Early-stage mapping of macromolecular content in APPNL-F mouse model of Alzheimer’s disease using nuclear Overhauser effect MRI

Early-stage mapping of macromolecular content in APPNL-F mouse model of Alzheimer’s disease using nuclear Overhauser effect MRI

Non-invasive methods of detecting early-stage Alzheimer’s disease (AD) can provide valuable insight into disease pathology, improving the diagnosis and treatment of AD. Nuclear Overhauser enhancement (NOE) MRI is a technique that provides image contrast sensitive to lipid and protein content in the...

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Bibliographic Details
Main Authors: Anshuman Swain, Narayan D. Soni, Neil Wilson, Halvor Juul, Blake Benyard, Mohammad Haris, Dushyant Kumar, Ravi Prakash Reddy Nanga, John Detre, Virginia M. Lee, Ravinder Reddy
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Aging Neuroscience
Subjects:
NOE
Alzheimer’s disease
multipool fitting
lipid dyshomeostasis
CEST
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2023.1266859/full

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