The Effect of Dexmedetomidine on the Mini-Cog Score and High-Mobility Group Box 1 Levels in Elderly Patients with Postoperative Neurocognitive Disorders Undergoing Orthopedic Surgery

The Effect of Dexmedetomidine on the Mini-Cog Score and High-Mobility Group Box 1 Levels in Elderly Patients with Postoperative Neurocognitive Disorders Undergoing Orthopedic Surgery

Dexmedetomidine prevents postoperative cognitive dysfunction by inhibiting high-mobility group box 1 (HMGB1), which acts as an inflammatory marker. This study investigated the HMGB1 levels and the cognitive function using a Mini-Cog© score in elderly patients undergoing orthopedic surgery with dexme...

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Bibliographic Details
Main Authors: Seung Hee Yoo, Mi Jin Jue, Yu-Hee Kim, Sooyoung Cho, Won-joong Kim, Kye-Min Kim, Jong In Han, Heeseung Lee
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Journal of Clinical Medicine
Subjects:
aged
dexmedetomidine
HMGB1
Mini-Cog
neurocognitive disorders
orthopedic surgery
Online Access:https://www.mdpi.com/2077-0383/12/20/6610

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