Korea-nationwide incidence of pediatric deceased donors and single-institutional status of liver transplantation using pediatric donor liver grafts
Background : The present study intended to investigate the allocation status of pediatric deceased donor liver allografts. We analyzed the incidence of pediatric deceased donors in the Korean Network for Organ Sharing (KONOS) database and single-institutional status of liver transplantation (LT) usi...
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| Format: | Article |
| Language: | English |
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Korean Society for Transplantation
2020-09-01
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| Series: | Korean Journal of Transplantation |
| Subjects: | |
| Online Access: | http://journaleditor.inforang.com/journal/view.html?doi=10.4285/kjt.2020.34.3.178 |
| _version_ | 1797334891761762304 |
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| author | Jung-Man Namgung Shin Hwang Chul-Soo Ahn Ki-Hun Kim Deok-Bog Moon Tae-Yong Ha Gi-Won Song Dong-Hwan Jung Gil-Chun Park Dea-Yeon Kim Kyung Mo Kim Seak Hee Oh Sung-Gyu Lee |
| author_facet | Jung-Man Namgung Shin Hwang Chul-Soo Ahn Ki-Hun Kim Deok-Bog Moon Tae-Yong Ha Gi-Won Song Dong-Hwan Jung Gil-Chun Park Dea-Yeon Kim Kyung Mo Kim Seak Hee Oh Sung-Gyu Lee |
| author_sort | Jung-Man Namgung |
| collection | DOAJ |
| description | Background : The present study intended to investigate the allocation status of pediatric deceased donor liver allografts. We analyzed the incidence of pediatric deceased donors in the Korean Network for Organ Sharing (KONOS) database and single-institutional status of liver transplantation (LT) using pediatric donors.
Methods : We assessed the nationwide incidence of pediatric donors aged ≤15 years and conducted single-center analysis of LT using pediatric donors.
Results : Between 2010 and 2019, pediatric donors aged ≤15 years accounted for 171 out of 4,395 donors (3.9%) in the KONOS database and 31 out of 640 liver donors (4.8%) in Asan Medical Center (AMC) database. In AMC, 11 (35.5%) and 20 (64.5%) grafts were allocated to pediatric recipients aged ≤15 years and adult recipients aged ≥19 years, respectively. All nine livers from donors aged ≤5 years were implanted in pediatric recipients aged ≤5 years. From 21 donors aged ≥9 years, 16 whole liver grafts and four split extended right liver grafts were implanted in 20 adult recipients and two split left lateral section grafts were implanted in two pediatric recipients. Four split liver grafts were implanted in other institutions. The overall patient survival rates at 1, 3, and 5 years were 90.9%, 80.8%, and 80.8%, respectively in pediatric-to-pediatric LT group and 69.6%, 58.4%, and 58.4%, respectively in pediatric-to-adult LT group (P=0.21).
