Jiazhen Zhang10Xin Lu11Shunde Graduate School, University of Science and Technology Beijing, Foshan 528399, China; State Key Laboratory for Powder Metallurgy, Central South University, Changsha 410083, China; National Engineering Research Center for Advanced Rolling and Intelligent Manufacturing, Institute of Engineering Technology, University of Science and Technology Beijing, Beijing 100083, ChinaShunde Graduate School, University of Science and Technology Beijing, Foshan 528399, China; National Engineering Research Center for Advanced Rolling and Intelligent Manufacturing, Institute of Engineering Technology, University of Science and Technology Beijing, Beijing 100083, ChinaPeking University Third Hospital, Department of Orthopaedics, Engineering Research Center of Bone and Joint Precision Medicine, Beijing Key Laboratory of Spinal Disease Research, Beijing 100191, ChinaShunde Graduate School, University of Science and Technology Beijing, Foshan 528399, China; Beijing Advanced Innovation Center for Materials Genome Engineering, School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing 100083, China; Corresponding authors at: Shunde Graduate School, University of Science and Technology Beijing, Foshan 528399, China.Shunde Graduate School, University of Science and Technology Beijing, Foshan 528399, China; National Engineering Research Center for Advanced Rolling and Intelligent Manufacturing, Institute of Engineering Technology, University of Science and Technology Beijing, Beijing 100083, ChinaDepartment of Chemical and Materials Engineering, University of Auckland, Auckland 1142, New ZealandShunde Graduate School, University of Science and Technology Beijing, Foshan 528399, China; National Engineering Research Center for Advanced Rolling and Intelligent Manufacturing, Institute of Engineering Technology, University of Science and Technology Beijing, Beijing 100083, ChinaShunde Graduate School, University of Science and Technology Beijing, Foshan 528399, China; National Engineering Research Center for Advanced Rolling and Intelligent Manufacturing, Institute of Engineering Technology, University of Science and Technology Beijing, Beijing 100083, ChinaNational Engineering Research Center for Advanced Rolling and Intelligent Manufacturing, Institute of Engineering Technology, University of Science and Technology Beijing, Beijing 100083, ChinaNational Engineering Research Center for Advanced Rolling and Intelligent Manufacturing, Institute of Engineering Technology, University of Science and Technology Beijing, Beijing 100083, ChinaNational Engineering Research Center for Advanced Rolling and Intelligent Manufacturing, Institute of Engineering Technology, University of Science and Technology Beijing, Beijing 100083, ChinaShunde Graduate School, University of Science and Technology Beijing, Foshan 528399, China; National Engineering Research Center for Advanced Rolling and Intelligent Manufacturing, Institute of Engineering Technology, University of Science and Technology Beijing, Beijing 100083, China; Corresponding authors at: Shunde Graduate School, University of Science and Technology Beijing, Foshan 528399, China.To improve the mechanical compatibility and biocompatibility of porous scaffolds for dental application, functionally graded porous titanium scaffolds with average porosity of 20–80 % were designed and fabricated by selective laser melting. Finite element modeling in the oral environment showed that the maximum von-Mises strains of cortical and cancellous bone around graded scaffolds with 20–50 % porosities were in the range of 100–3000 με and 1000–3000 με, respectively, which is beneficial for bone regeneration. Additionally, the graded scaffolds exhibited higher compressive yield strength (206.1–477.5 MPa) yet suitable elastic modulus (8.5–20.7 GPa) compared with human cortical bone. Permeability of graded scaffolds increased with increasing porosity that all fall in the range of the permeability for human bone. Corrosion rate of graded scaffolds with 20–40 % porosity satisfied the corrosion resistance for metallic implants (2.5 × 10−4/mm/yr). Moreover, the graded scaffolds with 20–40 % porosity exhibited 0-I grade toxic effects on mouse embryonic osteoblast precursor cell proliferation in vitro. Taken together, the graded scaffold with 30 % porosity meets all requirements as a promising dental implant. In addition, this study provided a rational approach for screening the best geometrical design of the implants in dentistry.http://www.sciencedirect.com/science/article/pii/S0264127522009224Graded titanium scaffoldFinite element analysisSelective laser meltingBiocompatibilityDental applications |
| spellingShingle | Wei Xu Aihua Yu Yu Jiang Yageng Li Ce Zhang Harsh-preet Singh Bowen Liu Chenjin Hou Yun Zhang Shiwei Tian Jiazhen Zhang Xin Lu Gyroid-based functionally graded porous titanium scaffolds for dental application: Design, simulation and characterizations Materials & Design Graded titanium scaffold Finite element analysis Selective laser melting Biocompatibility Dental applications |
| title | Gyroid-based functionally graded porous titanium scaffolds for dental application: Design, simulation and characterizations |
| title_full | Gyroid-based functionally graded porous titanium scaffolds for dental application: Design, simulation and characterizations |
| title_fullStr | Gyroid-based functionally graded porous titanium scaffolds for dental application: Design, simulation and characterizations |
| title_full_unstemmed | Gyroid-based functionally graded porous titanium scaffolds for dental application: Design, simulation and characterizations |
| title_short | Gyroid-based functionally graded porous titanium scaffolds for dental application: Design, simulation and characterizations |
| title_sort | gyroid based functionally graded porous titanium scaffolds for dental application design simulation and characterizations |
| topic | Graded titanium scaffold Finite element analysis Selective laser melting Biocompatibility Dental applications |
| url | http://www.sciencedirect.com/science/article/pii/S0264127522009224 |
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