Association of Human Leukocyte AntigenCw6 in Psoriasis Patients with Disease Severity and Morphological Patterns: A Cross-control Study in a Tertiary Care Referral Centre in Eastern India
Introduction: Psoriasis is a multifactorial disorder in which genetic and environmental factors play an essential role in disease pathogenesis. The Human Leukocyte Antigen-Cw6 (HLA-Cw6) allele has shown the strongest genetic association with this condition across several populations studied. Ai...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2021-08-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/15198/50595_CE[Ra1]_F[SK]_PF1(AG_OM)_PFA(KM)_PB(AG_KM)_PN(KM).pdf |
| Summary: | Introduction: Psoriasis is a multifactorial disorder in which
genetic and environmental factors play an essential role in
disease pathogenesis. The Human Leukocyte Antigen-Cw6
(HLA-Cw6) allele has shown the strongest genetic association
with this condition across several populations studied.
Aim: To estimate the risk of HLA-Cw6 association with psoriasis
compared to the control group and its association with the
severity of psoriasis expressed as Psoriasis Area and Severity
Index (PASI) score and morphological patterns.
Materials and Methods: A cross-control study was conducted
from March 2014 to February 2015 in a tertiary care centre
in the eastern part of India. All patients who were diagnosed
clinically as psoriasis and gave written informed consent were
included in the study. Healthy controls were taken to compare
the HLA-Cw6 after duly signing the informed consent for
detailed history, clinical examination, PASI score, and digital
photographs of lesions were taken. A blood sample was taken
from patients and the control for HLA-Cw6 typing by sequencespecific Polymerase Chain Reaction (PCR) method. Data was
analysed by appropriate statistical test (Chi-square test) using
R statistical software.
Results: A total of 100 patients with psoriasis and 100 controls
were recruited, of which 61 were positive for HLA-Cw6 among
the psoriasis group and nine in the control group. Positivity of
the HLA-Cw6 allele was significantly higher in psoriasis cases
(n=61) compared to normal individuals (n=9) (p-value: 1.79×10-15,
OR: 15.8148, 95% CI: 7.15-34.99). It was also observed that
HLA-Cw6 positive individuals had a more severe form of the
disease, determined by a PASI score >6 (p-value: 0.0494, OR:
2.22, 95% CI: 0.96-5.15), and significant involvement of scalp
psoriasis (p-value: 0.0054, OR: 13.125, 95% CI: 1.55-111.42).
However, no significant association of HLA-Cw6 was seen with
positive family history, nail involvement, and joint pain (arthralgia).
Conclusion: The HLA-Cw6 positivity was associated with a
more severe form of disease and scalp psoriasis. |
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| ISSN: | 2249-782X 0973-709X |