Conclusions: More than half of the pediatric donor livers were allocated to adult patients. Recipient criteria for allocation of liver allografts from pediatric donors need revision for children on pediatric LT waitlist. |
| first_indexed | 2024-03-08T08:27:47Z |
| format | Article |
| id | doaj.art-d421079ed66840f283506cd9da2f83ab |
| institution | Directory Open Access Journal |
| issn | 2671-8790 |
| language | English |
| last_indexed | 2024-03-08T08:27:47Z |
| publishDate | 2020-09-01 |
| publisher | Korean Society for Transplantation |
| record_format | Article |
| series | Korean Journal of Transplantation |
| spelling | doaj.art-d421079ed66840f283506cd9da2f83ab2024-02-02T04:20:13ZengKorean Society for TransplantationKorean Journal of Transplantation2671-87902020-09-0134317818410.4285/kjt.2020.34.3.178kjt.2020.34.3.178Korea-nationwide incidence of pediatric deceased donors and single-institutional status of liver transplantation using pediatric donor liver graftsJung-Man Namgung0Shin Hwang1Chul-Soo Ahn2Ki-Hun Kim3Deok-Bog Moon4Tae-Yong Ha5Gi-Won Song6Dong-Hwan Jung7Gil-Chun Park8Dea-Yeon Kim9Kyung Mo Kim10Seak Hee Oh11Sung-Gyu Lee12Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, KoreaDepartment of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, KoreaDepartment of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, KoreaDepartment of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, KoreaDepartment of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, KoreaDepartment of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, KoreaDepartment of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, KoreaDepartment of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, KoreaDepartment of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, KoreaDepartment of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, KoreaDepartment of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, KoreaDepartment of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, KoreaDepartment of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, KoreaBackground : The present study intended to investigate the allocation status of pediatric deceased donor liver allografts. We analyzed the incidence of pediatric deceased donors in the Korean Network for Organ Sharing (KONOS) database and single-institutional status of liver transplantation (LT) using pediatric donors. Methods : We assessed the nationwide incidence of pediatric donors aged ≤15 years and conducted single-center analysis of LT using pediatric donors. Results : Between 2010 and 2019, pediatric donors aged ≤15 years accounted for 171 out of 4,395 donors (3.9%) in the KONOS database and 31 out of 640 liver donors (4.8%) in Asan Medical Center (AMC) database. In AMC, 11 (35.5%) and 20 (64.5%) grafts were allocated to pediatric recipients aged ≤15 years and adult recipients aged ≥19 years, respectively. All nine livers from donors aged ≤5 years were implanted in pediatric recipients aged ≤5 years. From 21 donors aged ≥9 years, 16 whole liver grafts and four split extended right liver grafts were implanted in 20 adult recipients and two split left lateral section grafts were implanted in two pediatric recipients. Four split liver grafts were implanted in other institutions. The overall patient survival rates at 1, 3, and 5 years were 90.9%, 80.8%, and 80.8%, respectively in pediatric-to-pediatric LT group and 69.6%, 58.4%, and 58.4%, respectively in pediatric-to-adult LT group (P=0.21). Conclusions: More than half of the pediatric donor livers were allocated to adult patients. Recipient criteria for allocation of liver allografts from pediatric donors need revision for children on pediatric LT waitlist.http://journaleditor.inforang.com/journal/view.html?doi=10.4285/kjt.2020.34.3.178donor age; pediatric donor; deceased donor liver transplantation; infant; split liver transplantation |
| spellingShingle | Jung-Man Namgung Shin Hwang Chul-Soo Ahn Ki-Hun Kim Deok-Bog Moon Tae-Yong Ha Gi-Won Song Dong-Hwan Jung Gil-Chun Park Dea-Yeon Kim Kyung Mo Kim Seak Hee Oh Sung-Gyu Lee Korea-nationwide incidence of pediatric deceased donors and single-institutional status of liver transplantation using pediatric donor liver grafts Korean Journal of Transplantation donor age; pediatric donor; deceased donor liver transplantation; infant; split liver transplantation |
| title | Korea-nationwide incidence of pediatric deceased donors and single-institutional status of liver transplantation using pediatric donor liver grafts |
| title_full | Korea-nationwide incidence of pediatric deceased donors and single-institutional status of liver transplantation using pediatric donor liver grafts |
| title_fullStr | Korea-nationwide incidence of pediatric deceased donors and single-institutional status of liver transplantation using pediatric donor liver grafts |
| title_full_unstemmed | Korea-nationwide incidence of pediatric deceased donors and single-institutional status of liver transplantation using pediatric donor liver grafts |
| title_short | Korea-nationwide incidence of pediatric deceased donors and single-institutional status of liver transplantation using pediatric donor liver grafts |
| title_sort | korea nationwide incidence of pediatric deceased donors and single institutional status of liver transplantation using pediatric donor liver grafts |
| topic | donor age; pediatric donor; deceased donor liver transplantation; infant; split liver transplantation |
| url | http://journaleditor.inforang.com/journal/view.html?doi=10.4285/kjt.2020.34.3.178 |
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