Pin2 telomeric repeat factor 1-interacting telomerase inhibitor 1 (PinX1) inhibits nasopharyngeal cancer cell stemness: implication for cancer progression and therapeutic targeting

Pin2 telomeric repeat factor 1-interacting telomerase inhibitor 1 (PinX1) inhibits nasopharyngeal cancer cell stemness: implication for cancer progression and therapeutic targeting

Abstract Background Recurrence and distant metastasis are still the main factors leading to treatment failure for malignant tumors including nasopharyngeal carcinoma (NPC). Therefore, elucidating the molecular mechanisms underlying nasopharyngeal carcinoma metastasis is of great clinical significanc...

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Bibliographic Details
Main Authors: Chaosheng Yu, Fang Chen, Xiaoqi Wang, Zhimou Cai, Mengxue Yang, Qingwen Zhong, Jialian Feng, Junzheng Li, Congxiang Shen, Zhong Wen
Format: Article
Language:English
Published: BMC 2020-02-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
PinX1
Nasopharyngeal carcinoma
miR-200b
Migration
Invasion
Transcriptional regulation
Online Access:https://doi.org/10.1186/s13046-020-1530-3

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