Intracranial metastasis of testicular germ cell tumours
Brain metastasis from testicular germ cell tumour (TGCT) is rare and represents only 2% of metastatic brain tumours. Although TGCTs have a good survival rate, the prognosis of brain metastasis is poor. Due to the rarity of the diagnosis, there are limited studies on the topic and a standardized tre...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Pakistan Medical Association
2023-04-01
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| Series: | Journal of the Pakistan Medical Association |
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| Online Access: | https://www.ojs.jpma.org.pk/index.php/public_html/article/view/9897 |
| _version_ | 1797821043149111296 |
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| author | Zara Shah Hafiza Hifza Bashir Saqib Kamran Bakhshi Muhammad Shahzad Shamim |
| author_facet | Zara Shah Hafiza Hifza Bashir Saqib Kamran Bakhshi Muhammad Shahzad Shamim |
| author_sort | Zara Shah |
| collection | DOAJ |
| description |
Brain metastasis from testicular germ cell tumour (TGCT) is rare and represents only 2% of metastatic brain tumours. Although TGCTs have a good survival rate, the prognosis of brain metastasis is poor. Due to the rarity of the diagnosis, there are limited studies on the topic and a standardized treatment protocol does not exist. Surgical management has long been considered a positive prognostic factor; however, recent studies have investigated the impact of chemotherapy and radiotherapy in these patients. Current literature suggests multiplicity of brain lesions and treatment with chemotherapy or radiotherapy alone can have a poor impact on the prognosis of the disease. However, studies with larger cohorts are required to understand and develop the optimal treatment protocol for patients with brain metastasis from TGCT.
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| first_indexed | 2024-03-13T09:46:56Z |
| format | Article |
| id | doaj.art-d41e5001d2474e428043ac01251b3ce0 |
| institution | Directory Open Access Journal |
| issn | 0030-9982 |
| language | English |
| last_indexed | 2024-03-13T09:46:56Z |
| publishDate | 2023-04-01 |
| publisher | Pakistan Medical Association |
| record_format | Article |
| series | Journal of the Pakistan Medical Association |
| spelling | doaj.art-d41e5001d2474e428043ac01251b3ce02023-05-25T04:20:11ZengPakistan Medical AssociationJournal of the Pakistan Medical Association0030-99822023-04-01730510.47391/JPMA.23-37Intracranial metastasis of testicular germ cell tumoursZara Shah0Hafiza Hifza Bashir1Saqib Kamran Bakhshi2Muhammad Shahzad Shamim3Section of Neurosurgery, Department of Surgery, Aga Khan University, Karachi, Pakistan Liaquat National Hospital and Medical College, Karachi, Pakistan Section of Neurosurgery, Department of Surgery, Aga Khan University Hospital, Karachi, PakistanSection of Neurosurgery, Department of Surgery, Aga Khan University Hospital, Karachi Brain metastasis from testicular germ cell tumour (TGCT) is rare and represents only 2% of metastatic brain tumours. Although TGCTs have a good survival rate, the prognosis of brain metastasis is poor. Due to the rarity of the diagnosis, there are limited studies on the topic and a standardized treatment protocol does not exist. Surgical management has long been considered a positive prognostic factor; however, recent studies have investigated the impact of chemotherapy and radiotherapy in these patients. Current literature suggests multiplicity of brain lesions and treatment with chemotherapy or radiotherapy alone can have a poor impact on the prognosis of the disease. However, studies with larger cohorts are required to understand and develop the optimal treatment protocol for patients with brain metastasis from TGCT. https://www.ojs.jpma.org.pk/index.php/public_html/article/view/9897Intracranial metastasis of testicular germ cell tumours |
| spellingShingle | Zara Shah Hafiza Hifza Bashir Saqib Kamran Bakhshi Muhammad Shahzad Shamim Intracranial metastasis of testicular germ cell tumours Journal of the Pakistan Medical Association Intracranial metastasis of testicular germ cell tumours |
| title | Intracranial metastasis of testicular germ cell tumours |
| title_full | Intracranial metastasis of testicular germ cell tumours |
| title_fullStr | Intracranial metastasis of testicular germ cell tumours |
| title_full_unstemmed | Intracranial metastasis of testicular germ cell tumours |
| title_short | Intracranial metastasis of testicular germ cell tumours |
| title_sort | intracranial metastasis of testicular germ cell tumours |
| topic | Intracranial metastasis of testicular germ cell tumours |
| url | https://www.ojs.jpma.org.pk/index.php/public_html/article/view/9897 |
| work_keys_str_mv | AT zarashah intracranialmetastasisoftesticulargermcelltumours AT hafizahifzabashir intracranialmetastasisoftesticulargermcelltumours AT saqibkamranbakhshi intracranialmetastasisoftesticulargermcelltumours AT muhammadshahzadshamim intracranialmetastasisoftesticulargermcelltumours |