Early-stage mapping of macromolecular content in APPNL-F mouse model of Alzheimer’s disease using nuclear Overhauser effect MRI
Non-invasive methods of detecting early-stage Alzheimer’s disease (AD) can provide valuable insight into disease pathology, improving the diagnosis and treatment of AD. Nuclear Overhauser enhancement (NOE) MRI is a technique that provides image contrast sensitive to lipid and protein content in the...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-10-01
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| Series: | Frontiers in Aging Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2023.1266859/full |
| _version_ | 1797663369171304448 |
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| author | Anshuman Swain Anshuman Swain Narayan D. Soni Neil Wilson Halvor Juul Halvor Juul Blake Benyard Blake Benyard Mohammad Haris Dushyant Kumar Ravi Prakash Reddy Nanga John Detre John Detre Virginia M. Lee Virginia M. Lee Ravinder Reddy |
| author_facet | Anshuman Swain Anshuman Swain Narayan D. Soni Neil Wilson Halvor Juul Halvor Juul Blake Benyard Blake Benyard Mohammad Haris Dushyant Kumar Ravi Prakash Reddy Nanga John Detre John Detre Virginia M. Lee Virginia M. Lee Ravinder Reddy |
| author_sort | Anshuman Swain |
| collection | DOAJ |
| description | Non-invasive methods of detecting early-stage Alzheimer’s disease (AD) can provide valuable insight into disease pathology, improving the diagnosis and treatment of AD. Nuclear Overhauser enhancement (NOE) MRI is a technique that provides image contrast sensitive to lipid and protein content in the brain. These macromolecules have been shown to be altered in Alzheimer’s pathology, with early disruptions in cell membrane integrity and signaling pathways leading to the buildup of amyloid-beta plaques and neurofibrillary tangles. We used template-based analyzes of NOE MRI data and the characteristic Z-spectrum, with parameters optimized for increase specificity to NOE, to detect changes in lipids and proteins in an AD mouse model that recapitulates features of human AD. We find changes in NOE contrast in the hippocampus, hypothalamus, entorhinal cortex, and fimbria, with these changes likely attributed to disruptions in the phospholipid bilayer of cell membranes in both gray and white matter regions. This study suggests that NOE MRI may be a useful tool for monitoring early-stage changes in lipid-mediated metabolism in AD and other disorders with high spatial resolution. |
| first_indexed | 2024-03-11T19:13:30Z |
| format | Article |
| id | doaj.art-d41a61930dde46918e72774afb15562a |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-03-11T19:13:30Z |
| publishDate | 2023-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-d41a61930dde46918e72774afb15562a2023-10-09T10:13:02ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652023-10-011510.3389/fnagi.2023.12668591266859Early-stage mapping of macromolecular content in APPNL-F mouse model of Alzheimer’s disease using nuclear Overhauser effect MRIAnshuman Swain0Anshuman Swain1Narayan D. Soni2Neil Wilson3Halvor Juul4Halvor Juul5Blake Benyard6Blake Benyard7Mohammad Haris8Dushyant Kumar9Ravi Prakash Reddy Nanga10John Detre11John Detre12Virginia M. Lee13Virginia M. Lee14Ravinder Reddy15School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA, United StatesCenter for Advanced Metabolic Imaging in Precision Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United StatesCenter for Advanced Metabolic Imaging in Precision Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United StatesCenter for Advanced Metabolic Imaging in Precision Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United StatesCenter for Advanced Metabolic Imaging in Precision Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United StatesDepartment of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United StatesSchool of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA, United StatesCenter for Advanced Metabolic Imaging in Precision Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United StatesCenter for Advanced Metabolic Imaging in Precision Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United StatesCenter for Advanced Metabolic Imaging in Precision Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United StatesCenter for Advanced Metabolic Imaging in Precision Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United StatesCenter for Functional Neuroimaging, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United StatesDepartment of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United StatesCenter for Neurodegenerative Disease Research, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United StatesAlzheimer’s Disease Research Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United StatesCenter for Advanced Metabolic Imaging in Precision Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United StatesNon-invasive methods of detecting early-stage Alzheimer’s disease (AD) can provide valuable insight into disease pathology, improving the diagnosis and treatment of AD. Nuclear Overhauser enhancement (NOE) MRI is a technique that provides image contrast sensitive to lipid and protein content in the brain. These macromolecules have been shown to be altered in Alzheimer’s pathology, with early disruptions in cell membrane integrity and signaling pathways leading to the buildup of amyloid-beta plaques and neurofibrillary tangles. We used template-based analyzes of NOE MRI data and the characteristic Z-spectrum, with parameters optimized for increase specificity to NOE, to detect changes in lipids and proteins in an AD mouse model that recapitulates features of human AD. We find changes in NOE contrast in the hippocampus, hypothalamus, entorhinal cortex, and fimbria, with these changes likely attributed to disruptions in the phospholipid bilayer of cell membranes in both gray and white matter regions. This study suggests that NOE MRI may be a useful tool for monitoring early-stage changes in lipid-mediated metabolism in AD and other disorders with high spatial resolution.https://www.frontiersin.org/articles/10.3389/fnagi.2023.1266859/fullNOEAlzheimer’s diseasemultipool fittinglipid dyshomeostasisCEST |
| spellingShingle | Anshuman Swain Anshuman Swain Narayan D. Soni Neil Wilson Halvor Juul Halvor Juul Blake Benyard Blake Benyard Mohammad Haris Dushyant Kumar Ravi Prakash Reddy Nanga John Detre John Detre Virginia M. Lee Virginia M. Lee Ravinder Reddy Early-stage mapping of macromolecular content in APPNL-F mouse model of Alzheimer’s disease using nuclear Overhauser effect MRI Frontiers in Aging Neuroscience NOE Alzheimer’s disease multipool fitting lipid dyshomeostasis CEST |
| title | Early-stage mapping of macromolecular content in APPNL-F mouse model of Alzheimer’s disease using nuclear Overhauser effect MRI |
| title_full | Early-stage mapping of macromolecular content in APPNL-F mouse model of Alzheimer’s disease using nuclear Overhauser effect MRI |
| title_fullStr | Early-stage mapping of macromolecular content in APPNL-F mouse model of Alzheimer’s disease using nuclear Overhauser effect MRI |
| title_full_unstemmed | Early-stage mapping of macromolecular content in APPNL-F mouse model of Alzheimer’s disease using nuclear Overhauser effect MRI |
| title_short | Early-stage mapping of macromolecular content in APPNL-F mouse model of Alzheimer’s disease using nuclear Overhauser effect MRI |
| title_sort | early stage mapping of macromolecular content in appnl f mouse model of alzheimer s disease using nuclear overhauser effect mri |
| topic | NOE Alzheimer’s disease multipool fitting lipid dyshomeostasis CEST |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2023.1266859/full |
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