The potential of epigallocatechin gallate in the chemoprevention and therapy of hepatocellular carcinoma
Hepatocellular carcinoma (HCC), one of the most notorious malignancies globally, has a high fatality and poor prognosis. Though remarkable breakthroughs have been made in the therapeutic strategies recently, the overall survival of HCC remains unsatisfactory. Consequently, the therapy of HCC remains...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-05-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2023.1201085/full |
| _version_ | 1797821525087223808 |
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| author | Dongming Li Donghui Cao Yingnan Cui Yuanlin Sun Jing Jiang Xueyuan Cao |
| author_facet | Dongming Li Donghui Cao Yingnan Cui Yuanlin Sun Jing Jiang Xueyuan Cao |
| author_sort | Dongming Li |
| collection | DOAJ |
| description | Hepatocellular carcinoma (HCC), one of the most notorious malignancies globally, has a high fatality and poor prognosis. Though remarkable breakthroughs have been made in the therapeutic strategies recently, the overall survival of HCC remains unsatisfactory. Consequently, the therapy of HCC remains a great challenge. Epigallocatechin gallate (EGCG), a natural polyphenol extracted from the leaves of the tea bush, has been extensively investigated for its antitumor effects. In this review, we summarize the previous literature to elucidate the roles of EGCG in the chemoprophylaxis and therapy of HCC. Accumulating evidence has confirmed EGCG prevents and inhibits the hepatic tumorigenesis and progression through multiple biological mechanisms, mainly involving hepatitis virus infection, oxidative stress, proliferation, invasion, migration, angiogenesis, apoptosis, autophagy, and tumor metabolism. Furthermore, EGCG enhances the efficacy and sensitivity of chemotherapy, radiotherapy, and targeted therapy in HCC. In conclusion, preclinical studies have confirmed the potential of EGCG for chemoprevention and therapy of HCC under multifarious experimental models and conditions. Nevertheless, there is an urgent need to explore the safety and efficacy of EGCG in the clinical practice of HCC. |
| first_indexed | 2024-03-13T09:54:01Z |
| format | Article |
| id | doaj.art-d41998ef939f4c0094b7bd159129f276 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-03-13T09:54:01Z |
| publishDate | 2023-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-d41998ef939f4c0094b7bd159129f2762023-05-24T04:26:23ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122023-05-011410.3389/fphar.2023.12010851201085The potential of epigallocatechin gallate in the chemoprevention and therapy of hepatocellular carcinomaDongming Li0Donghui Cao1Yingnan Cui2Yuanlin Sun3Jing Jiang4Xueyuan Cao5Department of Gastric and Colorectal Surgery, General Surgery Center, The First Hospital of Jilin University, Changchun, Jilin, ChinaDivision of Clinical Epidemiology, The First Hospital of Jilin University, Changchun, ChinaDepartment of Gastric and Colorectal Surgery, General Surgery Center, The First Hospital of Jilin University, Changchun, Jilin, ChinaDepartment of Gastric and Colorectal Surgery, General Surgery Center, The First Hospital of Jilin University, Changchun, Jilin, ChinaDivision of Clinical Epidemiology, The First Hospital of Jilin University, Changchun, ChinaDepartment of Gastric and Colorectal Surgery, General Surgery Center, The First Hospital of Jilin University, Changchun, Jilin, ChinaHepatocellular carcinoma (HCC), one of the most notorious malignancies globally, has a high fatality and poor prognosis. Though remarkable breakthroughs have been made in the therapeutic strategies recently, the overall survival of HCC remains unsatisfactory. Consequently, the therapy of HCC remains a great challenge. Epigallocatechin gallate (EGCG), a natural polyphenol extracted from the leaves of the tea bush, has been extensively investigated for its antitumor effects. In this review, we summarize the previous literature to elucidate the roles of EGCG in the chemoprophylaxis and therapy of HCC. Accumulating evidence has confirmed EGCG prevents and inhibits the hepatic tumorigenesis and progression through multiple biological mechanisms, mainly involving hepatitis virus infection, oxidative stress, proliferation, invasion, migration, angiogenesis, apoptosis, autophagy, and tumor metabolism. Furthermore, EGCG enhances the efficacy and sensitivity of chemotherapy, radiotherapy, and targeted therapy in HCC. In conclusion, preclinical studies have confirmed the potential of EGCG for chemoprevention and therapy of HCC under multifarious experimental models and conditions. Nevertheless, there is an urgent need to explore the safety and efficacy of EGCG in the clinical practice of HCC.https://www.frontiersin.org/articles/10.3389/fphar.2023.1201085/fullepigallocatechin gallatehepatocellular carcinomacancer preventioncancer therapyanticancer |
| spellingShingle | Dongming Li Donghui Cao Yingnan Cui Yuanlin Sun Jing Jiang Xueyuan Cao The potential of epigallocatechin gallate in the chemoprevention and therapy of hepatocellular carcinoma Frontiers in Pharmacology epigallocatechin gallate hepatocellular carcinoma cancer prevention cancer therapy anticancer |
| title | The potential of epigallocatechin gallate in the chemoprevention and therapy of hepatocellular carcinoma |
| title_full | The potential of epigallocatechin gallate in the chemoprevention and therapy of hepatocellular carcinoma |
| title_fullStr | The potential of epigallocatechin gallate in the chemoprevention and therapy of hepatocellular carcinoma |
| title_full_unstemmed | The potential of epigallocatechin gallate in the chemoprevention and therapy of hepatocellular carcinoma |
| title_short | The potential of epigallocatechin gallate in the chemoprevention and therapy of hepatocellular carcinoma |
| title_sort | potential of epigallocatechin gallate in the chemoprevention and therapy of hepatocellular carcinoma |
| topic | epigallocatechin gallate hepatocellular carcinoma cancer prevention cancer therapy anticancer |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2023.1201085/full |
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