Noncanonical functions of microRNAs in the nucleus
MicroRNAs (miRNAs) are small noncoding RNAs (ncRNAs) that play their roles in the regulation of physiological and pathological processes. Originally, it was assumed that miRNAs only modulate gene expression posttranscriptionally in the cyto...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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China Science Publishing & Media Ltd.
2024-01-01
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| Series: | Acta Biochimica et Biophysica Sinica |
| Subjects: | |
| Online Access: | https://www.sciengine.com/doi/10.3724/abbs.2023268 |
| _version_ | 1797294033219878912 |
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| author | Gu Jiayi Li Yuanan Tian Youtong Zhang Yehao Cheng Yongjun Tang Yuanjia |
| author_facet | Gu Jiayi Li Yuanan Tian Youtong Zhang Yehao Cheng Yongjun Tang Yuanjia |
| author_sort | Gu Jiayi |
| collection | DOAJ |
| description | MicroRNAs (miRNAs) are small noncoding RNAs (ncRNAs) that play their roles in the regulation of physiological and pathological processes. Originally, it was assumed that miRNAs only modulate gene expression posttranscriptionally in the cytoplasm by inducing target mRNA degradation. However, with further research, evidence shows that mature miRNAs also exist in the cell nucleus, where they can impact gene transcription and ncRNA maturation in several ways. This review provides an overview of novel models of nuclear miRNA functions. Some of the models remain to be verified by experimental evidence, and more details of the miRNA regulation network remain to be discovered in the future. |
| first_indexed | 2024-03-07T21:24:18Z |
| format | Article |
| id | doaj.art-d41f1a26e7ef479b95c914c618480477 |
| institution | Directory Open Access Journal |
| issn | 1672-9145 |
| language | English |
| last_indexed | 2024-03-07T21:24:18Z |
| publishDate | 2024-01-01 |
| publisher | China Science Publishing & Media Ltd. |
| record_format | Article |
| series | Acta Biochimica et Biophysica Sinica |
| spelling | doaj.art-d41f1a26e7ef479b95c914c6184804772024-02-27T07:34:45ZengChina Science Publishing & Media Ltd.Acta Biochimica et Biophysica Sinica1672-91452024-01-015615116110.3724/abbs.202326820d259ccNoncanonical functions of microRNAs in the nucleusGu Jiayi0Li Yuanan1Tian Youtong2Zhang Yehao3Cheng Yongjun4Tang Yuanjia5["College of Basic Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai 200001, China"]["College of Basic Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai 200001, China"]["College of Basic Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai 200001, China"]["College of Basic Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai 200001, China"]["Department of Rheumatology, the First People’s Hospital of Wenling, Wenling 317500, China"]["Shanghai Institute of Rheumatology/Department of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200001, China","State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai 200031, China"]MicroRNAs (miRNAs) are small noncoding RNAs (ncRNAs) that play their roles in the regulation of physiological and pathological processes. Originally, it was assumed that miRNAs only modulate gene expression posttranscriptionally in the cytoplasm by inducing target mRNA degradation. However, with further research, evidence shows that mature miRNAs also exist in the cell nucleus, where they can impact gene transcription and ncRNA maturation in several ways. This review provides an overview of novel models of nuclear miRNA functions. Some of the models remain to be verified by experimental evidence, and more details of the miRNA regulation network remain to be discovered in the future.https://www.sciengine.com/doi/10.3724/abbs.2023268microRNAnuclear localizationmiRNA-inducing silencing complex (miRISC)gene regulationtranscriptional control |
| spellingShingle | Gu Jiayi Li Yuanan Tian Youtong Zhang Yehao Cheng Yongjun Tang Yuanjia Noncanonical functions of microRNAs in the nucleus Acta Biochimica et Biophysica Sinica microRNA nuclear localization miRNA-inducing silencing complex (miRISC) gene regulation transcriptional control |
| title | Noncanonical functions of microRNAs in the nucleus |
| title_full | Noncanonical functions of microRNAs in the nucleus |
| title_fullStr | Noncanonical functions of microRNAs in the nucleus |
| title_full_unstemmed | Noncanonical functions of microRNAs in the nucleus |
| title_short | Noncanonical functions of microRNAs in the nucleus |
| title_sort | noncanonical functions of micrornas in the nucleus |
| topic | microRNA nuclear localization miRNA-inducing silencing complex (miRISC) gene regulation transcriptional control |
| url | https://www.sciengine.com/doi/10.3724/abbs.2023268 |
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